Status of Renal Function in Rheumatoid Arthritis Patients

Sadia Hassan; Ferdous Towhid; Shamima Sattar; Shahedul Kabir; Kartick Chanda Shaha; Nazma Akther

doi:doi:10.11648/j.ijmcr.20230201.11

| Peer-Reviewed

Status of Renal Function in Rheumatoid Arthritis Patients

Sadia Hassan, Ferdous Towhid, Shamima Sattar, Shahedul Kabir, Kartick Chanda Shaha, Nazma Akther

Published in International Journal of Medical Case Reports (Volume 2, Issue 1)

Received: 20 December 2022 Accepted: 9 January 2023 Published: 17 January 2023

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Objective: The aim of the present study was to assess the status of renal function in rheumatoid arthritis patients. Methods: A cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2016 to June 2017. According to selection criteria one hundred subjects were selected with the age ranging from 20-60 years and equally divided into two groups. Group-A fifty diagnosed case of rheumatoid arthritis patients attending in the OPD of Arthritis Care and Research Centre and SLE Clinic, Department of Medicine, Dhaka Medical College Hospital and Group-B fifty apparently healthy individuals. The study parameters were serum creatinine, eGFR, serum urea, BMI, RA factor and anti-citrullinated protein antibody (ACPA). The results were compared statistically between two groups. Results: Serum creatinine (mg/dl) (mean ± SD) level was significantly higher (p <0.032) in RA (0.85± 0.17) than normal individuals (0.78± 0.15). Level of eGFR (ml/min/1.73m2) (mean ± SD) level was significantly lower (p <0.042) in RA (84.5 ± 20.3) than normal individuals (92.7± 19.5). Serum urea (mg/dl) (mean ± SD) level was significantly higher (p <0.011) in RA (33.12 ± 9.46) than normal individuals (28.51± 8.28). RA factor (IU/ml) and anti-citrullinated protein antibody (ACPA, U/ml) (mean ± SD) level was significantly higher (p <0.001) in RA (37.4± 13.6 and 23.5± 8.3 respectively) than normal individual (11.7± 3.25 and 7.3± 1.65 respectively). The BMI (kg/m²) (mean ± SD) was significantly higher (p <0.0001) in RA (28.5 ± 4.8) than normal individuals (21.1± 3.7). Conclusion: Serum creatinine is positively correlated to RA factor and ACPA in both groups and eGFR is negatively correlated to RA factor and ACPA in both groups. Routine screening of renal function may be beneficial for rheumatoid arthritis patients to prevent renal complications.

Published in	International Journal of Medical Case Reports (Volume 2, Issue 1)
DOI	10.11648/j.ijmcr.20230201.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Rheumatoid Arthritis, Renal Function, Anti-Citrullinated Protein Antibody, S. Creatinine

References

[1]	Aletaha, D., Neogi, T., Silman, A. J., Funovits, J. and Felson, D. T. (2010) Arthritis & rheumatism, An Official Journal of the American College of Rheumatology, 62 (9), pp. 2569-2581.
[2]	Singh, J. A., Saag, K. G., JR, S. L. B., AKI, E. A., Bannuru, R. R. (2015) 2015 American college of rheumatology guideline for the treatment of rheumatoid arthritis, Arthritis Care & Research, 4 (2), pp. 1-25.
[3]	Wasserman, A. M. (2011) Diagnosis and management of rheumatoid arthritis, Am Fam Physician, 84 (11), pp. 1245-1252.
[4]	Charpin, C., Arnoux, F., Martin, M., Toussirot, E. and Lambert, N. (2013) New autoantibodies in early rheumatoid arthritis, Arthritis Research and Therapy,15 (4), pp. 1-9.
[5]	Anders, H. J. and Vielhauer, V. (2011) Renal co-morbidity in patients with rheumatic diseases, Arthritis Research and Therapy, 13, pp. 222-225.
[6]	Pathan, E. and Joshi, V. R. (2004) Rheumatoid arthritis and the kidney, JAPI, 52, pp. 488-494.
[7]	Anderson, W. (1996) Kidneys in Anderson’s Pathology diseases, 5th edition (CV Mosby Company), St Louise BatlomorePhiladephia Toronto, pp. 610-621.
[8]	Hackenmueller, S. (2013) Laboratory evaluation of kidney function, pp. 53-55. [online]. Available at: https://www.arup.utah.edu> media >051313 kidney [Accessed 8 August, 2016].
[9]	Mirpourian, M., Salesi, M., Abdolahi, H., Farajzadegan, Z. and Karimzadeh, H. (2014) The association of body mass index with disease activity and clinical response to combination therapy in patients with rheumatoid arthritis, Journal of Research in Medical Sciences, 19, pp. 509-514.
[10]	Ayhan, F. F., Ataman, S., Rezvani, A., Paker, N. and Tastekin, N. (2016) Obesity associated with active, but preserved joints in rheumatoid arthritis: results from our national registry, Arch Rheumatol, 31 (3), pp. 272-280.
[11]	Karim, M. R. (2016) Correlation of anti-CCP antibodies with RA disease activity, pp. 6-35. [online].
[12]	Kastbom, A., Strandberg, G., Lindroos, A. and Skogh, T. (2004) Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project), Ann Rheum Dis, 63, pp. 1085-1089.
[13]	Ansari, S. K. (2016) NSAIDs and renal function in rheumatoid arthritis, Journal of Medical Science And Clinical Research, 4 (02), pp. 9412-9416.
[14]	Hill, A. J., Thomson, R. J., Hunter, J. A. and Traynor, J. P. (2009) the prevalence of chronic kidney disease in rheumatology outpatients, Scottish Medical Journal, 54 (2), pp. 9-12.

