Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon

Mbongue-Mikangue Chris Andre; Sake Stephanie Carole; Njiki-Bikoe Jacky; Riwom Essama Sara Honorine

doi:doi:10.11648/j.ijbecs.20241002.11

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Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon

Mbongue-Mikangue Chris Andre^*

, Sake Stephanie Carole

, Njiki-Bikoe Jacky

, Riwom Essama Sara Honorine

Published in International Journal of Biomedical Engineering and Clinical Science (Volume 10, Issue 2)

Received: 26 May 2024 Accepted: 26 June 2024 Published: 23 December 2024

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Abstract

Background and justification: Infection with the hepatitis B virus is a major public health problem; However, Asia and sub-Saharan Africa are the most affected by it. The status of hepatitis B virus in pregnant women is essential for the effective management of the disease and the prevention of mother to child transmission. The objective of this study is to determine the prevalence of HBV markers and risk factors associated with infection in pregnant women at the Yaounde University Teaching Hospital (YUTH). Methodology: A prospective, cross multicenter study was conducted from 17 September 2018 to 25 February 2019 in 102 pregnant women aged 15 to 44 years. After obtaining ethical clearance, obstetric and sociodemographic risk factors were collected; samples were also taken and analyzed by the immuno-chromatographic method for the detection of HBsAg, for anti-HBs, HBeAg, anti-HBeAc and the anti-HBc antibodies. Statistical analysis was performed by Microsoft Excel 2016; SPSS Version 22. A P value < 0.05 was considered statistically significant. Results: Of the 102 pregnant women, 10.78% (11/64) tested positive for HBsAg; 15.68% (16/64) had developed anti-HBs, and 26.47% (27/64) had previous contact with HBV. The highest prevalence of HBsAg was recorded in the age group 25-35 years (11.76%, P = 0.95). Similarly, the single status (P = 0.001) scarification (P = 0.00) and tattooing (P = 0.00008) were significantly associated with HBV infection and previous contact with HBV. Scarification and tattooing were significantly associated with a probable chronic hepatitis profile4 (P = 0.00009) and the inactive carrier HBsAg profile3 (P = 0.0002). Conclusion: The HBV infection is high among pregnant women at the YUTH (10.78%), especially among single pregnant women. Scarification, tattooing and no knowledge of the disease are factors significantly associated with HBV carriages (p <0.05). It is therefore necessary to introduce routine in prenatal assessment of pregnant women routine screening for HBV markers and possibly a vaccination to prevent vertical transmission (mother to child).

Published in	International Journal of Biomedical Engineering and Clinical Science (Volume 10, Issue 2)
DOI	10.11648/j.ijbecs.20241002.11
Page(s)	18-29
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pregnancy, Viral Hepatitis B, Risk Factors, YUTH

References

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APA Style

Andre, M. C., Carole, S. S., Jacky, N., Honorine, R. E. S. (2024). Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon. International Journal of Biomedical Engineering and Clinical Science, 10(2), 18-29. https://doi.org/10.11648/j.ijbecs.20241002.11

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ACS Style

Andre, M. C.; Carole, S. S.; Jacky, N.; Honorine, R. E. S. Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon. Int. J. Biomed. Eng. Clin. Sci. 2024, 10(2), 18-29. doi: 10.11648/j.ijbecs.20241002.11

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AMA Style

Andre MC, Carole SS, Jacky N, Honorine RES. Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon. Int J Biomed Eng Clin Sci. 2024;10(2):18-29. doi: 10.11648/j.ijbecs.20241002.11

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@article{10.11648/j.ijbecs.20241002.11,
  author = {Mbongue-Mikangue Chris Andre and Sake Stephanie Carole and Njiki-Bikoe Jacky and Riwom Essama Sara Honorine},
  title = {Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon
},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {10},
  number = {2},
  pages = {18-29},
  doi = {10.11648/j.ijbecs.20241002.11},
  url = {https://doi.org/10.11648/j.ijbecs.20241002.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20241002.11},
  abstract = {Background and justification: Infection with the hepatitis B virus is a major public health problem; However, Asia and sub-Saharan Africa are the most affected by it. The status of hepatitis B virus in pregnant women is essential for the effective management of the disease and the prevention of mother to child transmission. The objective of this study is to determine the prevalence of HBV markers and risk factors associated with infection in pregnant women at the Yaounde University Teaching Hospital (YUTH). Methodology: A prospective, cross multicenter study was conducted from 17 September 2018 to 25 February 2019 in 102 pregnant women aged 15 to 44 years. After obtaining ethical clearance, obstetric and sociodemographic risk factors were collected; samples were also taken and analyzed by the immuno-chromatographic method for the detection of HBsAg, for anti-HBs, HBeAg, anti-HBeAc and the anti-HBc antibodies. Statistical analysis was performed by Microsoft Excel 2016; SPSS Version 22. A P value Results: Of the 102 pregnant women, 10.78% (11/64) tested positive for HBsAg; 15.68% (16/64) had developed anti-HBs, and 26.47% (27/64) had previous contact with HBV. The highest prevalence of HBsAg was recorded in the age group 25-35 years (11.76%, P = 0.95). Similarly, the single status (P = 0.001) scarification (P = 0.00) and tattooing (P = 0.00008) were significantly associated with HBV infection and previous contact with HBV. Scarification and tattooing were significantly associated with a probable chronic hepatitis profile4 (P = 0.00009) and the inactive carrier HBsAg profile3 (P = 0.0002). Conclusion: The HBV infection is high among pregnant women at the YUTH (10.78%), especially among single pregnant women. Scarification, tattooing and no knowledge of the disease are factors significantly associated with HBV carriages (p <0.05). It is therefore necessary to introduce routine in prenatal assessment of pregnant women routine screening for HBV markers and possibly a vaccination to prevent vertical transmission (mother to child).
},
 year = {2024}
}

