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Lymphocytopenia and Cytotoxic Therapy in Patients with Advanced Ovarian Cancer

Received: 13 April 2015     Accepted: 25 April 2015     Published: 12 May 2015
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Abstract

The relationship between 5-year survival and the mean number of circulating lymphocytes during 1 month after beginning a combined therapy was investigated in 175 patients with advanced epithelial ovarian cancer to understand why myelosuppression caused by a cytotoxic treatment is almost inseparable from its benefit. Patients received a combined therapy consisting of primary cytoreductive surgery followed by different systemic treatments according to three schemes: conventional chemotherapy with cisplatinum and cyclophosphanum (CP), conventional chemotherapy with paclitaxel and carboplatinum (TP), or lower-half body irradiation (LHBI). The TP scheme included premedication with dexamethasone. The LHBI involve irradiation with a total dose of 9 Gy (3 Gy daily) in patients with primary disease. LHBI with a total dose of 1 Gy (0.1 Gy daily) was used for patients with primary disease or relapse. The LHBI treatment included five final courses of thiophosphamide/5-fluorouracil for patients with primary cancer or conventional local radiotherapy up to a total dose of 30 Gy (2 Gy daily) for relapsed patients. Survival curves were analyzed by exponential approximation, and 5-year exponential mortality rates were calculated. The mortality rates were compared with the relative decline in the mean number of circulating lymphocytes after 1 month of therapy. If pretreatment lymphocytopenia did not exceed 0.7 109 cells /L, a linear dependency of the exponential death rate from the relative deviation of cells in the range of 1.16 to 0.7 (p < 0.001) was observed. The inevitable side effect of cytotoxic cancer therapy in the form of lymphocytopenia sheds doubt on the actual existence of effective antineoplastic immunity; however, it provides a logical background of the morphogenic function of some circulating mononuclear cells in relation to proliferating tissues, including malignant tissues.

Published in Cancer Research Journal (Volume 3, Issue 3)
DOI 10.11648/j.crj.20150303.11
Page(s) 47-51
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Cytotoxic Therapy, Death Rates, Lymphocytopenia, Myelosuppression, Ovarian Cancer, Survival

References
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  • APA Style

    Alexei N. Shoutko, Ludmila E. Yurkova, Kseniya S. Borodulya, Ludmila P. Ekimova. (2015). Lymphocytopenia and Cytotoxic Therapy in Patients with Advanced Ovarian Cancer. Cancer Research Journal, 3(3), 47-51. https://doi.org/10.11648/j.crj.20150303.11

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    ACS Style

    Alexei N. Shoutko; Ludmila E. Yurkova; Kseniya S. Borodulya; Ludmila P. Ekimova. Lymphocytopenia and Cytotoxic Therapy in Patients with Advanced Ovarian Cancer. Cancer Res. J. 2015, 3(3), 47-51. doi: 10.11648/j.crj.20150303.11

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    AMA Style

    Alexei N. Shoutko, Ludmila E. Yurkova, Kseniya S. Borodulya, Ludmila P. Ekimova. Lymphocytopenia and Cytotoxic Therapy in Patients with Advanced Ovarian Cancer. Cancer Res J. 2015;3(3):47-51. doi: 10.11648/j.crj.20150303.11

