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Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report

Received: 28 March 2023     Accepted: 2 May 2023     Published: 31 July 2023
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Abstract

Objectives: Primary prostatic malignant lymphoma is an exceedingly rare malignancy, accounting for only 0.09% of all prostate neoplasms and 0.1% of all non-Hodgkin's lymphomas. In this report, we present a case of a 70-year-old male patient who presented with sudden-onset hematuria and was ultimately diagnosed with primary lymphoma of the prostate. Methods: The patient presented to a urology outpatient clinic with a 2-week history of gross hematuria but no lower urinary tract symptoms. Digital rectal examination revealed a firm and enlarged prostate, and serum PSA levels were elevated. Ultrasound evaluation, multiparametric prostate magnetic resonance imaging (mp-MRI), and cystoscopy were performed, revealing only a grossly enlarged prostatic median lobe. A systematic transrectal ultrasound (TRUS)-guided prostate biopsy was then performed and confirmed the diagnosis of primary lymphoma of the prostate. Results & Conclusion: This case highlights the importance of considering primary lymphoma of the prostate in patients presenting with macroscopic hematuria and an enlarged prostate, even if mp-MRI does not reveal any other abnormalities. Early diagnosis is crucial in such cases, as it allows for prompt initiation of treatment and may improve clinical outcomes. Given the rarity of this malignancy, clinicians must remain vigilant for its possible presentation and include it in the differential diagnosis when appropriate.

Published in International Journal of Clinical Urology (Volume 7, Issue 2)
DOI 10.11648/j.ijcu.20230702.13
Page(s) 40-43
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Prostate, Lymphoma, Hematuria

References
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[4] Sarris A, Dimopoulos M, Pugh W, Cabanillas F. Primary lymphoma of the prostate: good outcome with doxorubicin-based combination chemotherapy. J Urol. 1995; 153 (6): 1852-1854.
[5] Terris MK, Hausdorff J, Freiha FS. Hematolymphoid malignancies diagnosed at the time of radical prostatectomy. J Urol. 1997; 158 (4): 1457-1459.
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[8] Steuter J, Weisenburger DD, Bociek RG, Bierman P, Vose J, Bast M, Loberiza F, et al. Non-Hodgkin lymphoma of the prostate. Am J Hematol. 2011; 86 (11): 952-954.
[9] Gorgel SN, Sefik E, Olgunelma V, Sahin E, Balci U, Calli AO. Primary non-Hodgkin follicular lymphoma of the prostate: A case report. Turk J Urol. 2014; 40 (1): 57-58.
[10] Alongi F, Aniko MD, Ferreri AJ, Rosso A, Cozzarini C, Fallanca F, Berardi G, et al. Consolidation radiotherapy for a rare case of extranodal mucosa-associated lymphoid tissue non-Hodgkin's lymphoma synchronous with prostate adenocarcinoma. Tumori. 2010; 96 (3): 498-502.
[11] Xu M, Yang Q, Li M, Geng W, Huang W, Chen Y. Prostate involvement by intravascular large B-cell lymphoma: a case report with literature review. Int J Surg Pathol. 2011; 19 (4): 544-547.
[12] Johnson TR, Barber DB, Teichman JM, Able AC. T-cell lymphocytic lymphoma involving the prostate presenting as elevated PSA in paraplegia: case report. J Spinal Cord Med. 1996; 19 (4): 258-260.
[13] Taleb A, Ismaili N, Belbaraka R, Bensouda A, Elghissassi I, Elmesbahi O, Droz JP, et al. Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature. Cases J. 2009; 2: 8875.
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  • APA Style

    Ibrahim Hacibey, Esat Kaba, Sule Ozsoy, Emrah Yuruk, Ahmet Yaser Muslumanoglu. (2023). Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report. International Journal of Clinical Urology, 7(2), 40-43. https://doi.org/10.11648/j.ijcu.20230702.13

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    ACS Style

    Ibrahim Hacibey; Esat Kaba; Sule Ozsoy; Emrah Yuruk; Ahmet Yaser Muslumanoglu. Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report. Int. J. Clin. Urol. 2023, 7(2), 40-43. doi: 10.11648/j.ijcu.20230702.13

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    AMA Style

    Ibrahim Hacibey, Esat Kaba, Sule Ozsoy, Emrah Yuruk, Ahmet Yaser Muslumanoglu. Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report. Int J Clin Urol. 2023;7(2):40-43. doi: 10.11648/j.ijcu.20230702.13