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TY  - JOUR
T1  - Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon

AU  - Mbongue-Mikangue Chris Andre
AU  - Sake Stephanie Carole
AU  - Njiki-Bikoe Jacky
AU  - Riwom Essama Sara Honorine
Y1  - 2024/12/23
PY  - 2024
N1  - https://doi.org/10.11648/j.ijbecs.20241002.11
DO  - 10.11648/j.ijbecs.20241002.11
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 18
EP  - 29
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20241002.11
AB  - Background and justification: Infection with the hepatitis B virus is a major public health problem; However, Asia and sub-Saharan Africa are the most affected by it. The status of hepatitis B virus in pregnant women is essential for the effective management of the disease and the prevention of mother to child transmission. The objective of this study is to determine the prevalence of HBV markers and risk factors associated with infection in pregnant women at the Yaounde University Teaching Hospital (YUTH). Methodology: A prospective, cross multicenter study was conducted from 17 September 2018 to 25 February 2019 in 102 pregnant women aged 15 to 44 years. After obtaining ethical clearance, obstetric and sociodemographic risk factors were collected; samples were also taken and analyzed by the immuno-chromatographic method for the detection of HBsAg, for anti-HBs, HBeAg, anti-HBeAc and the anti-HBc antibodies. Statistical analysis was performed by Microsoft Excel 2016; SPSS Version 22. A P value Results: Of the 102 pregnant women, 10.78% (11/64) tested positive for HBsAg; 15.68% (16/64) had developed anti-HBs, and 26.47% (27/64) had previous contact with HBV. The highest prevalence of HBsAg was recorded in the age group 25-35 years (11.76%, P = 0.95). Similarly, the single status (P = 0.001) scarification (P = 0.00) and tattooing (P = 0.00008) were significantly associated with HBV infection and previous contact with HBV. Scarification and tattooing were significantly associated with a probable chronic hepatitis profile4 (P = 0.00009) and the inactive carrier HBsAg profile3 (P = 0.0002). Conclusion: The HBV infection is high among pregnant women at the YUTH (10.78%), especially among single pregnant women. Scarification, tattooing and no knowledge of the disease are factors significantly associated with HBV carriages (p <0.05). It is therefore necessary to introduce routine in prenatal assessment of pregnant women routine screening for HBV markers and possibly a vaccination to prevent vertical transmission (mother to child).

VL  - 10
IS  - 2
ER  -

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Author Information

Mbongue-Mikangue Chris Andre

Department of Microbiology, University of Yaoundé 1, Yaounde, Cameroon

Contact Email

http://orcid.org/0000-0001-9131-6438
Sake Stephanie Carole

Department of Microbiology, University of Yaoundé 1, Yaounde, Cameroon

Contact Email

http://orcid.org/0000-0003-1219-2137
Njiki-Bikoe Jacky

Department of Microbiology, University of Yaoundé 1, Yaounde, Cameroon

Contact Email

http://orcid.org/0000-0002-6677-1452
Riwom Essama Sara Honorine

Department of Microbiology, University of Yaoundé 1, Yaounde, Cameroon

Contact Email

http://orcid.org/0000-0001-5090-4612

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APA Style

Andre, M. C., Carole, S. S., Jacky, N., Honorine, R. E. S. (2024). Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon. International Journal of Biomedical Engineering and Clinical Science, 10(2), 18-29. https://doi.org/10.11648/j.ijbecs.20241002.11

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ACS Style

Andre, M. C.; Carole, S. S.; Jacky, N.; Honorine, R. E. S. Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon. Int. J. Biomed. Eng. Clin. Sci. 2024, 10(2), 18-29. doi: 10.11648/j.ijbecs.20241002.11

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AMA Style

Andre MC, Carole SS, Jacky N, Honorine RES. Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon. Int J Biomed Eng Clin Sci. 2024;10(2):18-29. doi: 10.11648/j.ijbecs.20241002.11

