Sodium tetraphenylborate (TPB) and cetylpyridinium bromide (CPB) were used as titrant for the conductometric determination of diphenhydramine hydrochloride (DPH) drug through ion association complex formation and then the conductance of the solution is measured as a function of the volume of titrant. The effect of the solvent, reagent concentration, temperature and molar combining ratio of the formed ion-associates were studied and evaluated. The suggested method was applied for the determination of diphenhydramine hydrochloride in pure form and pharmaceutical preparations. The described procedures allowed the determination of the studied drug in bi-distilled water in the range of 0.75–16 mg. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method was indicated by excellent recovery and the precision supported by the low relative standard deviation <1%. The sensitivity of the proposed method was discussed and the results were compared with the potentiometric pharmacopoeial method. The proposed procedure was simple, precise and low cost and can be applied for the routine measurements of the cited drug.
| Published in | International Journal of Pharmacy and Chemistry (Volume 4, Issue 1) |
| DOI | 10.11648/j.ijpc.20180401.12 |
| Page(s) | 8-15 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Diphenhydramine Hydrochloride, Sodium Tetraphenylborate, Cetylpyridinium Bromide, Conductometry, Pharmaceutical Formulations
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APA Style
Safwan Ashour, Haitham Aboudan. (2018). New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide. International Journal of Pharmacy and Chemistry, 4(1), 8-15. https://doi.org/10.11648/j.ijpc.20180401.12
ACS Style
Safwan Ashour; Haitham Aboudan. New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide. Int. J. Pharm. Chem. 2018, 4(1), 8-15. doi: 10.11648/j.ijpc.20180401.12
AMA Style
Safwan Ashour, Haitham Aboudan. New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide. Int J Pharm Chem. 2018;4(1):8-15. doi: 10.11648/j.ijpc.20180401.12
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Download@article{10.11648/j.ijpc.20180401.12,
author = {Safwan Ashour and Haitham Aboudan},
title = {New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide},
journal = {International Journal of Pharmacy and Chemistry},
volume = {4},
number = {1},
pages = {8-15},
doi = {10.11648/j.ijpc.20180401.12},
url = {https://doi.org/10.11648/j.ijpc.20180401.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20180401.12},
abstract = {Sodium tetraphenylborate (TPB) and cetylpyridinium bromide (CPB) were used as titrant for the conductometric determination of diphenhydramine hydrochloride (DPH) drug through ion association complex formation and then the conductance of the solution is measured as a function of the volume of titrant. The effect of the solvent, reagent concentration, temperature and molar combining ratio of the formed ion-associates were studied and evaluated. The suggested method was applied for the determination of diphenhydramine hydrochloride in pure form and pharmaceutical preparations. The described procedures allowed the determination of the studied drug in bi-distilled water in the range of 0.75–16 mg. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method was indicated by excellent recovery and the precision supported by the low relative standard deviation <1%. The sensitivity of the proposed method was discussed and the results were compared with the potentiometric pharmacopoeial method. The proposed procedure was simple, precise and low cost and can be applied for the routine measurements of the cited drug.},
year = {2018}
}
TY - JOUR T1 - New Conductometric Titration Methods for Determination of Diphenhydramine Hydrochloride Using Sodium Tetraphenylborate and Cetylpyridinium Bromide AU - Safwan Ashour AU - Haitham Aboudan Y1 - 2018/02/26 PY - 2018 N1 - https://doi.org/10.11648/j.ijpc.20180401.12 DO - 10.11648/j.ijpc.20180401.12 T2 - International Journal of Pharmacy and Chemistry JF - International Journal of Pharmacy and Chemistry JO - International Journal of Pharmacy and Chemistry SP - 8 EP - 15 PB - Science Publishing Group SN - 2575-5749 UR - https://doi.org/10.11648/j.ijpc.20180401.12 AB - Sodium tetraphenylborate (TPB) and cetylpyridinium bromide (CPB) were used as titrant for the conductometric determination of diphenhydramine hydrochloride (DPH) drug through ion association complex formation and then the conductance of the solution is measured as a function of the volume of titrant. The effect of the solvent, reagent concentration, temperature and molar combining ratio of the formed ion-associates were studied and evaluated. The suggested method was applied for the determination of diphenhydramine hydrochloride in pure form and pharmaceutical preparations. The described procedures allowed the determination of the studied drug in bi-distilled water in the range of 0.75–16 mg. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method was indicated by excellent recovery and the precision supported by the low relative standard deviation <1%. The sensitivity of the proposed method was discussed and the results were compared with the potentiometric pharmacopoeial method. The proposed procedure was simple, precise and low cost and can be applied for the routine measurements of the cited drug. VL - 4 IS - 1 ER -
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