Clinical Neurology and Neuroscience

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Clinical and Evaluative Profile of Guillain-Barré Syndrome in Burkina Faso: Retrospective Study of 49 Patients Collected in 16 Years (2003-2018)

Received: Sep. 24, 2023    Accepted: Oct. 17, 2023    Published: Nov. 09, 2023
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Abstract

Introduction: The aim of our study was to describe the epidemiological, paraclinical and clinical profile of Guillain-Barré syndrome (GBS) in the University Hospitals of Ouagadougou, Burkina Faso. Patients and methods: This was a retrospective, multicenter, descriptive study of the records of patients hospitalized for GBS in 3 Ouagadougou University Hospitals for a period of 16 years, from March 2003 to May 2018. Included in the study were the records of patients aged ≥ 16 years who were hospitalized for GBS during the study period, according to the modified Brighton diagnostic criteria. Patients who were HIV-positive or had cytorachy > 10 elements/mm3 were not included. Socio-demographic, climatic, clinical variables, Electroneuromyography (ENMG) data, cerebro spinal fluid (CSF) examination and evolution were studied. The intra-hospital clinical course of patients was assessed according to the Guillain-Barré Disability Scale (GBDS). Results: A total of 49 cases of GBS were hospitalized. The average age was 36 years, with a predominance of females (51%) and during the cold dry season (40.8%). In the state phase, all patients had a motor deficit of all 4 limbs and 15 patients (30.6%) had dysautonomia. The mean durations of the extension and plateau phases were 10 days and 19 days respectively. At the ENMG, the axonal form (71.4%) predominated. Pulmonary infection (36.7%), exacerbation of hypertension (32.6%) and electrolyte disorders (23%) were the most frequently encountered intra-hospital complications. Intra-hospital mortality was 18.4%. Among the survivors, 30% were confined to a wheelchair with or without respiratory assistance. After univariate analysis, intra-hospital infectious complications (p=0.04), exposure to mechanical ventilation (p=0.05) and severe clinical presentations (p=0.005) were the variables significantly influencing intra-hospital mortality. Conclusion: GBS affects more often young patients, occurs more frequently in the cold dry season. It is characterized by a late hospitalization of the patients, a predominant axonal damage. Early admission of patients, early use of quality intensive care units, availability of Polyvalent Intravenous immunoglobulin and plasma exchange, will significantly improve the prognosis of GBS in Burkina Faso and Sub-Saharan Africa (SSA).

DOI 10.11648/j.cnn.20230703.13
Published in Clinical Neurology and Neuroscience ( Volume 7, Issue 3, September 2023 )
Page(s) 56-64
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Guillain-Barré Syndrome, Dysautonomy, Cold Dry Season, Mortality, Burkina Faso

References
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Cite This Article
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    Labodi Lompo, D., M P Kaboré, R., Mariam Ouédraogo, A., Cissé, K., Ramdé, A., et al. (2023). Clinical and Evaluative Profile of Guillain-Barré Syndrome in Burkina Faso: Retrospective Study of 49 Patients Collected in 16 Years (2003-2018). Clinical Neurology and Neuroscience, 7(3), 56-64. https://doi.org/10.11648/j.cnn.20230703.13

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    Labodi Lompo, D.; M P Kaboré, R.; Mariam Ouédraogo, A.; Cissé, K.; Ramdé, A., et al. Clinical and Evaluative Profile of Guillain-Barré Syndrome in Burkina Faso: Retrospective Study of 49 Patients Collected in 16 Years (2003-2018). Clin. Neurol. Neurosci. 2023, 7(3), 56-64. doi: 10.11648/j.cnn.20230703.13

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    AMA Style

    Labodi Lompo D, M P Kaboré R, Mariam Ouédraogo A, Cissé K, Ramdé A, et al. Clinical and Evaluative Profile of Guillain-Barré Syndrome in Burkina Faso: Retrospective Study of 49 Patients Collected in 16 Years (2003-2018). Clin Neurol Neurosci. 2023;7(3):56-64. doi: 10.11648/j.cnn.20230703.13