Cite This Article

Plain Text BibTeX RIS

APA Style

Sadia Hassan, Ferdous Towhid, Shamima Sattar, Shahedul Kabir, Kartick Chanda Shaha, et al. (2023). Status of Renal Function in Rheumatoid Arthritis Patients. International Journal of Medical Case Reports, 2(1), 1-4. https://doi.org/10.11648/j.ijmcr.20230201.11

Copy | Download

ACS Style

Sadia Hassan; Ferdous Towhid; Shamima Sattar; Shahedul Kabir; Kartick Chanda Shaha, et al. Status of Renal Function in Rheumatoid Arthritis Patients. Int. J. Med. Case Rep. 2023, 2(1), 1-4. doi: 10.11648/j.ijmcr.20230201.11

Copy | Download

AMA Style

Sadia Hassan, Ferdous Towhid, Shamima Sattar, Shahedul Kabir, Kartick Chanda Shaha, et al. Status of Renal Function in Rheumatoid Arthritis Patients. Int J Med Case Rep. 2023;2(1):1-4. doi: 10.11648/j.ijmcr.20230201.11

Copy | Download

@article{10.11648/j.ijmcr.20230201.11,
  author = {Sadia Hassan and Ferdous Towhid and Shamima Sattar and Shahedul Kabir and Kartick Chanda Shaha and Nazma Akther},
  title = {Status of Renal Function in Rheumatoid Arthritis Patients},
  journal = {International Journal of Medical Case Reports},
  volume = {2},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijmcr.20230201.11},
  url = {https://doi.org/10.11648/j.ijmcr.20230201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmcr.20230201.11},
  abstract = {Objective: The aim of the present study was to assess the status of renal function in rheumatoid arthritis patients. Methods: A cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2016 to June 2017. According to selection criteria one hundred subjects were selected with the age ranging from 20-60 years and equally divided into two groups. Group-A fifty diagnosed case of rheumatoid arthritis patients attending in the OPD of Arthritis Care and Research Centre and SLE Clinic, Department of Medicine, Dhaka Medical College Hospital and Group-B fifty apparently healthy individuals. The study parameters were serum creatinine, eGFR, serum urea, BMI, RA factor and anti-citrullinated protein antibody (ACPA). The results were compared statistically between two groups. Results: Serum creatinine (mg/dl) (mean ± SD) level was significantly higher (p Conclusion: Serum creatinine is positively correlated to RA factor and ACPA in both groups and eGFR is negatively correlated to RA factor and ACPA in both groups. Routine screening of renal function may be beneficial for rheumatoid arthritis patients to prevent renal complications.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Status of Renal Function in Rheumatoid Arthritis Patients
AU  - Sadia Hassan
AU  - Ferdous Towhid
AU  - Shamima Sattar
AU  - Shahedul Kabir
AU  - Kartick Chanda Shaha
AU  - Nazma Akther
Y1  - 2023/01/17
PY  - 2023
N1  - https://doi.org/10.11648/j.ijmcr.20230201.11
DO  - 10.11648/j.ijmcr.20230201.11
T2  - International Journal of Medical Case Reports
JF  - International Journal of Medical Case Reports
JO  - International Journal of Medical Case Reports
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2994-7049
UR  - https://doi.org/10.11648/j.ijmcr.20230201.11
AB  - Objective: The aim of the present study was to assess the status of renal function in rheumatoid arthritis patients. Methods: A cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2016 to June 2017. According to selection criteria one hundred subjects were selected with the age ranging from 20-60 years and equally divided into two groups. Group-A fifty diagnosed case of rheumatoid arthritis patients attending in the OPD of Arthritis Care and Research Centre and SLE Clinic, Department of Medicine, Dhaka Medical College Hospital and Group-B fifty apparently healthy individuals. The study parameters were serum creatinine, eGFR, serum urea, BMI, RA factor and anti-citrullinated protein antibody (ACPA). The results were compared statistically between two groups. Results: Serum creatinine (mg/dl) (mean ± SD) level was significantly higher (p Conclusion: Serum creatinine is positively correlated to RA factor and ACPA in both groups and eGFR is negatively correlated to RA factor and ACPA in both groups. Routine screening of renal function may be beneficial for rheumatoid arthritis patients to prevent renal complications.
VL  - 2
IS  - 1
ER  -

