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Homocysteine as a Predictor of Hypertensive Disorders of Pregnancy

Received: 30 November 2021     Accepted: 11 January 2022     Published: 14 April 2022
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Abstract

Homocysteine is an amino acid that is a product of methionine metabolism, it is related to preeclampsia in 20-30%, the increase of this or hyperhomocysteinemia may result from the genetic defect of the enzyme methylenetetrahydrofolate reductase involved in the synthesis of homocysteine. Maternal mortality due to preeclampsia is up to 44% and perinatal mortality is reported at up to 27.8%. The objective of this research was to determine homocysteine levels as a predictor of preeclampsia in pregnant women that have 12 to 20 weeks. This was an observational, longitudinal and prospective investigation. The study population were patients attending the first prenatal care consultation between the 12th to 20th weeks, the sample was random and it included 360 patients from whom it was determined their serum homocysteine level. The study excluded 48 patients who did not meet the inclusion and exclusion criteria; it was found homogeneity among the patients, 270 patients (86.5%) had a normal evolution at pregnancy, 27 patients (8.65%) had gestational hypertension, 9 (2.88%) mild preeclampsia and 6 patients (1.9%) severe preeclampsia, none developed HELLP syndrome. Increased homocysteine levels were found in 9 patients who were not related to hypertensive pregnancy disorders. In the present research, homocysteine was not shown to be a predictor of hypertensive disease in pregnancy.

Published in International Journal of Biomedical Engineering and Clinical Science (Volume 8, Issue 1)
DOI 10.11648/j.ijbecs.20220801.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Homocysteine, Pre-eclampsia, Gestational Hypertension, Hypertensive Gestosis

References
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Cite This Article
  • APA Style

    Ramon Vargas-Vera, Martha Placencia-Ibadango, Kalid Vargas-Silva, Noren Villalobos Inciarte, Daniela Zalamea-Holguin, et al. (2022). Homocysteine as a Predictor of Hypertensive Disorders of Pregnancy. International Journal of Biomedical Engineering and Clinical Science, 8(1), 1-7. https://doi.org/10.11648/j.ijbecs.20220801.11

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    ACS Style

    Ramon Vargas-Vera; Martha Placencia-Ibadango; Kalid Vargas-Silva; Noren Villalobos Inciarte; Daniela Zalamea-Holguin, et al. Homocysteine as a Predictor of Hypertensive Disorders of Pregnancy. Int. J. Biomed. Eng. Clin. Sci. 2022, 8(1), 1-7. doi: 10.11648/j.ijbecs.20220801.11

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    AMA Style

    Ramon Vargas-Vera, Martha Placencia-Ibadango, Kalid Vargas-Silva, Noren Villalobos Inciarte, Daniela Zalamea-Holguin, et al. Homocysteine as a Predictor of Hypertensive Disorders of Pregnancy. Int J Biomed Eng Clin Sci. 2022;8(1):1-7. doi: 10.11648/j.ijbecs.20220801.11

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  • @article{10.11648/j.ijbecs.20220801.11,
      author = {Ramon Vargas-Vera and Martha Placencia-Ibadango and Kalid Vargas-Silva and Noren Villalobos Inciarte and Daniela Zalamea-Holguin and Saul Alencastro-Placencia and Eneida Encalada-Moreira},
      title = {Homocysteine as a Predictor of Hypertensive Disorders of Pregnancy},
      journal = {International Journal of Biomedical Engineering and Clinical Science},
      volume = {8},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.ijbecs.20220801.11},
      url = {https://doi.org/10.11648/j.ijbecs.20220801.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20220801.11},
      abstract = {Homocysteine is an amino acid that is a product of methionine metabolism, it is related to preeclampsia in 20-30%, the increase of this or hyperhomocysteinemia may result from the genetic defect of the enzyme methylenetetrahydrofolate reductase involved in the synthesis of homocysteine. Maternal mortality due to preeclampsia is up to 44% and perinatal mortality is reported at up to 27.8%. The objective of this research was to determine homocysteine levels as a predictor of preeclampsia in pregnant women that have 12 to 20 weeks. This was an observational, longitudinal and prospective investigation. The study population were patients attending the first prenatal care consultation between the 12th to 20th weeks, the sample was random and it included 360 patients from whom it was determined their serum homocysteine level. The study excluded 48 patients who did not meet the inclusion and exclusion criteria; it was found homogeneity among the patients, 270 patients (86.5%) had a normal evolution at pregnancy, 27 patients (8.65%) had gestational hypertension, 9 (2.88%) mild preeclampsia and 6 patients (1.9%) severe preeclampsia, none developed HELLP syndrome. Increased homocysteine levels were found in 9 patients who were not related to hypertensive pregnancy disorders. In the present research, homocysteine was not shown to be a predictor of hypertensive disease in pregnancy.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Homocysteine as a Predictor of Hypertensive Disorders of Pregnancy
    AU  - Ramon Vargas-Vera
    AU  - Martha Placencia-Ibadango
    AU  - Kalid Vargas-Silva
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    JF  - International Journal of Biomedical Engineering and Clinical Science
    JO  - International Journal of Biomedical Engineering and Clinical Science
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    PB  - Science Publishing Group
    SN  - 2472-1301
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    AB  - Homocysteine is an amino acid that is a product of methionine metabolism, it is related to preeclampsia in 20-30%, the increase of this or hyperhomocysteinemia may result from the genetic defect of the enzyme methylenetetrahydrofolate reductase involved in the synthesis of homocysteine. Maternal mortality due to preeclampsia is up to 44% and perinatal mortality is reported at up to 27.8%. The objective of this research was to determine homocysteine levels as a predictor of preeclampsia in pregnant women that have 12 to 20 weeks. This was an observational, longitudinal and prospective investigation. The study population were patients attending the first prenatal care consultation between the 12th to 20th weeks, the sample was random and it included 360 patients from whom it was determined their serum homocysteine level. The study excluded 48 patients who did not meet the inclusion and exclusion criteria; it was found homogeneity among the patients, 270 patients (86.5%) had a normal evolution at pregnancy, 27 patients (8.65%) had gestational hypertension, 9 (2.88%) mild preeclampsia and 6 patients (1.9%) severe preeclampsia, none developed HELLP syndrome. Increased homocysteine levels were found in 9 patients who were not related to hypertensive pregnancy disorders. In the present research, homocysteine was not shown to be a predictor of hypertensive disease in pregnancy.
    VL  - 8
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Author Information
  • School Career of Medicine, University of Guayaquil, Guayaquil, Ecuador

  • Center for Genetic and Perinatal Studies, Cepegen, Guayaquil, Ecuador

  • Center for Genetic and Perinatal Studies, Cepegen, Guayaquil, Ecuador

  • Graduate School, University of Zulia, Maracaibo, Venezuela

  • School Career of Medicine, University of Guayaquil, Guayaquil, Ecuador

  • School of Medicine, Santiago de Guayaquil Catholic University, Guayaquil, Ecuador

  • School of Medicine, Santiago de Guayaquil Catholic University, Guayaquil, Ecuador

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