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Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells

Received: 4 August 2016     Accepted: 26 August 2016     Published: 21 September 2016
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Abstract

Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.

Published in Cancer Research Journal (Volume 4, Issue 5)
DOI 10.11648/j.crj.20160405.11
Page(s) 69-72
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Antioxidants, Organ Perfusion, Oxidative Stress, Micronutrients, HCC, Hepatocarcinoma

References
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[15] Torricelli P., Ferorelli P., De Martino A., Antonelli F. Beninati S.. Preventive Effects of A Mixture of Micronutrients with Antioxidative Properties on Experimentally Induced Prostate Hyperplasia, American Journal of Life Sciences. 2013; 1 (1): 22-26.
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Cite This Article
  • APA Style

    Torricelli Piera, Ferorelli Pasquale, Shevchenko Anna, Antonelli Francesco, Siciliano Alberto, et al. (2016). Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells. Cancer Research Journal, 4(5), 69-72. https://doi.org/10.11648/j.crj.20160405.11

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    ACS Style

    Torricelli Piera; Ferorelli Pasquale; Shevchenko Anna; Antonelli Francesco; Siciliano Alberto, et al. Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells. Cancer Res. J. 2016, 4(5), 69-72. doi: 10.11648/j.crj.20160405.11

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    AMA Style

    Torricelli Piera, Ferorelli Pasquale, Shevchenko Anna, Antonelli Francesco, Siciliano Alberto, et al. Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells. Cancer Res J. 2016;4(5):69-72. doi: 10.11648/j.crj.20160405.11

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  • @article{10.11648/j.crj.20160405.11,
      author = {Torricelli Piera and Ferorelli Pasquale and Shevchenko Anna and Antonelli Francesco and Siciliano Alberto and De Martino Angelo and Beninati Simone},
      title = {Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells},
      journal = {Cancer Research Journal},
      volume = {4},
      number = {5},
      pages = {69-72},
      doi = {10.11648/j.crj.20160405.11},
      url = {https://doi.org/10.11648/j.crj.20160405.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160405.11},
      abstract = {Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.},
     year = {2016}
    }
    

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    T1  - Perfusion of Multiple Micronutrients Supplement of HCC-Invaded Human Liver Reduces Oxidative Stress and Proliferation of Cancer Cells
    AU  - Torricelli Piera
    AU  - Ferorelli Pasquale
    AU  - Shevchenko Anna
    AU  - Antonelli Francesco
    AU  - Siciliano Alberto
    AU  - De Martino Angelo
    AU  - Beninati Simone
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    N1  - https://doi.org/10.11648/j.crj.20160405.11
    DO  - 10.11648/j.crj.20160405.11
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 69
    EP  - 72
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20160405.11
    AB  - Administration of the chemotherapeutic agent by organ perfusion is more effective than the systemic administration. The active drug is reached by the tumor, to a higher concentration, and normal tissues are spared from major damages. The perfusion of various areas of the body is a recent goal of the experimental and clinical trials. Fatal malignancies observed in humans occur mainly in the abdominal area of the body, The development of a clinically applicable technique for the perfusion of this area is desirable. This report covers the laboratory studies, carried out in the development of a liver perfusion technique for chemotherapy. The results obtained have allowed us to highlight that, the potential anticancer activity of Citozym, a micronutrients supplement, is likely the result of the inhibition of oxidative stress. This work is the preliminary evidence, of the possible mechanism by which Citozym exerts its antineoplastic activity.
    VL  - 4
    IS  - 5
    ER  - 

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Author Information
  • Department SPES, University of Molise, Campobasso, Italy

  • University of Tor Vergata, Department of Biology, Rome, Italy

  • People’s Friendship University of Russia, Moscow, Russia

  • University of Tor Vergata, Department of Biology, Rome, Italy

  • University of Tor Vergata, Department of Biology, Rome, Italy

  • University of Tor Vergata, Department of Biology, Rome, Italy

  • University of Tor Vergata, Department of Biology, Rome, Italy

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