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Preventive Effect of Phloretin on Components of Glycoprotein Changes in Streptozotocin Induced Diabetic Rats

Received: 28 February 2017     Accepted: 28 April 2017     Published: 3 July 2017
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Abstract

The present study was aimed to evaluate the protective effect of phloretin on glycoprotein components in serum and tissues of streptozotocin induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (60 mg/kg b.w). Phloretin (25mg and 50mg/kg b.w) was administered orally to diabetic rats for 45 days. The effect of phloretin on serum glucose, glycated hemoglobin, serum and tissue glycoprotein components were studied. Phloretin administration to diabetic rats decreased the level of glucose, glycated hemoglobin and glycoprotein components in serum. There was observed a significant decrease in the level of sialic acid and significantly elevated levels of hexose, hexosamine and fucose in liver and kidney of diabetic rats. The altered levels of serum and tissue glycoprotein components were restored to near normal in diabetic rats treated with phloretin at 50mg/kg b.w. The present findings suggest that phloretin can potentially ameliorates the hyperglycemia and changes in glycoprotein components abnormalities in streptozotocin induced diabetic rats. So, the phloretin may be used as an effective therapeutic agent for diabetes mellitus in future.

Published in International Journal of Diabetes and Endocrinology (Volume 2, Issue 2)
DOI 10.11648/j.ijde.20170202.13
Page(s) 30-35
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Streptozotocin, Diabetes Mellitus, Phloretin, Glycoprotein

References
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    Tamilarasan Nithiya, Rajangam Udayakumar. (2017). Preventive Effect of Phloretin on Components of Glycoprotein Changes in Streptozotocin Induced Diabetic Rats. International Journal of Diabetes and Endocrinology, 2(2), 30-35. https://doi.org/10.11648/j.ijde.20170202.13

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    ACS Style

    Tamilarasan Nithiya; Rajangam Udayakumar. Preventive Effect of Phloretin on Components of Glycoprotein Changes in Streptozotocin Induced Diabetic Rats. Int. J. Diabetes Endocrinol. 2017, 2(2), 30-35. doi: 10.11648/j.ijde.20170202.13

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    AMA Style

    Tamilarasan Nithiya, Rajangam Udayakumar. Preventive Effect of Phloretin on Components of Glycoprotein Changes in Streptozotocin Induced Diabetic Rats. Int J Diabetes Endocrinol. 2017;2(2):30-35. doi: 10.11648/j.ijde.20170202.13

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  • @article{10.11648/j.ijde.20170202.13,
      author = {Tamilarasan Nithiya and Rajangam Udayakumar},
      title = {Preventive Effect of Phloretin on Components of Glycoprotein Changes in Streptozotocin Induced Diabetic Rats},
      journal = {International Journal of Diabetes and Endocrinology},
      volume = {2},
      number = {2},
      pages = {30-35},
      doi = {10.11648/j.ijde.20170202.13},
      url = {https://doi.org/10.11648/j.ijde.20170202.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20170202.13},
      abstract = {The present study was aimed to evaluate the protective effect of phloretin on glycoprotein components in serum and tissues of streptozotocin induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (60 mg/kg b.w). Phloretin (25mg and 50mg/kg b.w) was administered orally to diabetic rats for 45 days. The effect of phloretin on serum glucose, glycated hemoglobin, serum and tissue glycoprotein components were studied. Phloretin administration to diabetic rats decreased the level of glucose, glycated hemoglobin and glycoprotein components in serum. There was observed a significant decrease in the level of sialic acid and significantly elevated levels of hexose, hexosamine and fucose in liver and kidney of diabetic rats. The altered levels of serum and tissue glycoprotein components were restored to near normal in diabetic rats treated with phloretin at 50mg/kg b.w. The present findings suggest that phloretin can potentially ameliorates the hyperglycemia and changes in glycoprotein components abnormalities in streptozotocin induced diabetic rats. So, the phloretin may be used as an effective therapeutic agent for diabetes mellitus in future.},
     year = {2017}
    }
    

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    T1  - Preventive Effect of Phloretin on Components of Glycoprotein Changes in Streptozotocin Induced Diabetic Rats
    AU  - Tamilarasan Nithiya
    AU  - Rajangam Udayakumar
    Y1  - 2017/07/03
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    N1  - https://doi.org/10.11648/j.ijde.20170202.13
    DO  - 10.11648/j.ijde.20170202.13
    T2  - International Journal of Diabetes and Endocrinology
    JF  - International Journal of Diabetes and Endocrinology
    JO  - International Journal of Diabetes and Endocrinology
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    EP  - 35
    PB  - Science Publishing Group
    SN  - 2640-1371
    UR  - https://doi.org/10.11648/j.ijde.20170202.13
    AB  - The present study was aimed to evaluate the protective effect of phloretin on glycoprotein components in serum and tissues of streptozotocin induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (60 mg/kg b.w). Phloretin (25mg and 50mg/kg b.w) was administered orally to diabetic rats for 45 days. The effect of phloretin on serum glucose, glycated hemoglobin, serum and tissue glycoprotein components were studied. Phloretin administration to diabetic rats decreased the level of glucose, glycated hemoglobin and glycoprotein components in serum. There was observed a significant decrease in the level of sialic acid and significantly elevated levels of hexose, hexosamine and fucose in liver and kidney of diabetic rats. The altered levels of serum and tissue glycoprotein components were restored to near normal in diabetic rats treated with phloretin at 50mg/kg b.w. The present findings suggest that phloretin can potentially ameliorates the hyperglycemia and changes in glycoprotein components abnormalities in streptozotocin induced diabetic rats. So, the phloretin may be used as an effective therapeutic agent for diabetes mellitus in future.
    VL  - 2
    IS  - 2
    ER  - 

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Author Information
  • Department of Biochemistry, Government Arts College (Autonomous), Kumbakonam, Tamilnadu, India

  • Department of Biochemistry, Government Arts College (Autonomous), Kumbakonam, Tamilnadu, India

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