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Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia

Received: 10 April 2022     Accepted: 25 April 2022     Published: 12 May 2022
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Abstract

Scabies is a skin disease caused by Sarcoptes scabiei infestation and is classified as a neglected tropical disease (NTD). Permethrin 5% is the first-line treatment for scabies. However, adherence and accuracy in topical creams are common problems. Thus, it is necessary to think of alternative medication that is more accessible, more straightforward, and lower the risk of resistance. Albendazole appears to be an alternative therapy for eradicating scabies in the community base. Sixty subjects diagnosed with scabies were recruited and divided into two groups with randomization. The first group was given 400 mg oral albendazole for three consecutive days on the first and second week. The second group was applied permethrin 5% to the whole body once on the first night of the first and second week. The evaluation was carried out for four weeks, and improvement was stated absence of new lesions and healing of old lesions and pruritus. Data were analyzed using SPSS software (version 25, SPSS Inc., Chicago., IL). The X2 test was used to examine the difference between groups, and p < 0.05 was considered significant. The cure rate of albendazole was significantly superior to permethrin topical (90.0% vs. 63.3%) with a p-value of 0.015. This study revealed the effectiveness of oral albendazole 400 mg/day for three consecutive days in the first and second weeks for treating scabies to topical permethrin 5%. No side effect seen in the use of albendazole and topical permethrin during the study. Albendazole could be an alternative drug option to eradicate scabies in low-middle-income countries.

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 8, Issue 3)
DOI 10.11648/j.ijcems.20220803.11
Page(s) 38-43
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Scabies, Permethrin 5%, Oral Albendazole

References
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[10] Meyersburg D, Kaiser A, Bauer JW. 2020. 'Loss of efficacy of topical 5% permethrin for treating scabies: an Austrian single-center study'. Journal of Dermatological Treatment: 1-4.
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Cite This Article
  • APA Style

    Fadhillah Ardiana Azmi, Yeniar Fitrianingrum, Ahmad Fiqri, Siti Ma’rufah, Moerbono Mochtar, et al. (2022). Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia. International Journal of Clinical and Experimental Medical Sciences, 8(3), 38-43. https://doi.org/10.11648/j.ijcems.20220803.11

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    ACS Style

    Fadhillah Ardiana Azmi; Yeniar Fitrianingrum; Ahmad Fiqri; Siti Ma’rufah; Moerbono Mochtar, et al. Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia. Int. J. Clin. Exp. Med. Sci. 2022, 8(3), 38-43. doi: 10.11648/j.ijcems.20220803.11

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    AMA Style

    Fadhillah Ardiana Azmi, Yeniar Fitrianingrum, Ahmad Fiqri, Siti Ma’rufah, Moerbono Mochtar, et al. Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia. Int J Clin Exp Med Sci. 2022;8(3):38-43. doi: 10.11648/j.ijcems.20220803.11

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  • @article{10.11648/j.ijcems.20220803.11,
      author = {Fadhillah Ardiana Azmi and Yeniar Fitrianingrum and Ahmad Fiqri and Siti Ma’rufah and Moerbono Mochtar and Suci Widhiati},
      title = {Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {8},
      number = {3},
      pages = {38-43},
      doi = {10.11648/j.ijcems.20220803.11},
      url = {https://doi.org/10.11648/j.ijcems.20220803.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20220803.11},
      abstract = {Scabies is a skin disease caused by Sarcoptes scabiei infestation and is classified as a neglected tropical disease (NTD). Permethrin 5% is the first-line treatment for scabies. However, adherence and accuracy in topical creams are common problems. Thus, it is necessary to think of alternative medication that is more accessible, more straightforward, and lower the risk of resistance. Albendazole appears to be an alternative therapy for eradicating scabies in the community base. Sixty subjects diagnosed with scabies were recruited and divided into two groups with randomization. The first group was given 400 mg oral albendazole for three consecutive days on the first and second week. The second group was applied permethrin 5% to the whole body once on the first night of the first and second week. The evaluation was carried out for four weeks, and improvement was stated absence of new lesions and healing of old lesions and pruritus. Data were analyzed using SPSS software (version 25, SPSS Inc., Chicago., IL). The X2 test was used to examine the difference between groups, and p < 0.05 was considered significant. The cure rate of albendazole was significantly superior to permethrin topical (90.0% vs. 63.3%) with a p-value of 0.015. This study revealed the effectiveness of oral albendazole 400 mg/day for three consecutive days in the first and second weeks for treating scabies to topical permethrin 5%. No side effect seen in the use of albendazole and topical permethrin during the study. Albendazole could be an alternative drug option to eradicate scabies in low-middle-income countries.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia
    AU  - Fadhillah Ardiana Azmi
    AU  - Yeniar Fitrianingrum
    AU  - Ahmad Fiqri
    AU  - Siti Ma’rufah
    AU  - Moerbono Mochtar
    AU  - Suci Widhiati
    Y1  - 2022/05/12
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ijcems.20220803.11
    DO  - 10.11648/j.ijcems.20220803.11
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 38
    EP  - 43
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20220803.11
    AB  - Scabies is a skin disease caused by Sarcoptes scabiei infestation and is classified as a neglected tropical disease (NTD). Permethrin 5% is the first-line treatment for scabies. However, adherence and accuracy in topical creams are common problems. Thus, it is necessary to think of alternative medication that is more accessible, more straightforward, and lower the risk of resistance. Albendazole appears to be an alternative therapy for eradicating scabies in the community base. Sixty subjects diagnosed with scabies were recruited and divided into two groups with randomization. The first group was given 400 mg oral albendazole for three consecutive days on the first and second week. The second group was applied permethrin 5% to the whole body once on the first night of the first and second week. The evaluation was carried out for four weeks, and improvement was stated absence of new lesions and healing of old lesions and pruritus. Data were analyzed using SPSS software (version 25, SPSS Inc., Chicago., IL). The X2 test was used to examine the difference between groups, and p < 0.05 was considered significant. The cure rate of albendazole was significantly superior to permethrin topical (90.0% vs. 63.3%) with a p-value of 0.015. This study revealed the effectiveness of oral albendazole 400 mg/day for three consecutive days in the first and second weeks for treating scabies to topical permethrin 5%. No side effect seen in the use of albendazole and topical permethrin during the study. Albendazole could be an alternative drug option to eradicate scabies in low-middle-income countries.
    VL  - 8
    IS  - 3
    ER  - 

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Author Information
  • Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

  • Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

  • Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

  • Department of Pharmacology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

  • Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

  • Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

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