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The Role of Lama2 in Cancer: Current Perspectives

Received: 26 August 2022     Accepted: 7 September 2022     Published: 29 November 2022
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Abstract

Laminin is a large molecular glycoprotein heterotrimer assembled from different α, β, and γ chains. In 1979, Non-collagen glycoprotein were isolated from basement membrane-rich tumors and cells that produce basement membranes and purified into laminin. The LAMA2 gene encodes the subunit of Laminin α2 and is located on chromosome 6q22-q33. Recently, new evidence has emerged that LAMA2 is involved in the biological processes of extracellular matrix (ECM) tissue and adhesions, and is related to inflammatory breast cancer (IBC), pituitary adenoma (PitNET), ovarian cancer (OC), Laryngopharyngeal squamous cell carcinoma (L/P-SCC) and many other diseases. In addition, the role of LAMA2 gene in mutation, differential expression and in terms of signal pathways in many cancers and other diseases, as well as promoter DNA methylation, all show the important regulatory role of LAMA2 in molecular biological mechanisms. The review briefly generalizes the progress in deciphering this unique molecule in recent years, including molecular structure of Lama2 gene, Lama2 gene regulation and DNA methylation, Lama2 and its protein binding partners, clinical relevance of Lama2, prospective application in diagnosis and potential therapeutic application of Lama2, and summarizes the new frontiers of Lama2 research and predicts the new prospects of Lama2 as a diagnostic and prognostic indicator of cancer and other diseases.

Published in Cancer Research Journal (Volume 10, Issue 4)
DOI 10.11648/j.crj.20221004.13
Page(s) 85-88
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Lama2, Laminin, Gene, Gene Regulation, Epigenetic, Cancer

References
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Cite This Article
  • APA Style

    Jiamei Hu, Shaoying Li. (2022). The Role of Lama2 in Cancer: Current Perspectives. Cancer Research Journal, 10(4), 85-88. https://doi.org/10.11648/j.crj.20221004.13

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    ACS Style

    Jiamei Hu; Shaoying Li. The Role of Lama2 in Cancer: Current Perspectives. Cancer Res. J. 2022, 10(4), 85-88. doi: 10.11648/j.crj.20221004.13

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    AMA Style

    Jiamei Hu, Shaoying Li. The Role of Lama2 in Cancer: Current Perspectives. Cancer Res J. 2022;10(4):85-88. doi: 10.11648/j.crj.20221004.13

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  • @article{10.11648/j.crj.20221004.13,
      author = {Jiamei Hu and Shaoying Li},
      title = {The Role of Lama2 in Cancer: Current Perspectives},
      journal = {Cancer Research Journal},
      volume = {10},
      number = {4},
      pages = {85-88},
      doi = {10.11648/j.crj.20221004.13},
      url = {https://doi.org/10.11648/j.crj.20221004.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221004.13},
      abstract = {Laminin is a large molecular glycoprotein heterotrimer assembled from different α, β, and γ chains. In 1979, Non-collagen glycoprotein were isolated from basement membrane-rich tumors and cells that produce basement membranes and purified into laminin. The LAMA2 gene encodes the subunit of Laminin α2 and is located on chromosome 6q22-q33. Recently, new evidence has emerged that LAMA2 is involved in the biological processes of extracellular matrix (ECM) tissue and adhesions, and is related to inflammatory breast cancer (IBC), pituitary adenoma (PitNET), ovarian cancer (OC), Laryngopharyngeal squamous cell carcinoma (L/P-SCC) and many other diseases. In addition, the role of LAMA2 gene in mutation, differential expression and in terms of signal pathways in many cancers and other diseases, as well as promoter DNA methylation, all show the important regulatory role of LAMA2 in molecular biological mechanisms. The review briefly generalizes the progress in deciphering this unique molecule in recent years, including molecular structure of Lama2 gene, Lama2 gene regulation and DNA methylation, Lama2 and its protein binding partners, clinical relevance of Lama2, prospective application in diagnosis and potential therapeutic application of Lama2, and summarizes the new frontiers of Lama2 research and predicts the new prospects of Lama2 as a diagnostic and prognostic indicator of cancer and other diseases.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - The Role of Lama2 in Cancer: Current Perspectives
    AU  - Jiamei Hu
    AU  - Shaoying Li
    Y1  - 2022/11/29
    PY  - 2022
    N1  - https://doi.org/10.11648/j.crj.20221004.13
    DO  - 10.11648/j.crj.20221004.13
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 85
    EP  - 88
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20221004.13
    AB  - Laminin is a large molecular glycoprotein heterotrimer assembled from different α, β, and γ chains. In 1979, Non-collagen glycoprotein were isolated from basement membrane-rich tumors and cells that produce basement membranes and purified into laminin. The LAMA2 gene encodes the subunit of Laminin α2 and is located on chromosome 6q22-q33. Recently, new evidence has emerged that LAMA2 is involved in the biological processes of extracellular matrix (ECM) tissue and adhesions, and is related to inflammatory breast cancer (IBC), pituitary adenoma (PitNET), ovarian cancer (OC), Laryngopharyngeal squamous cell carcinoma (L/P-SCC) and many other diseases. In addition, the role of LAMA2 gene in mutation, differential expression and in terms of signal pathways in many cancers and other diseases, as well as promoter DNA methylation, all show the important regulatory role of LAMA2 in molecular biological mechanisms. The review briefly generalizes the progress in deciphering this unique molecule in recent years, including molecular structure of Lama2 gene, Lama2 gene regulation and DNA methylation, Lama2 and its protein binding partners, clinical relevance of Lama2, prospective application in diagnosis and potential therapeutic application of Lama2, and summarizes the new frontiers of Lama2 research and predicts the new prospects of Lama2 as a diagnostic and prognostic indicator of cancer and other diseases.
    VL  - 10
    IS  - 4
    ER  - 

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Author Information
  • Department of Thyroid and Breast Surgery, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Sanming Project of Medicine in Shenzhen, Shenzhen, P. R. China

  • Department of Thyroid and Breast Surgery, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Sanming Project of Medicine in Shenzhen, Shenzhen, P. R. China

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