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Breast Cancer and Postmenopausal Obesity: the Risk Factors in this Relationship

Received: 16 February 2014     Published: 10 March 2014
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Abstract

The prevalence of obesity is increasing rapidly in both the developed and the developing countries, thus contributing to the occurrence of other diseases, e.g. hypertension, diabetes and breast cancer. Breast cancer involves a multifactorial process in which the surrounding microenvironment is known to be of great importance in the development and progression of the disease. Thus, adipose tissue, due to its immunological, metabolic and endocrine properties, may play a crucial role in the onset and progression of the disease. The relationship between obesity and breast cancer needs to be studied and characterized so that more effective treatments can be developed, faster and more secure diagnostic and prognostic tests might emerge and, mainly, so that public policies can be designed to prevent the increasing incidence of the disease related to obesity. The main hypotheses regarding the increased risk of developing breast cancer among obese women, i.e. sex hormones, adipokines, insulin and cytokines, are discussed in this review.

Published in Cancer Research Journal (Volume 2, Issue 1)
DOI 10.11648/j.crj.20140201.12
Page(s) 9-14
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Obesity, Breast cancer, Adipokines, Sex hormones, Cytokines, Insulin

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Cite This Article
  • APA Style

    Clarissa Germano Barp, Durinézio Jose de Almeida, Guilherme Barroso Langoni de Freitas. (2014). Breast Cancer and Postmenopausal Obesity: the Risk Factors in this Relationship. Cancer Research Journal, 2(1), 9-14. https://doi.org/10.11648/j.crj.20140201.12

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    ACS Style

    Clarissa Germano Barp; Durinézio Jose de Almeida; Guilherme Barroso Langoni de Freitas. Breast Cancer and Postmenopausal Obesity: the Risk Factors in this Relationship. Cancer Res. J. 2014, 2(1), 9-14. doi: 10.11648/j.crj.20140201.12

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    AMA Style

    Clarissa Germano Barp, Durinézio Jose de Almeida, Guilherme Barroso Langoni de Freitas. Breast Cancer and Postmenopausal Obesity: the Risk Factors in this Relationship. Cancer Res J. 2014;2(1):9-14. doi: 10.11648/j.crj.20140201.12

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  • @article{10.11648/j.crj.20140201.12,
      author = {Clarissa Germano Barp and Durinézio Jose de Almeida and Guilherme Barroso Langoni de Freitas},
      title = {Breast Cancer and Postmenopausal Obesity: the Risk Factors in this Relationship},
      journal = {Cancer Research Journal},
      volume = {2},
      number = {1},
      pages = {9-14},
      doi = {10.11648/j.crj.20140201.12},
      url = {https://doi.org/10.11648/j.crj.20140201.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20140201.12},
      abstract = {The prevalence of obesity is increasing rapidly in both the developed and the developing countries, thus contributing to the occurrence of other diseases, e.g. hypertension, diabetes and breast cancer. Breast cancer involves a multifactorial process in which the surrounding microenvironment is known to be of great importance in the development and progression of the disease. Thus, adipose tissue, due to its immunological, metabolic and endocrine properties, may play a crucial role in the onset and progression of the disease. The relationship between obesity and breast cancer needs to be studied and characterized so that more effective treatments can be developed, faster and more secure diagnostic and prognostic tests might emerge and, mainly, so that public policies can be designed to prevent the increasing incidence of the disease related to obesity. The main hypotheses regarding the increased risk of developing breast cancer among obese women, i.e. sex hormones, adipokines, insulin and cytokines, are discussed in this review.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Breast Cancer and Postmenopausal Obesity: the Risk Factors in this Relationship
    AU  - Clarissa Germano Barp
    AU  - Durinézio Jose de Almeida
    AU  - Guilherme Barroso Langoni de Freitas
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    N1  - https://doi.org/10.11648/j.crj.20140201.12
    DO  - 10.11648/j.crj.20140201.12
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 9
    EP  - 14
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20140201.12
    AB  - The prevalence of obesity is increasing rapidly in both the developed and the developing countries, thus contributing to the occurrence of other diseases, e.g. hypertension, diabetes and breast cancer. Breast cancer involves a multifactorial process in which the surrounding microenvironment is known to be of great importance in the development and progression of the disease. Thus, adipose tissue, due to its immunological, metabolic and endocrine properties, may play a crucial role in the onset and progression of the disease. The relationship between obesity and breast cancer needs to be studied and characterized so that more effective treatments can be developed, faster and more secure diagnostic and prognostic tests might emerge and, mainly, so that public policies can be designed to prevent the increasing incidence of the disease related to obesity. The main hypotheses regarding the increased risk of developing breast cancer among obese women, i.e. sex hormones, adipokines, insulin and cytokines, are discussed in this review.
    VL  - 2
    IS  - 1
    ER  - 

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Author Information
  • Department of Pharmacy, State University of Center-West, Camargo Varela de Sá, 03, Vila Carli, Guarapuava, Paraná, Brazil

  • Department of Biology, State University of Maringá. Colombo Avenue, 5790, Zone 07, Maringá, Paraná, Brazil

  • Department of Pharmacy, State University of Center-West, Camargo Varela de Sá, 03, Vila Carli, Guarapuava, Paraná, Brazil

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