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Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer

Received: 28 March 2022     Accepted: 15 April 2022     Published: 25 April 2022
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Abstract

Breast cancer ranks as the number one cancer among Indian females with survival as low as 66.1%. Relationship between cholesterol and breast cancer has triggered special interest due to their role in important cellular processes that steer toward carcinogenesis. The interplay between cholesterol and tumor development have been studied in experimental breast cancer models. However, epidemiological data reveal conflicting results, that need to be integrated and put into appropriate viewpoint. This study aims to investigate and corroborate the impact of total cholesterol (TC), triglyceride (TG), VLDL, LDL and HDL cholesterol on the disease-free and overall survival of patients with breast cancer. This study retrospectively analyzed 50 breast cancer patients who underwent radical surgery and attended follow-up visits at KIMS Hospitals. The blood lipid levels such as TC, TG, VLDL, LDL and HDL cholesterol were collected and analyzed from the database of Department of Laboratory Medicine. Potential prognostic factors including age, menopause, grade, receptor status, systemic cholesterol profile etc., were analyzed by univariate and multivariate analysis. TC less than 180mg/dL was associated with disease relapse in univariate analysis. TG, VLDL, LDL and HDL cholesterol were not significantly correlated either to disease-free or overall survival. Low systemic cholesterol level could be a significant prognostic factor for a shorter disease-free survival.

Published in Cancer Research Journal (Volume 10, Issue 2)
DOI 10.11648/j.crj.20221002.12
Page(s) 30-33
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Carcinogenesis, Lipoprotein, Cholesterol, Prognosis, Survival

References
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[2] Garcia-Estevez L, Moreno-Bueno G. Updating the role of obesity and cholesterol in breast cancer, Br Can Res 2019; 21: 35.
[3] Long J, Zhang CJ, Zhu N, et al. Lipid metabolism and carcinogenesis, cancer development, Am J Cancer Res 2018; 8: 778-791.
[4] Santos CR, Domingues G, Matias I et al. LDL-cholesterol signalling induces breast cancer proliferation and invasion. Lipids Health Dis 2014; 13: 16.
[5] Gallagher EJ, Zelenko Z, Neel BA, Antoniou IM, Rajan L, Kase N, LeRoith D. Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia, Oncogene 2017; 36: 6462-6471.
[6] Feng H, Wang M, Wu C, et al. High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in lung adenocarcinoma: A STROBE compliant article, Medicine (Baltimore) 2018; 97: e0203.
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[8] Llaverias G, Danilo C, Mercier I, et al. Role of cholesterol in the development and progression of breast cancer, Am J Pathol 2011; 178: 402-412.
[9] Yadav NK, Poudel B, Thanpari C, Chandra Koner B. Assessment of biochemical profiles in premenopausal and postmenopausal women with breast cancer. Asian Paci J Cancer Prev 2012; 13: 3385–3388.
[10] Ni H, Liu H, Gao R. Serum Lipids and Breast Cancer Risk: A Meta-Analysis of Prospective Cohort Studies. PLoS ONE 2015; 10: e0142669.
[11] Ha M, Sung J, Song YM. Serum t and the risk of breast cancer in postmenopausal Korean women. Cancer Causes Control 2009; 20: 1055–1060.
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[13] Kim Y, Park SK, Han W, et al. Serum high-density lipoprotein cholesterol and breast cancer risk by menopausal status, body mass index, and hormonal receptor in Korea. Can Epidemiol Pre Biomark 2009; 18: 508–515.
[14] Cedó L, Reddy ST, Mato E, Blanco-Vaca F, Escolà-Gil JC. HDL and LDL: Potential new players in breast cancer development. J ClinMed 2019; 8: 853.
[15] Raza U, Asif MR, Rehman AB, Sheikh S. Hyperlipidemia and hyperglycaemia in breast cancer patients is related to disease stage. Pak J Med Sci 2018; 34: 209-214.
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Cite This Article
  • APA Style

    Radhika Chowdary, Raghu Ram Pillarisetti, Vinod Kumar Verma, Radhika Korabathina, Syed Sultan Beevi. (2022). Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer. Cancer Research Journal, 10(2), 30-33. https://doi.org/10.11648/j.crj.20221002.12

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    ACS Style

    Radhika Chowdary; Raghu Ram Pillarisetti; Vinod Kumar Verma; Radhika Korabathina; Syed Sultan Beevi. Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer. Cancer Res. J. 2022, 10(2), 30-33. doi: 10.11648/j.crj.20221002.12

