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Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus

Received: 4 November 2016     Accepted: 2 December 2016     Published: 27 December 2016
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Abstract

Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.

Published in International Journal of Diabetes and Endocrinology (Volume 1, Issue 1)
DOI 10.11648/j.ijde.20160101.12
Page(s) 8-12
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Testosterone, Metformin, Glyburide, Type 2DM

References
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Cite This Article
  • APA Style

    Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Salah A. Al-Windy. (2016). Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus. International Journal of Diabetes and Endocrinology, 1(1), 8-12. https://doi.org/10.11648/j.ijde.20160101.12

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    ACS Style

    Hayder M. Al-kuraishy; Ali I. Al-Gareeb; Salah A. Al-Windy. Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus. Int. J. Diabetes Endocrinol. 2016, 1(1), 8-12. doi: 10.11648/j.ijde.20160101.12

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    AMA Style

    Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Salah A. Al-Windy. Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus. Int J Diabetes Endocrinol. 2016;1(1):8-12. doi: 10.11648/j.ijde.20160101.12

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  • @article{10.11648/j.ijde.20160101.12,
      author = {Hayder M. Al-kuraishy and Ali I. Al-Gareeb and Salah A. Al-Windy},
      title = {Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus},
      journal = {International Journal of Diabetes and Endocrinology},
      volume = {1},
      number = {1},
      pages = {8-12},
      doi = {10.11648/j.ijde.20160101.12},
      url = {https://doi.org/10.11648/j.ijde.20160101.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20160101.12},
      abstract = {Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.},
     year = {2016}
    }
    

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    T1  - Evaluation the Effect of Glyburide and/or Metformin on Testosterone Levels in Men Patients with Type 2 Diabetes Mellitus
    AU  - Hayder M. Al-kuraishy
    AU  - Ali I. Al-Gareeb
    AU  - Salah A. Al-Windy
    Y1  - 2016/12/27
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    N1  - https://doi.org/10.11648/j.ijde.20160101.12
    DO  - 10.11648/j.ijde.20160101.12
    T2  - International Journal of Diabetes and Endocrinology
    JF  - International Journal of Diabetes and Endocrinology
    JO  - International Journal of Diabetes and Endocrinology
    SP  - 8
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    PB  - Science Publishing Group
    SN  - 2640-1371
    UR  - https://doi.org/10.11648/j.ijde.20160101.12
    AB  - Low testosterone serum levels have been linked with pathogenesis of type 2DM. Type 2DM pharmacotherapy may also affect the testosterone levels since; metformin decreases testosterone levels, whereas glyburide might increase the testosterone levels. Sixty-one men patients with type 2DM were selected: 22 of patients were treated with metformin, 20 of patients were treated with glyburide and 19 patients were treated with glyburide plus metformin the duration of disease was 3-6 years, compared with 20 normal healthy volunteers. Total testosterone, free testosterone and other biochemical measures as well as anthropometric variables were evaluated in each treated group. In glyburide or metformin treated patients, there were significant reduction in testosterone serum levels regarding the total and free testosterone p<0.01whereas patients that were treated with combined glyburide plus metformin there was an insignificant reduction in both total and free testosterone p>0.5. Conclusion: Combined therapy of metformin plus glyburide in type 2DM lead to a significant increment in the testosterone levels, which may play an important role in the amelioration of metabolic complications that are induced by type 2 DM.
    VL  - 1
    IS  - 1
    ER  - 

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Author Information
  • Department of Pharmacology, Toxicology and Medicine College of Medicine, Almustansiriya University, Baghdad, Iraq

  • Department of Pharmacology, Toxicology and Medicine College of Medicine, Almustansiriya University, Baghdad, Iraq

  • Department of Biology and Biochemistry, College of Sciences, Baghdad University, Baghdad, Iraq

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