Copy | Download

@article{10.11648/j.ijbecs.20241002.11,
  author = {Mbongue-Mikangue Chris Andre and Sake Stephanie Carole and Njiki-Bikoe Jacky and Riwom Essama Sara Honorine},
  title = {Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon
},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {10},
  number = {2},
  pages = {18-29},
  doi = {10.11648/j.ijbecs.20241002.11},
  url = {https://doi.org/10.11648/j.ijbecs.20241002.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20241002.11},
  abstract = {Background and justification: Infection with the hepatitis B virus is a major public health problem; However, Asia and sub-Saharan Africa are the most affected by it. The status of hepatitis B virus in pregnant women is essential for the effective management of the disease and the prevention of mother to child transmission. The objective of this study is to determine the prevalence of HBV markers and risk factors associated with infection in pregnant women at the Yaounde University Teaching Hospital (YUTH). Methodology: A prospective, cross multicenter study was conducted from 17 September 2018 to 25 February 2019 in 102 pregnant women aged 15 to 44 years. After obtaining ethical clearance, obstetric and sociodemographic risk factors were collected; samples were also taken and analyzed by the immuno-chromatographic method for the detection of HBsAg, for anti-HBs, HBeAg, anti-HBeAc and the anti-HBc antibodies. Statistical analysis was performed by Microsoft Excel 2016; SPSS Version 22. A P value Results: Of the 102 pregnant women, 10.78% (11/64) tested positive for HBsAg; 15.68% (16/64) had developed anti-HBs, and 26.47% (27/64) had previous contact with HBV. The highest prevalence of HBsAg was recorded in the age group 25-35 years (11.76%, P = 0.95). Similarly, the single status (P = 0.001) scarification (P = 0.00) and tattooing (P = 0.00008) were significantly associated with HBV infection and previous contact with HBV. Scarification and tattooing were significantly associated with a probable chronic hepatitis profile4 (P = 0.00009) and the inactive carrier HBsAg profile3 (P = 0.0002). Conclusion: The HBV infection is high among pregnant women at the YUTH (10.78%), especially among single pregnant women. Scarification, tattooing and no knowledge of the disease are factors significantly associated with HBV carriages (p <0.05). It is therefore necessary to introduce routine in prenatal assessment of pregnant women routine screening for HBV markers and possibly a vaccination to prevent vertical transmission (mother to child).
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Seroprevalence of Hepatitis B Virus in Pregnant Women and Associated Risk Factors, Monitored at the Yaounde University Teaching Hospital, Cameroon

AU  - Mbongue-Mikangue Chris Andre
AU  - Sake Stephanie Carole
AU  - Njiki-Bikoe Jacky
AU  - Riwom Essama Sara Honorine
Y1  - 2024/12/23
PY  - 2024
N1  - https://doi.org/10.11648/j.ijbecs.20241002.11
DO  - 10.11648/j.ijbecs.20241002.11
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 18
EP  - 29
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20241002.11
AB  - Background and justification: Infection with the hepatitis B virus is a major public health problem; However, Asia and sub-Saharan Africa are the most affected by it. The status of hepatitis B virus in pregnant women is essential for the effective management of the disease and the prevention of mother to child transmission. The objective of this study is to determine the prevalence of HBV markers and risk factors associated with infection in pregnant women at the Yaounde University Teaching Hospital (YUTH). Methodology: A prospective, cross multicenter study was conducted from 17 September 2018 to 25 February 2019 in 102 pregnant women aged 15 to 44 years. After obtaining ethical clearance, obstetric and sociodemographic risk factors were collected; samples were also taken and analyzed by the immuno-chromatographic method for the detection of HBsAg, for anti-HBs, HBeAg, anti-HBeAc and the anti-HBc antibodies. Statistical analysis was performed by Microsoft Excel 2016; SPSS Version 22. A P value Results: Of the 102 pregnant women, 10.78% (11/64) tested positive for HBsAg; 15.68% (16/64) had developed anti-HBs, and 26.47% (27/64) had previous contact with HBV. The highest prevalence of HBsAg was recorded in the age group 25-35 years (11.76%, P = 0.95). Similarly, the single status (P = 0.001) scarification (P = 0.00) and tattooing (P = 0.00008) were significantly associated with HBV infection and previous contact with HBV. Scarification and tattooing were significantly associated with a probable chronic hepatitis profile4 (P = 0.00009) and the inactive carrier HBsAg profile3 (P = 0.0002). Conclusion: The HBV infection is high among pregnant women at the YUTH (10.78%), especially among single pregnant women. Scarification, tattooing and no knowledge of the disease are factors significantly associated with HBV carriages (p <0.05). It is therefore necessary to introduce routine in prenatal assessment of pregnant women routine screening for HBV markers and possibly a vaccination to prevent vertical transmission (mother to child).

VL  - 10
IS  - 2
ER  -

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