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  • @article{10.11648/j.crj.20150303.11,
      author = {Alexei N. Shoutko and Ludmila E. Yurkova and Kseniya S. Borodulya and Ludmila P. Ekimova},
      title = {Lymphocytopenia and Cytotoxic Therapy in Patients with Advanced Ovarian Cancer},
      journal = {Cancer Research Journal},
      volume = {3},
      number = {3},
      pages = {47-51},
      doi = {10.11648/j.crj.20150303.11},
      url = {https://doi.org/10.11648/j.crj.20150303.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20150303.11},
      abstract = {The relationship between 5-year survival and the mean number of circulating lymphocytes during 1 month after beginning a combined therapy was investigated in 175 patients with advanced epithelial ovarian cancer to understand why myelosuppression caused by a cytotoxic treatment is almost inseparable from its benefit. Patients received a combined therapy consisting of primary cytoreductive surgery followed by different systemic treatments according to three schemes: conventional chemotherapy with cisplatinum and cyclophosphanum (CP), conventional chemotherapy with paclitaxel and carboplatinum (TP), or lower-half body irradiation (LHBI). The TP scheme included premedication with dexamethasone. The LHBI involve irradiation with a total dose of 9 Gy (3 Gy daily) in patients with primary disease. LHBI with a total dose of 1 Gy (0.1 Gy daily) was used for patients with primary disease or relapse. The LHBI treatment included five final courses of thiophosphamide/5-fluorouracil for patients with primary cancer or conventional local radiotherapy up to a total dose of 30 Gy (2 Gy daily) for relapsed patients. Survival curves were analyzed by exponential approximation, and 5-year exponential mortality rates were calculated. The mortality rates were compared with the relative decline in the mean number of circulating lymphocytes after 1 month of therapy. If pretreatment lymphocytopenia did not exceed 0.7 109 cells /L, a linear dependency of the exponential death rate from the relative deviation of cells in the range of 1.16 to 0.7 (p < 0.001) was observed. The inevitable side effect of cytotoxic cancer therapy in the form of lymphocytopenia sheds doubt on the actual existence of effective antineoplastic immunity; however, it provides a logical background of the morphogenic function of some circulating mononuclear cells in relation to proliferating tissues, including malignant tissues.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Lymphocytopenia and Cytotoxic Therapy in Patients with Advanced Ovarian Cancer
    AU  - Alexei N. Shoutko
    AU  - Ludmila E. Yurkova
    AU  - Kseniya S. Borodulya
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    AB  - The relationship between 5-year survival and the mean number of circulating lymphocytes during 1 month after beginning a combined therapy was investigated in 175 patients with advanced epithelial ovarian cancer to understand why myelosuppression caused by a cytotoxic treatment is almost inseparable from its benefit. Patients received a combined therapy consisting of primary cytoreductive surgery followed by different systemic treatments according to three schemes: conventional chemotherapy with cisplatinum and cyclophosphanum (CP), conventional chemotherapy with paclitaxel and carboplatinum (TP), or lower-half body irradiation (LHBI). The TP scheme included premedication with dexamethasone. The LHBI involve irradiation with a total dose of 9 Gy (3 Gy daily) in patients with primary disease. LHBI with a total dose of 1 Gy (0.1 Gy daily) was used for patients with primary disease or relapse. The LHBI treatment included five final courses of thiophosphamide/5-fluorouracil for patients with primary cancer or conventional local radiotherapy up to a total dose of 30 Gy (2 Gy daily) for relapsed patients. Survival curves were analyzed by exponential approximation, and 5-year exponential mortality rates were calculated. The mortality rates were compared with the relative decline in the mean number of circulating lymphocytes after 1 month of therapy. If pretreatment lymphocytopenia did not exceed 0.7 109 cells /L, a linear dependency of the exponential death rate from the relative deviation of cells in the range of 1.16 to 0.7 (p < 0.001) was observed. The inevitable side effect of cytotoxic cancer therapy in the form of lymphocytopenia sheds doubt on the actual existence of effective antineoplastic immunity; however, it provides a logical background of the morphogenic function of some circulating mononuclear cells in relation to proliferating tissues, including malignant tissues.
    VL  - 3
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    ER  - 

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Author Information
  • Laboratory of the development of radiation therapy methods, Federal Scientific Centre for Radiology and Surgical Technologies, Saint-Petersburg, Russian Federation

  • Division of Gynecologic Oncology, Federal Scientific Centre for Radiology and Surgical Technologies, Saint-Petersburg, Russian Federation

  • Division of Gynecologic Oncology, Federal Scientific Centre for Radiology and Surgical Technologies, Saint-Petersburg, Russian Federation

  • Laboratory of the development of radiation therapy methods, Federal Scientific Centre for Radiology and Surgical Technologies, Saint-Petersburg, Russian Federation

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