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Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma

Received: 21 December 2021     Accepted: 13 January 2022     Published: 21 January 2022
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Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. The failure rate of treatment for its subsets is still very high. CXC chemokine, secreted by a variety of cells, is a vital component in the immune process. It also participated in the growth, development, and metastasis of tumors. This study aimed to explore the prognosis of CXC chemokines in DLBCL and the relationship with immune infiltration through bioinformatics analysis. Methods: We systematically analyzed the expression level and prognostic value of CXC chemokines in DLBCL patients, and the correlation between CXC chemokines and tumor immune infiltration through databases, such as Oncomine, GEO, GEPIA, GeneMANIA, DAVID, HPA, GenomicScape, and TIMER2.0. Results: With the comprehensive analysis of different databases, we found that CXC chemokines (CXCL1/2/5/6/7/8/9/10/11/12/13/14) had significantly higher transcription levels in DLBCL patients vs. the control groups. The up-regulation mRNA levels of CXCL1/2/6/7/10/12 were associated with poor prognoses in DLBC patients. Further enrichment analysis of CXC chemokines and their receptors revealed that they were related to the infiltration and metastasis of immune cells. Besides, we found that the expression of CXCL9/10/11 were significantly correlated with tumor-infiltrating lymphocytes (TILs) (B cells, CD8+ T cells, CD4+ T cells, macrophages, Treg cells, and NK cells) and immune checkpoints in DLBCL. Conclusion: Our study may provide novel understandings for CXC chemokines as immunotherapeutic targets and prognostic biomarkers in diffuse large B-cell lymphoma through systematic analysis.

Published in Cancer Research Journal (Volume 10, Issue 1)
DOI 10.11648/j.crj.20221001.11
Page(s) 1-15
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Diffuse Large B-cell Lymphoma (DLBCL), Immune Infiltration, Prognosis, Biomarker, Bioinformatics Analysis

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  • APA Style

    Yuli Cao, Fenling Zhou, Cuilan Deng, Gexiu Liu. (2022). Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma. Cancer Research Journal, 10(1), 1-15. https://doi.org/10.11648/j.crj.20221001.11

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    ACS Style

    Yuli Cao; Fenling Zhou; Cuilan Deng; Gexiu Liu. Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma. Cancer Res. J. 2022, 10(1), 1-15. doi: 10.11648/j.crj.20221001.11

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    AMA Style

    Yuli Cao, Fenling Zhou, Cuilan Deng, Gexiu Liu. Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma. Cancer Res J. 2022;10(1):1-15. doi: 10.11648/j.crj.20221001.11

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  • @article{10.11648/j.crj.20221001.11,
      author = {Yuli Cao and Fenling Zhou and Cuilan Deng and Gexiu Liu},
      title = {Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma},
      journal = {Cancer Research Journal},
      volume = {10},
      number = {1},
      pages = {1-15},
      doi = {10.11648/j.crj.20221001.11},
      url = {https://doi.org/10.11648/j.crj.20221001.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221001.11},
      abstract = {Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. The failure rate of treatment for its subsets is still very high. CXC chemokine, secreted by a variety of cells, is a vital component in the immune process. It also participated in the growth, development, and metastasis of tumors. This study aimed to explore the prognosis of CXC chemokines in DLBCL and the relationship with immune infiltration through bioinformatics analysis. Methods: We systematically analyzed the expression level and prognostic value of CXC chemokines in DLBCL patients, and the correlation between CXC chemokines and tumor immune infiltration through databases, such as Oncomine, GEO, GEPIA, GeneMANIA, DAVID, HPA, GenomicScape, and TIMER2.0. Results: With the comprehensive analysis of different databases, we found that CXC chemokines (CXCL1/2/5/6/7/8/9/10/11/12/13/14) had significantly higher transcription levels in DLBCL patients vs. the control groups. The up-regulation mRNA levels of CXCL1/2/6/7/10/12 were associated with poor prognoses in DLBC patients. Further enrichment analysis of CXC chemokines and their receptors revealed that they were related to the infiltration and metastasis of immune cells. Besides, we found that the expression of CXCL9/10/11 were significantly correlated with tumor-infiltrating lymphocytes (TILs) (B cells, CD8+ T cells, CD4+ T cells, macrophages, Treg cells, and NK cells) and immune checkpoints in DLBCL. Conclusion: Our study may provide novel understandings for CXC chemokines as immunotherapeutic targets and prognostic biomarkers in diffuse large B-cell lymphoma through systematic analysis.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma
    AU  - Yuli Cao
    AU  - Fenling Zhou
    AU  - Cuilan Deng
    AU  - Gexiu Liu
    Y1  - 2022/01/21
    PY  - 2022
    N1  - https://doi.org/10.11648/j.crj.20221001.11
    DO  - 10.11648/j.crj.20221001.11
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 1
    EP  - 15
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20221001.11
    AB  - Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. The failure rate of treatment for its subsets is still very high. CXC chemokine, secreted by a variety of cells, is a vital component in the immune process. It also participated in the growth, development, and metastasis of tumors. This study aimed to explore the prognosis of CXC chemokines in DLBCL and the relationship with immune infiltration through bioinformatics analysis. Methods: We systematically analyzed the expression level and prognostic value of CXC chemokines in DLBCL patients, and the correlation between CXC chemokines and tumor immune infiltration through databases, such as Oncomine, GEO, GEPIA, GeneMANIA, DAVID, HPA, GenomicScape, and TIMER2.0. Results: With the comprehensive analysis of different databases, we found that CXC chemokines (CXCL1/2/5/6/7/8/9/10/11/12/13/14) had significantly higher transcription levels in DLBCL patients vs. the control groups. The up-regulation mRNA levels of CXCL1/2/6/7/10/12 were associated with poor prognoses in DLBC patients. Further enrichment analysis of CXC chemokines and their receptors revealed that they were related to the infiltration and metastasis of immune cells. Besides, we found that the expression of CXCL9/10/11 were significantly correlated with tumor-infiltrating lymphocytes (TILs) (B cells, CD8+ T cells, CD4+ T cells, macrophages, Treg cells, and NK cells) and immune checkpoints in DLBCL. Conclusion: Our study may provide novel understandings for CXC chemokines as immunotherapeutic targets and prognostic biomarkers in diffuse large B-cell lymphoma through systematic analysis.
    VL  - 10
    IS  - 1
    ER  - 

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Author Information
  • Institute of Hematology, Jinan University, Guangzhou, China

  • Institute of Hematology, Jinan University, Guangzhou, China

  • Department of Hematology, The First Affiliated Hospital, Jinan University, Guangzhou, China

  • Institute of Hematology, Jinan University, Guangzhou, China

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