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Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus

Received: 13 January 2018     Accepted: 29 January 2018     Published: 7 March 2018
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Abstract

Malignant cancer cells exhibit uncontrollable high proliferation similarly to meristematic cells of seeds, this led to the establishment that agents capable of producing antiproliferative effects are potential anticancer agents. The experimental plant used for this research was Sorghum bicolor seeds. The sole aim of this research work is to unveil the antiproliferative potential of Detarium senegalense and to evaluate the antiproliferative activity of leaf extract of Cymbopogon citratus on radicle length of Sorghum bicolor seeds. The three extracts were prepared at concentrations of 10, 20, 40, 60, 80 and 100 mg/cm3 as well as methotrexate (reference standard) at concentration of 0.05 mg/cm3. The growth lengths were measured at 24, 48 and 72 hours of the experiment and expressed as percentage inhibition and percentage growth. The extracts produced considerable amount of antiproliferative effect on the radicle length of the seeds. The antiproliferative activity of the three extracts were concentration (dose) dependent, as the concentration of the extracts of leaves of D. senegalense increases, the percentage inhibition also increases, with a percentage of 89.47 % at an optimum concentration of 100 mg/cm3. Similarly, D. senegalense stem bark and C. citratus leaves showed percentage inhibition which corresponds to 73.68 % at optimum concentration of 100 mg/cm3 and 86.84 % at an optimum concentration of 80 mg/cm3 after the 72 hours of the incubation period. This research work however, has unveiled the use of D. senegalense as potential therapeutics for cancer treatment especially in developing countries, and has added a new-found knowledge to science.

Published in Cancer Research Journal (Volume 6, Issue 2)
DOI 10.11648/j.crj.20180602.11
Page(s) 38-46
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Anticancer Agent, Antiproliferative Activity, Sorghum bicolor, Phytochemicals

References
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Cite This Article
  • APA Style

    Francis Agada, Chika Muhammad, Ahmad Uba, Halilu Emmanuel Mshelia, Halima Lawal Zubairu. (2018). Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus. Cancer Research Journal, 6(2), 38-46. https://doi.org/10.11648/j.crj.20180602.11

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    ACS Style

    Francis Agada; Chika Muhammad; Ahmad Uba; Halilu Emmanuel Mshelia; Halima Lawal Zubairu. Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus. Cancer Res. J. 2018, 6(2), 38-46. doi: 10.11648/j.crj.20180602.11

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    AMA Style

    Francis Agada, Chika Muhammad, Ahmad Uba, Halilu Emmanuel Mshelia, Halima Lawal Zubairu. Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus. Cancer Res J. 2018;6(2):38-46. doi: 10.11648/j.crj.20180602.11

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  • @article{10.11648/j.crj.20180602.11,
      author = {Francis Agada and Chika Muhammad and Ahmad Uba and Halilu Emmanuel Mshelia and Halima Lawal Zubairu},
      title = {Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus},
      journal = {Cancer Research Journal},
      volume = {6},
      number = {2},
      pages = {38-46},
      doi = {10.11648/j.crj.20180602.11},
      url = {https://doi.org/10.11648/j.crj.20180602.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20180602.11},
      abstract = {Malignant cancer cells exhibit uncontrollable high proliferation similarly to meristematic cells of seeds, this led to the establishment that agents capable of producing antiproliferative effects are potential anticancer agents. The experimental plant used for this research was Sorghum bicolor seeds. The sole aim of this research work is to unveil the antiproliferative potential of Detarium senegalense and to evaluate the antiproliferative activity of leaf extract of Cymbopogon citratus on radicle length of Sorghum bicolor seeds. The three extracts were prepared at concentrations of 10, 20, 40, 60, 80 and 100 mg/cm3 as well as methotrexate (reference standard) at concentration of 0.05 mg/cm3. The growth lengths were measured at 24, 48 and 72 hours of the experiment and expressed as percentage inhibition and percentage growth. The extracts produced considerable amount of antiproliferative effect on the radicle length of the seeds. The antiproliferative activity of the three extracts were concentration (dose) dependent, as the concentration of the extracts of leaves of D. senegalense increases, the percentage inhibition also increases, with a percentage of 89.47 % at an optimum concentration of 100 mg/cm3. Similarly, D. senegalense stem bark and C. citratus leaves showed percentage inhibition which corresponds to 73.68 % at optimum concentration of 100 mg/cm3 and 86.84 % at an optimum concentration of 80 mg/cm3 after the 72 hours of the incubation period. This research work however, has unveiled the use of D. senegalense as potential therapeutics for cancer treatment especially in developing countries, and has added a new-found knowledge to science.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus
    AU  - Francis Agada
    AU  - Chika Muhammad
    AU  - Ahmad Uba
    AU  - Halilu Emmanuel Mshelia
    AU  - Halima Lawal Zubairu
    Y1  - 2018/03/07
    PY  - 2018
    N1  - https://doi.org/10.11648/j.crj.20180602.11
    DO  - 10.11648/j.crj.20180602.11
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 38
    EP  - 46
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20180602.11
    AB  - Malignant cancer cells exhibit uncontrollable high proliferation similarly to meristematic cells of seeds, this led to the establishment that agents capable of producing antiproliferative effects are potential anticancer agents. The experimental plant used for this research was Sorghum bicolor seeds. The sole aim of this research work is to unveil the antiproliferative potential of Detarium senegalense and to evaluate the antiproliferative activity of leaf extract of Cymbopogon citratus on radicle length of Sorghum bicolor seeds. The three extracts were prepared at concentrations of 10, 20, 40, 60, 80 and 100 mg/cm3 as well as methotrexate (reference standard) at concentration of 0.05 mg/cm3. The growth lengths were measured at 24, 48 and 72 hours of the experiment and expressed as percentage inhibition and percentage growth. The extracts produced considerable amount of antiproliferative effect on the radicle length of the seeds. The antiproliferative activity of the three extracts were concentration (dose) dependent, as the concentration of the extracts of leaves of D. senegalense increases, the percentage inhibition also increases, with a percentage of 89.47 % at an optimum concentration of 100 mg/cm3. Similarly, D. senegalense stem bark and C. citratus leaves showed percentage inhibition which corresponds to 73.68 % at optimum concentration of 100 mg/cm3 and 86.84 % at an optimum concentration of 80 mg/cm3 after the 72 hours of the incubation period. This research work however, has unveiled the use of D. senegalense as potential therapeutics for cancer treatment especially in developing countries, and has added a new-found knowledge to science.
    VL  - 6
    IS  - 2
    ER  - 

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Author Information
  • Department of Pure and Applied Chemistry, Faculty of Science, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Pure and Applied Chemistry, Faculty of Science, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Medicinal Chemistry and Quality Control, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria

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