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Endocrine Disruptor Compounds (EDC) Effects on Reproduction

Received: 25 March 2018     Accepted: 12 April 2018     Published: 14 May 2018
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Abstract

A large number of industrial chemical products (paints, flame retardants, pharmaceuticals, pesticides) are suspected or proved to act as endocrine disruptor compounds (EDCs). In the present survey of the literature, the main issue is to consider how to classify individual products as EDC or not. In this perspective, the different mechanisms leading to endocrine disruption are described: either by direct interaction with hormone receptors leading to its stimulation or inhibition, or by effect on endogenous hormone concentration through stimulation or inhibition of its synthesis or its degradation, or its binding to transport binding proteins. The present review takes particularly in consideration the effects of EDCs on the endocrine control of Reproduction in human and animals. Indeed, a number of EDCs can act as anti-androgens, anti-estrogens, and steroidogenic enzyme inhibitors that interfere with steroid action or production and thus can alter reproductive health.

Published in International Journal of Diabetes and Endocrinology (Volume 3, Issue 1)
DOI 10.11648/j.ijde.20180301.14
Page(s) 18-22
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Endocrine Disruption, Endogenous Hormone, Reproduction, Reproductive Health

References
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  • APA Style

    Thi Mong Diep Nguyen. (2018). Endocrine Disruptor Compounds (EDC) Effects on Reproduction. International Journal of Diabetes and Endocrinology, 3(1), 18-22. https://doi.org/10.11648/j.ijde.20180301.14

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    ACS Style

    Thi Mong Diep Nguyen. Endocrine Disruptor Compounds (EDC) Effects on Reproduction. Int. J. Diabetes Endocrinol. 2018, 3(1), 18-22. doi: 10.11648/j.ijde.20180301.14

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    AMA Style

    Thi Mong Diep Nguyen. Endocrine Disruptor Compounds (EDC) Effects on Reproduction. Int J Diabetes Endocrinol. 2018;3(1):18-22. doi: 10.11648/j.ijde.20180301.14

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  • @article{10.11648/j.ijde.20180301.14,
      author = {Thi Mong Diep Nguyen},
      title = {Endocrine Disruptor Compounds (EDC) Effects on Reproduction},
      journal = {International Journal of Diabetes and Endocrinology},
      volume = {3},
      number = {1},
      pages = {18-22},
      doi = {10.11648/j.ijde.20180301.14},
      url = {https://doi.org/10.11648/j.ijde.20180301.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20180301.14},
      abstract = {A large number of industrial chemical products (paints, flame retardants, pharmaceuticals, pesticides) are suspected or proved to act as endocrine disruptor compounds (EDCs). In the present survey of the literature, the main issue is to consider how to classify individual products as EDC or not. In this perspective, the different mechanisms leading to endocrine disruption are described: either by direct interaction with hormone receptors leading to its stimulation or inhibition, or by effect on endogenous hormone concentration through stimulation or inhibition of its synthesis or its degradation, or its binding to transport binding proteins. The present review takes particularly in consideration the effects of EDCs on the endocrine control of Reproduction in human and animals. Indeed, a number of EDCs can act as anti-androgens, anti-estrogens, and steroidogenic enzyme inhibitors that interfere with steroid action or production and thus can alter reproductive health.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Endocrine Disruptor Compounds (EDC) Effects on Reproduction
    AU  - Thi Mong Diep Nguyen
    Y1  - 2018/05/14
    PY  - 2018
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    DO  - 10.11648/j.ijde.20180301.14
    T2  - International Journal of Diabetes and Endocrinology
    JF  - International Journal of Diabetes and Endocrinology
    JO  - International Journal of Diabetes and Endocrinology
    SP  - 18
    EP  - 22
    PB  - Science Publishing Group
    SN  - 2640-1371
    UR  - https://doi.org/10.11648/j.ijde.20180301.14
    AB  - A large number of industrial chemical products (paints, flame retardants, pharmaceuticals, pesticides) are suspected or proved to act as endocrine disruptor compounds (EDCs). In the present survey of the literature, the main issue is to consider how to classify individual products as EDC or not. In this perspective, the different mechanisms leading to endocrine disruption are described: either by direct interaction with hormone receptors leading to its stimulation or inhibition, or by effect on endogenous hormone concentration through stimulation or inhibition of its synthesis or its degradation, or its binding to transport binding proteins. The present review takes particularly in consideration the effects of EDCs on the endocrine control of Reproduction in human and animals. Indeed, a number of EDCs can act as anti-androgens, anti-estrogens, and steroidogenic enzyme inhibitors that interfere with steroid action or production and thus can alter reproductive health.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Faculty of Biology-Agricultural Engineering, Quy Nhon University, Quy Nhon, Viet Nam

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