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Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins

Received: 3 August 2021     Accepted: 13 September 2021     Published: 28 October 2021
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Abstract

Acute coronary syndrome (ACS) is the leading cause of mortality worldwide comprised with ST-segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI). A cross sectional study for a period from March 2015 to June 2016 was designed to find out the role of resistin in endothelium dysfunction in STEMI and NSTEMI patients and its correlation with cardiac markers troponins. 100 consented patients with diagnosed STEMI and NSTEMI with age range 40 to 70 years were included in the study. 50 age matched healthy subjects were taken as controls. Base line blood tests fasting blood sugar, blood urea, serum creatinine, serum total cholesterol and serum triglyceride were estimated by auto analyzer using standard kits. Special tests including serum resistin, cardiac troponin T and cardiac troponin I were estimated by the technique of ELISA. Results were analyzed by SPSS 20 and found that the base line parameters except serum creatinine were significantly raised in patients as compare to controls. Level of resistin and cardiac biomarkers cardiac troponin T (cTnT) and cardiac troponin I (cTnI) were significantly raised in STEMI patients as compared to NSTEMI patients. A significant positive correlation of resistin with cardiac troponin T and I was observed in STEMI patients only. It is therefore concluded that increased level of resistin along with cardiac markers may be presented as a predictor of injury of myocardium and in turn indicate the severity of AMI in STEMI patients.

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 7, Issue 5)
DOI 10.11648/j.ijcems.20210705.14
Page(s) 152-159
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

STEMI, NSTEMI, Resistin, Cardiac Troponin T, Cardiac Troponin I

References
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Cite This Article
  • APA Style

    Shazia Rashid, Javed Anver Qureshi, Rukhshan Khurshid, Huma Ashraf, Saima Rasheed, et al. (2021). Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins. International Journal of Clinical and Experimental Medical Sciences, 7(5), 152-159. https://doi.org/10.11648/j.ijcems.20210705.14

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    ACS Style

    Shazia Rashid; Javed Anver Qureshi; Rukhshan Khurshid; Huma Ashraf; Saima Rasheed, et al. Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins. Int. J. Clin. Exp. Med. Sci. 2021, 7(5), 152-159. doi: 10.11648/j.ijcems.20210705.14

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    AMA Style

    Shazia Rashid, Javed Anver Qureshi, Rukhshan Khurshid, Huma Ashraf, Saima Rasheed, et al. Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins. Int J Clin Exp Med Sci. 2021;7(5):152-159. doi: 10.11648/j.ijcems.20210705.14

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  • @article{10.11648/j.ijcems.20210705.14,
      author = {Shazia Rashid and Javed Anver Qureshi and Rukhshan Khurshid and Huma Ashraf and Saima Rasheed and Uzma Faryal},
      title = {Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {7},
      number = {5},
      pages = {152-159},
      doi = {10.11648/j.ijcems.20210705.14},
      url = {https://doi.org/10.11648/j.ijcems.20210705.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20210705.14},
      abstract = {Acute coronary syndrome (ACS) is the leading cause of mortality worldwide comprised with ST-segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI). A cross sectional study for a period from March 2015 to June 2016 was designed to find out the role of resistin in endothelium dysfunction in STEMI and NSTEMI patients and its correlation with cardiac markers troponins. 100 consented patients with diagnosed STEMI and NSTEMI with age range 40 to 70 years were included in the study. 50 age matched healthy subjects were taken as controls. Base line blood tests fasting blood sugar, blood urea, serum creatinine, serum total cholesterol and serum triglyceride were estimated by auto analyzer using standard kits. Special tests including serum resistin, cardiac troponin T and cardiac troponin I were estimated by the technique of ELISA. Results were analyzed by SPSS 20 and found that the base line parameters except serum creatinine were significantly raised in patients as compare to controls. Level of resistin and cardiac biomarkers cardiac troponin T (cTnT) and cardiac troponin I (cTnI) were significantly raised in STEMI patients as compared to NSTEMI patients. A significant positive correlation of resistin with cardiac troponin T and I was observed in STEMI patients only. It is therefore concluded that increased level of resistin along with cardiac markers may be presented as a predictor of injury of myocardium and in turn indicate the severity of AMI in STEMI patients.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins
    AU  - Shazia Rashid
    AU  - Javed Anver Qureshi
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    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
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    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20210705.14
    AB  - Acute coronary syndrome (ACS) is the leading cause of mortality worldwide comprised with ST-segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI). A cross sectional study for a period from March 2015 to June 2016 was designed to find out the role of resistin in endothelium dysfunction in STEMI and NSTEMI patients and its correlation with cardiac markers troponins. 100 consented patients with diagnosed STEMI and NSTEMI with age range 40 to 70 years were included in the study. 50 age matched healthy subjects were taken as controls. Base line blood tests fasting blood sugar, blood urea, serum creatinine, serum total cholesterol and serum triglyceride were estimated by auto analyzer using standard kits. Special tests including serum resistin, cardiac troponin T and cardiac troponin I were estimated by the technique of ELISA. Results were analyzed by SPSS 20 and found that the base line parameters except serum creatinine were significantly raised in patients as compare to controls. Level of resistin and cardiac biomarkers cardiac troponin T (cTnT) and cardiac troponin I (cTnI) were significantly raised in STEMI patients as compared to NSTEMI patients. A significant positive correlation of resistin with cardiac troponin T and I was observed in STEMI patients only. It is therefore concluded that increased level of resistin along with cardiac markers may be presented as a predictor of injury of myocardium and in turn indicate the severity of AMI in STEMI patients.
    VL  - 7
    IS  - 5
    ER  - 

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Author Information
  • Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan

  • Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan

  • Department of Biochemistry, Shalamar Medical and Dental College, Lahore, Pakistan

  • Department of Biochemistry, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan

  • Department of Biochemistry, Niazi Medical and Dental College, Sargodha, Pakistan

  • Department of Biochemistry, Women Medical College, Abbottabad, Pakistan

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