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    AMA Style

    Radhika Chowdary, Raghu Ram Pillarisetti, Vinod Kumar Verma, Radhika Korabathina, Syed Sultan Beevi. Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer. Cancer Res J. 2022;10(2):30-33. doi: 10.11648/j.crj.20221002.12

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  • @article{10.11648/j.crj.20221002.12,
      author = {Radhika Chowdary and Raghu Ram Pillarisetti and Vinod Kumar Verma and Radhika Korabathina and Syed Sultan Beevi},
      title = {Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer},
      journal = {Cancer Research Journal},
      volume = {10},
      number = {2},
      pages = {30-33},
      doi = {10.11648/j.crj.20221002.12},
      url = {https://doi.org/10.11648/j.crj.20221002.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221002.12},
      abstract = {Breast cancer ranks as the number one cancer among Indian females with survival as low as 66.1%. Relationship between cholesterol and breast cancer has triggered special interest due to their role in important cellular processes that steer toward carcinogenesis. The interplay between cholesterol and tumor development have been studied in experimental breast cancer models. However, epidemiological data reveal conflicting results, that need to be integrated and put into appropriate viewpoint. This study aims to investigate and corroborate the impact of total cholesterol (TC), triglyceride (TG), VLDL, LDL and HDL cholesterol on the disease-free and overall survival of patients with breast cancer. This study retrospectively analyzed 50 breast cancer patients who underwent radical surgery and attended follow-up visits at KIMS Hospitals. The blood lipid levels such as TC, TG, VLDL, LDL and HDL cholesterol were collected and analyzed from the database of Department of Laboratory Medicine. Potential prognostic factors including age, menopause, grade, receptor status, systemic cholesterol profile etc., were analyzed by univariate and multivariate analysis. TC less than 180mg/dL was associated with disease relapse in univariate analysis. TG, VLDL, LDL and HDL cholesterol were not significantly correlated either to disease-free or overall survival. Low systemic cholesterol level could be a significant prognostic factor for a shorter disease-free survival.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer
    AU  - Radhika Chowdary
    AU  - Raghu Ram Pillarisetti
    AU  - Vinod Kumar Verma
    AU  - Radhika Korabathina
    AU  - Syed Sultan Beevi
    Y1  - 2022/04/25
    PY  - 2022
    N1  - https://doi.org/10.11648/j.crj.20221002.12
    DO  - 10.11648/j.crj.20221002.12
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 30
    EP  - 33
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20221002.12
    AB  - Breast cancer ranks as the number one cancer among Indian females with survival as low as 66.1%. Relationship between cholesterol and breast cancer has triggered special interest due to their role in important cellular processes that steer toward carcinogenesis. The interplay between cholesterol and tumor development have been studied in experimental breast cancer models. However, epidemiological data reveal conflicting results, that need to be integrated and put into appropriate viewpoint. This study aims to investigate and corroborate the impact of total cholesterol (TC), triglyceride (TG), VLDL, LDL and HDL cholesterol on the disease-free and overall survival of patients with breast cancer. This study retrospectively analyzed 50 breast cancer patients who underwent radical surgery and attended follow-up visits at KIMS Hospitals. The blood lipid levels such as TC, TG, VLDL, LDL and HDL cholesterol were collected and analyzed from the database of Department of Laboratory Medicine. Potential prognostic factors including age, menopause, grade, receptor status, systemic cholesterol profile etc., were analyzed by univariate and multivariate analysis. TC less than 180mg/dL was associated with disease relapse in univariate analysis. TG, VLDL, LDL and HDL cholesterol were not significantly correlated either to disease-free or overall survival. Low systemic cholesterol level could be a significant prognostic factor for a shorter disease-free survival.
    VL  - 10
    IS  - 2
    ER  - 

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Author Information
  • Cancer Biology Division, KIMS Foundation and Research Centre, Krishna Institute of Medical Sciences (KIMS) Hospitals, Secunderabad, India

  • Ushalakshmi Centre for Breast Disease, Krishna Institute of Medical Sciences (KIMS) Hospitals, Secunderabad, India

  • Cancer Biology Division, KIMS Foundation and Research Centre, Krishna Institute of Medical Sciences (KIMS) Hospitals, Secunderabad, India

  • Cancer Biology Division, KIMS Foundation and Research Centre, Krishna Institute of Medical Sciences (KIMS) Hospitals, Secunderabad, India

  • Cancer Biology Division, KIMS Foundation and Research Centre, Krishna Institute of Medical Sciences (KIMS) Hospitals, Secunderabad, India

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