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  • @article{10.11648/j.ijcu.20230702.13,
      author = {Ibrahim Hacibey and Esat Kaba and Sule Ozsoy and Emrah Yuruk and Ahmet Yaser Muslumanoglu},
      title = {Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report},
      journal = {International Journal of Clinical Urology},
      volume = {7},
      number = {2},
      pages = {40-43},
      doi = {10.11648/j.ijcu.20230702.13},
      url = {https://doi.org/10.11648/j.ijcu.20230702.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcu.20230702.13},
      abstract = {Objectives: Primary prostatic malignant lymphoma is an exceedingly rare malignancy, accounting for only 0.09% of all prostate neoplasms and 0.1% of all non-Hodgkin's lymphomas. In this report, we present a case of a 70-year-old male patient who presented with sudden-onset hematuria and was ultimately diagnosed with primary lymphoma of the prostate. Methods: The patient presented to a urology outpatient clinic with a 2-week history of gross hematuria but no lower urinary tract symptoms. Digital rectal examination revealed a firm and enlarged prostate, and serum PSA levels were elevated. Ultrasound evaluation, multiparametric prostate magnetic resonance imaging (mp-MRI), and cystoscopy were performed, revealing only a grossly enlarged prostatic median lobe. A systematic transrectal ultrasound (TRUS)-guided prostate biopsy was then performed and confirmed the diagnosis of primary lymphoma of the prostate. Results & Conclusion: This case highlights the importance of considering primary lymphoma of the prostate in patients presenting with macroscopic hematuria and an enlarged prostate, even if mp-MRI does not reveal any other abnormalities. Early diagnosis is crucial in such cases, as it allows for prompt initiation of treatment and may improve clinical outcomes. Given the rarity of this malignancy, clinicians must remain vigilant for its possible presentation and include it in the differential diagnosis when appropriate.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report
    AU  - Ibrahim Hacibey
    AU  - Esat Kaba
    AU  - Sule Ozsoy
    AU  - Emrah Yuruk
    AU  - Ahmet Yaser Muslumanoglu
    Y1  - 2023/07/31
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ijcu.20230702.13
    DO  - 10.11648/j.ijcu.20230702.13
    T2  - International Journal of Clinical Urology
    JF  - International Journal of Clinical Urology
    JO  - International Journal of Clinical Urology
    SP  - 40
    EP  - 43
    PB  - Science Publishing Group
    SN  - 2640-1355
    UR  - https://doi.org/10.11648/j.ijcu.20230702.13
    AB  - Objectives: Primary prostatic malignant lymphoma is an exceedingly rare malignancy, accounting for only 0.09% of all prostate neoplasms and 0.1% of all non-Hodgkin's lymphomas. In this report, we present a case of a 70-year-old male patient who presented with sudden-onset hematuria and was ultimately diagnosed with primary lymphoma of the prostate. Methods: The patient presented to a urology outpatient clinic with a 2-week history of gross hematuria but no lower urinary tract symptoms. Digital rectal examination revealed a firm and enlarged prostate, and serum PSA levels were elevated. Ultrasound evaluation, multiparametric prostate magnetic resonance imaging (mp-MRI), and cystoscopy were performed, revealing only a grossly enlarged prostatic median lobe. A systematic transrectal ultrasound (TRUS)-guided prostate biopsy was then performed and confirmed the diagnosis of primary lymphoma of the prostate. Results & Conclusion: This case highlights the importance of considering primary lymphoma of the prostate in patients presenting with macroscopic hematuria and an enlarged prostate, even if mp-MRI does not reveal any other abnormalities. Early diagnosis is crucial in such cases, as it allows for prompt initiation of treatment and may improve clinical outcomes. Given the rarity of this malignancy, clinicians must remain vigilant for its possible presentation and include it in the differential diagnosis when appropriate.
    VL  - 7
    IS  - 2
    ER  - 

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Author Information
  • Department of Urology, Bagcilar Training and Research Hospital, Istanbul, Turkey

  • Department of Radiology, University of Recep Tayyip Erdoğan, Rize, Turkey

  • Department of Pathology, Bagcilar Training and Research Hospital, Istanbul, Turkey

  • Department of Urology, BHT Clinic Istanbul TEMA Hospital, Istanbul, Turkey

  • Department of Urology, Bagcilar Training and Research Hospital, Istanbul, Turkey

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