Copy | Download

Author Information

Sadia Hassan

Department of Biochemistry, Mainamoti Medical College, Cumilla, Bangladesh
Ferdous Towhid

Department of Biochemistry, Dhaka National Medical College, Dhaka, Bangladesh
Shamima Sattar

Department of Pharmacology, Community Based Medical College, Mymensingh, Bangladesh
Shahedul Kabir

Department of Cardiology, Cumilla Medical College, Cumilla, Bangladesh
Kartick Chanda Shaha

Department of Pharmacology, Dhaka National Medical College, Dhaka, Bangladesh
Nazma Akther

Department of Biochemistry, East west Medical College, Dhaka, Bangladesh

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Sadia Hassan, Ferdous Towhid, Shamima Sattar, Shahedul Kabir, Kartick Chanda Shaha, et al. (2023). Status of Renal Function in Rheumatoid Arthritis Patients. International Journal of Medical Case Reports, 2(1), 1-4. https://doi.org/10.11648/j.ijmcr.20230201.11

Copy | Download

ACS Style

Sadia Hassan; Ferdous Towhid; Shamima Sattar; Shahedul Kabir; Kartick Chanda Shaha, et al. Status of Renal Function in Rheumatoid Arthritis Patients. Int. J. Med. Case Rep. 2023, 2(1), 1-4. doi: 10.11648/j.ijmcr.20230201.11

Copy | Download

AMA Style

Sadia Hassan, Ferdous Towhid, Shamima Sattar, Shahedul Kabir, Kartick Chanda Shaha, et al. Status of Renal Function in Rheumatoid Arthritis Patients. Int J Med Case Rep. 2023;2(1):1-4. doi: 10.11648/j.ijmcr.20230201.11

Copy | Download

@article{10.11648/j.ijmcr.20230201.11,
  author = {Sadia Hassan and Ferdous Towhid and Shamima Sattar and Shahedul Kabir and Kartick Chanda Shaha and Nazma Akther},
  title = {Status of Renal Function in Rheumatoid Arthritis Patients},
  journal = {International Journal of Medical Case Reports},
  volume = {2},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijmcr.20230201.11},
  url = {https://doi.org/10.11648/j.ijmcr.20230201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmcr.20230201.11},
  abstract = {Objective: The aim of the present study was to assess the status of renal function in rheumatoid arthritis patients. Methods: A cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2016 to June 2017. According to selection criteria one hundred subjects were selected with the age ranging from 20-60 years and equally divided into two groups. Group-A fifty diagnosed case of rheumatoid arthritis patients attending in the OPD of Arthritis Care and Research Centre and SLE Clinic, Department of Medicine, Dhaka Medical College Hospital and Group-B fifty apparently healthy individuals. The study parameters were serum creatinine, eGFR, serum urea, BMI, RA factor and anti-citrullinated protein antibody (ACPA). The results were compared statistically between two groups. Results: Serum creatinine (mg/dl) (mean ± SD) level was significantly higher (p Conclusion: Serum creatinine is positively correlated to RA factor and ACPA in both groups and eGFR is negatively correlated to RA factor and ACPA in both groups. Routine screening of renal function may be beneficial for rheumatoid arthritis patients to prevent renal complications.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Status of Renal Function in Rheumatoid Arthritis Patients
AU  - Sadia Hassan
AU  - Ferdous Towhid
AU  - Shamima Sattar
AU  - Shahedul Kabir
AU  - Kartick Chanda Shaha
AU  - Nazma Akther
Y1  - 2023/01/17
PY  - 2023
N1  - https://doi.org/10.11648/j.ijmcr.20230201.11
DO  - 10.11648/j.ijmcr.20230201.11
T2  - International Journal of Medical Case Reports
JF  - International Journal of Medical Case Reports
JO  - International Journal of Medical Case Reports
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2994-7049
UR  - https://doi.org/10.11648/j.ijmcr.20230201.11
AB  - Objective: The aim of the present study was to assess the status of renal function in rheumatoid arthritis patients. Methods: A cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2016 to June 2017. According to selection criteria one hundred subjects were selected with the age ranging from 20-60 years and equally divided into two groups. Group-A fifty diagnosed case of rheumatoid arthritis patients attending in the OPD of Arthritis Care and Research Centre and SLE Clinic, Department of Medicine, Dhaka Medical College Hospital and Group-B fifty apparently healthy individuals. The study parameters were serum creatinine, eGFR, serum urea, BMI, RA factor and anti-citrullinated protein antibody (ACPA). The results were compared statistically between two groups. Results: Serum creatinine (mg/dl) (mean ± SD) level was significantly higher (p Conclusion: Serum creatinine is positively correlated to RA factor and ACPA in both groups and eGFR is negatively correlated to RA factor and ACPA in both groups. Routine screening of renal function may be beneficial for rheumatoid arthritis patients to prevent renal complications.
VL  - 2
IS  - 1
ER  -

Copy | Download