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Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria

Received: 26 July 2019     Accepted: 20 August 2019     Published: 6 September 2019
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Abstract

A prospective patient surveillance and analysis in three urban hospitals with the objective of comparing the mortality rates among patients with antimicrobials-sensitive versus -resistant gram-negative bacterial bloodstream infections. The analysis focused on the rates of in-hospital and 28-days mortality. There were 189 patients with BSI, drug-susceptible gram-negative bacteria (DSGNB) 40.7%, multi-drug resistant bacteria (MDRGNB) 42.3% and extensive-drug resistant bacteria (XDRGNB) 16.9%. The mean age, gender, SOFA score on the initial evaluation, APACHE II score, comorbidities, identified bacterial species, and BSI-associated diagnoses were not statistically different except for VAP (P = 0.000) in the XDRGNB infected patients. In-hospital and 28-days mortalities were significantly higher in the XDRGNB-BSI group (P = 0.000), and ICU length of stay (P = 0.000). XDRGNB-BSI was significantly higher in inappropriate and delayed treated patients (P < 0.05). Logistic regression analysis demonstrated no significant interaction for the 28 days mortality neither with the admission diagnoses, the antimicrobial class (except aminoglycosides), the comorbidities (except for solid tumors) (P > 0.05, Nagelkerke R2 < 0.4). In conclusion, BSI due to multiple class antimicrobial resistance has higher mortality and ICU length of stay.

Published in International Journal of Infectious Diseases and Therapy (Volume 4, Issue 3)
DOI 10.11648/j.ijidt.20190403.11
Page(s) 33-39
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Multidrug-resistant Bacteria, Extensive Drug-resistant Bacteria, Bloodstream Infection, Appropriate Therapy, ICU Length of Stay

References
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Cite This Article
  • APA Style

    Jamal Wadi Al Ramahi, Ahmad Al-Abdouh, Nour Hasan, Ghayda Haddad, Mohammad Al Baba, et al. (2019). Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria. International Journal of Infectious Diseases and Therapy, 4(3), 33-39. https://doi.org/10.11648/j.ijidt.20190403.11

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    ACS Style

    Jamal Wadi Al Ramahi; Ahmad Al-Abdouh; Nour Hasan; Ghayda Haddad; Mohammad Al Baba, et al. Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria. Int. J. Infect. Dis. Ther. 2019, 4(3), 33-39. doi: 10.11648/j.ijidt.20190403.11

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    AMA Style

    Jamal Wadi Al Ramahi, Ahmad Al-Abdouh, Nour Hasan, Ghayda Haddad, Mohammad Al Baba, et al. Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria. Int J Infect Dis Ther. 2019;4(3):33-39. doi: 10.11648/j.ijidt.20190403.11

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  • @article{10.11648/j.ijidt.20190403.11,
      author = {Jamal Wadi Al Ramahi and Ahmad Al-Abdouh and Nour Hasan and Ghayda Haddad and Mohammad Al Baba and Ahmad Al Aaraj and Mahmoud Fakhri and Lamya Abu Shanab and Belal Harara and Mahmoud Barbarawi},
      title = {Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria},
      journal = {International Journal of Infectious Diseases and Therapy},
      volume = {4},
      number = {3},
      pages = {33-39},
      doi = {10.11648/j.ijidt.20190403.11},
      url = {https://doi.org/10.11648/j.ijidt.20190403.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20190403.11},
      abstract = {A prospective patient surveillance and analysis in three urban hospitals with the objective of comparing the mortality rates among patients with antimicrobials-sensitive versus -resistant gram-negative bacterial bloodstream infections. The analysis focused on the rates of in-hospital and 28-days mortality. There were 189 patients with BSI, drug-susceptible gram-negative bacteria (DSGNB) 40.7%, multi-drug resistant bacteria (MDRGNB) 42.3% and extensive-drug resistant bacteria (XDRGNB) 16.9%. The mean age, gender, SOFA score on the initial evaluation, APACHE II score, comorbidities, identified bacterial species, and BSI-associated diagnoses were not statistically different except for VAP (P = 0.000) in the XDRGNB infected patients. In-hospital and 28-days mortalities were significantly higher in the XDRGNB-BSI group (P = 0.000), and ICU length of stay (P = 0.000). XDRGNB-BSI was significantly higher in inappropriate and delayed treated patients (P  0.05, Nagelkerke R2 < 0.4). In conclusion, BSI due to multiple class antimicrobial resistance has higher mortality and ICU length of stay.},
     year = {2019}
    }
    

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    T1  - Mortality and Length of Stay in Patients with Bloodstream Infections Due to Drug-Susceptible Versus Drug-Resistant Gram-Negative Bacteria
    AU  - Jamal Wadi Al Ramahi
    AU  - Ahmad Al-Abdouh
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    AB  - A prospective patient surveillance and analysis in three urban hospitals with the objective of comparing the mortality rates among patients with antimicrobials-sensitive versus -resistant gram-negative bacterial bloodstream infections. The analysis focused on the rates of in-hospital and 28-days mortality. There were 189 patients with BSI, drug-susceptible gram-negative bacteria (DSGNB) 40.7%, multi-drug resistant bacteria (MDRGNB) 42.3% and extensive-drug resistant bacteria (XDRGNB) 16.9%. The mean age, gender, SOFA score on the initial evaluation, APACHE II score, comorbidities, identified bacterial species, and BSI-associated diagnoses were not statistically different except for VAP (P = 0.000) in the XDRGNB infected patients. In-hospital and 28-days mortalities were significantly higher in the XDRGNB-BSI group (P = 0.000), and ICU length of stay (P = 0.000). XDRGNB-BSI was significantly higher in inappropriate and delayed treated patients (P  0.05, Nagelkerke R2 < 0.4). In conclusion, BSI due to multiple class antimicrobial resistance has higher mortality and ICU length of stay.
    VL  - 4
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Author Information
  • Department of Medicine, School of Medicine, University of Jordan, Amman, Jordan

  • Department of Internal Medicine, Al Takhassusi Hospital, Amman, Jordan

  • Department of Pharmacy, Al Khalidi Hospital, Amman, Jordan

  • Department of Pharmacy, Al Khalidi Hospital, Amman, Jordan

  • Department of Internal Medicine, Al Takhassusi Hospital, Amman, Jordan

  • Department of Internal Medicine, Al Takhassusi Hospital, Amman, Jordan

  • Department of Medicine, Jordan Hospital, Amman, Jordan

  • Department of Pharmacy, Jordan Hospital, Amman, Jordan

  • Department of Intensive Care Unit, Al Khalidi Hospital, Amman, Jordan

  • Department of Internal Medicine, Al Takhassusi Hospital, Amman, Jordan

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