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Outcome Comparison Between Tocilizumab Alone Vs Tocilizumab Followed by Intravenous Immunoglobulin (IVIG) Group in Critical COVID-19 Disease

Received: 23 October 2020     Accepted: 18 January 2021     Published: 27 February 2021
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Abstract

Currently, COVID-19 is one of the most pressing healthcare problems across the world. With no definitive pharmacological guidelines, multiple drugs were used to treat critical patients with little success. of Tocilizumab, a monoclonal antibody has shown some role in the treatment of Covid-19 infection. The study was a cross-sectional prospective observational study. It was conducted in the COVID-19 Intensive Care Unit (ICU) of Liaquat National Hospital and Medical College, and National Medical Centre Karachi. The study was conducted from 15th June 2020 to 31st July 2020. Objective of the study was to compare the outcomes of severe to critical COVID-19 patients with established Cytokine release Syndrome (CRS), who received Tocilizumab with the group received Tocilizumab followed by intravenous immunoglobulins (IVIG). Two groups were made with one receiving Tocilizumab alone while the other received IVIG after Tocilizumab. Comparison was then made based on frequency of mortality as well the need of mechanical ventilation and its range of days. In results 4 (15.4%) patients in Tocilizumab only group died while Tocilizumab followed by IVIG treated group had 10 (38.46%) deaths. 20 (76.9%) patients needed mechanical ventilation in Tocilizumab only group while Tocilizumab followed by IVIG treated group consisted of 23 (88.46%) patients. This concludes that the group with only Tocilizumab therapy has better outcome as compare to the group who received both Tocilizumab and intravenous immunoglobulins.

Published in International Journal of Infectious Diseases and Therapy (Volume 6, Issue 1)
DOI 10.11648/j.ijidt.20210601.15
Page(s) 37-40
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

COVID-19, Coronavirus, Tocilizumab, Immunoglobulin

References
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Cite This Article
  • APA Style

    Syeda Rida-e-Zehra, Shamim Kausar, Anum Latif, Samar Abbas Jaffri, Syeda Namayah Fatima Hussain, et al. (2021). Outcome Comparison Between Tocilizumab Alone Vs Tocilizumab Followed by Intravenous Immunoglobulin (IVIG) Group in Critical COVID-19 Disease. International Journal of Infectious Diseases and Therapy, 6(1), 37-40. https://doi.org/10.11648/j.ijidt.20210601.15

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    ACS Style

    Syeda Rida-e-Zehra; Shamim Kausar; Anum Latif; Samar Abbas Jaffri; Syeda Namayah Fatima Hussain, et al. Outcome Comparison Between Tocilizumab Alone Vs Tocilizumab Followed by Intravenous Immunoglobulin (IVIG) Group in Critical COVID-19 Disease. Int. J. Infect. Dis. Ther. 2021, 6(1), 37-40. doi: 10.11648/j.ijidt.20210601.15

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    AMA Style

    Syeda Rida-e-Zehra, Shamim Kausar, Anum Latif, Samar Abbas Jaffri, Syeda Namayah Fatima Hussain, et al. Outcome Comparison Between Tocilizumab Alone Vs Tocilizumab Followed by Intravenous Immunoglobulin (IVIG) Group in Critical COVID-19 Disease. Int J Infect Dis Ther. 2021;6(1):37-40. doi: 10.11648/j.ijidt.20210601.15

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  • @article{10.11648/j.ijidt.20210601.15,
      author = {Syeda Rida-e-Zehra and Shamim Kausar and Anum Latif and Samar Abbas Jaffri and Syeda Namayah Fatima Hussain and Irfan Ahsan and Muhammad Rafay and Pirih Bhatti},
      title = {Outcome Comparison Between Tocilizumab Alone Vs Tocilizumab Followed by Intravenous Immunoglobulin (IVIG) Group in Critical COVID-19 Disease},
      journal = {International Journal of Infectious Diseases and Therapy},
      volume = {6},
      number = {1},
      pages = {37-40},
      doi = {10.11648/j.ijidt.20210601.15},
      url = {https://doi.org/10.11648/j.ijidt.20210601.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20210601.15},
      abstract = {Currently, COVID-19 is one of the most pressing healthcare problems across the world. With no definitive pharmacological guidelines, multiple drugs were used to treat critical patients with little success. of Tocilizumab, a monoclonal antibody has shown some role in the treatment of Covid-19 infection. The study was a cross-sectional prospective observational study. It was conducted in the COVID-19 Intensive Care Unit (ICU) of Liaquat National Hospital and Medical College, and National Medical Centre Karachi. The study was conducted from 15th June 2020 to 31st July 2020. Objective of the study was to compare the outcomes of severe to critical COVID-19 patients with established Cytokine release Syndrome (CRS), who received Tocilizumab with the group received Tocilizumab followed by intravenous immunoglobulins (IVIG). Two groups were made with one receiving Tocilizumab alone while the other received IVIG after Tocilizumab. Comparison was then made based on frequency of mortality as well the need of mechanical ventilation and its range of days. In results 4 (15.4%) patients in Tocilizumab only group died while Tocilizumab followed by IVIG treated group had 10 (38.46%) deaths. 20 (76.9%) patients needed mechanical ventilation in Tocilizumab only group while Tocilizumab followed by IVIG treated group consisted of 23 (88.46%) patients. This concludes that the group with only Tocilizumab therapy has better outcome as compare to the group who received both Tocilizumab and intravenous immunoglobulins.},
     year = {2021}
    }
    

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    AU  - Syeda Rida-e-Zehra
    AU  - Shamim Kausar
    AU  - Anum Latif
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    AU  - Irfan Ahsan
    AU  - Muhammad Rafay
    AU  - Pirih Bhatti
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    JF  - International Journal of Infectious Diseases and Therapy
    JO  - International Journal of Infectious Diseases and Therapy
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    AB  - Currently, COVID-19 is one of the most pressing healthcare problems across the world. With no definitive pharmacological guidelines, multiple drugs were used to treat critical patients with little success. of Tocilizumab, a monoclonal antibody has shown some role in the treatment of Covid-19 infection. The study was a cross-sectional prospective observational study. It was conducted in the COVID-19 Intensive Care Unit (ICU) of Liaquat National Hospital and Medical College, and National Medical Centre Karachi. The study was conducted from 15th June 2020 to 31st July 2020. Objective of the study was to compare the outcomes of severe to critical COVID-19 patients with established Cytokine release Syndrome (CRS), who received Tocilizumab with the group received Tocilizumab followed by intravenous immunoglobulins (IVIG). Two groups were made with one receiving Tocilizumab alone while the other received IVIG after Tocilizumab. Comparison was then made based on frequency of mortality as well the need of mechanical ventilation and its range of days. In results 4 (15.4%) patients in Tocilizumab only group died while Tocilizumab followed by IVIG treated group had 10 (38.46%) deaths. 20 (76.9%) patients needed mechanical ventilation in Tocilizumab only group while Tocilizumab followed by IVIG treated group consisted of 23 (88.46%) patients. This concludes that the group with only Tocilizumab therapy has better outcome as compare to the group who received both Tocilizumab and intravenous immunoglobulins.
    VL  - 6
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Author Information
  • Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan

  • Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan

  • Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan

  • Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan

  • Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan

  • Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan

  • Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan

  • Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan

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