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  • @article{10.11648/j.cnn.20230703.13,
      author = {Djingri Labodi Lompo and Raphael M P Kaboré and Adja Mariam Ouédraogo and Kadari Cissé and Adama Ramdé and Christian Napon},
      title = {Clinical and Evaluative Profile of Guillain-Barré Syndrome in Burkina Faso: Retrospective Study of 49 Patients Collected in 16 Years (2003-2018)},
      journal = {Clinical Neurology and Neuroscience},
      volume = {7},
      number = {3},
      pages = {56-64},
      doi = {10.11648/j.cnn.20230703.13},
      url = {https://doi.org/10.11648/j.cnn.20230703.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.cnn.20230703.13},
      abstract = {Introduction: The aim of our study was to describe the epidemiological, paraclinical and clinical profile of Guillain-Barré syndrome (GBS) in the University Hospitals of Ouagadougou, Burkina Faso. Patients and methods: This was a retrospective, multicenter, descriptive study of the records of patients hospitalized for GBS in 3 Ouagadougou University Hospitals for a period of 16 years, from March 2003 to May 2018. Included in the study were the records of patients aged ≥ 16 years who were hospitalized for GBS during the study period, according to the modified Brighton diagnostic criteria. Patients who were HIV-positive or had cytorachy > 10 elements/mm3 were not included. Socio-demographic, climatic, clinical variables, Electroneuromyography (ENMG) data, cerebro spinal fluid (CSF) examination and evolution were studied. The intra-hospital clinical course of patients was assessed according to the Guillain-Barré Disability Scale (GBDS). Results: A total of 49 cases of GBS were hospitalized. The average age was 36 years, with a predominance of females (51%) and during the cold dry season (40.8%). In the state phase, all patients had a motor deficit of all 4 limbs and 15 patients (30.6%) had dysautonomia. The mean durations of the extension and plateau phases were 10 days and 19 days respectively. At the ENMG, the axonal form (71.4%) predominated. Pulmonary infection (36.7%), exacerbation of hypertension (32.6%) and electrolyte disorders (23%) were the most frequently encountered intra-hospital complications. Intra-hospital mortality was 18.4%. Among the survivors, 30% were confined to a wheelchair with or without respiratory assistance. After univariate analysis, intra-hospital infectious complications (p=0.04), exposure to mechanical ventilation (p=0.05) and severe clinical presentations (p=0.005) were the variables significantly influencing intra-hospital mortality. Conclusion: GBS affects more often young patients, occurs more frequently in the cold dry season. It is characterized by a late hospitalization of the patients, a predominant axonal damage. Early admission of patients, early use of quality intensive care units, availability of Polyvalent Intravenous immunoglobulin and plasma exchange, will significantly improve the prognosis of GBS in Burkina Faso and Sub-Saharan Africa (SSA).
    },
     year = {2023}
    }
    

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    T1  - Clinical and Evaluative Profile of Guillain-Barré Syndrome in Burkina Faso: Retrospective Study of 49 Patients Collected in 16 Years (2003-2018)
    AU  - Djingri Labodi Lompo
    AU  - Raphael M P Kaboré
    AU  - Adja Mariam Ouédraogo
    AU  - Kadari Cissé
    AU  - Adama Ramdé
    AU  - Christian Napon
    Y1  - 2023/11/09
    PY  - 2023
    N1  - https://doi.org/10.11648/j.cnn.20230703.13
    DO  - 10.11648/j.cnn.20230703.13
    T2  - Clinical Neurology and Neuroscience
    JF  - Clinical Neurology and Neuroscience
    JO  - Clinical Neurology and Neuroscience
    SP  - 56
    EP  - 64
    PB  - Science Publishing Group
    SN  - 2578-8930
    UR  - https://doi.org/10.11648/j.cnn.20230703.13
    AB  - Introduction: The aim of our study was to describe the epidemiological, paraclinical and clinical profile of Guillain-Barré syndrome (GBS) in the University Hospitals of Ouagadougou, Burkina Faso. Patients and methods: This was a retrospective, multicenter, descriptive study of the records of patients hospitalized for GBS in 3 Ouagadougou University Hospitals for a period of 16 years, from March 2003 to May 2018. Included in the study were the records of patients aged ≥ 16 years who were hospitalized for GBS during the study period, according to the modified Brighton diagnostic criteria. Patients who were HIV-positive or had cytorachy > 10 elements/mm3 were not included. Socio-demographic, climatic, clinical variables, Electroneuromyography (ENMG) data, cerebro spinal fluid (CSF) examination and evolution were studied. The intra-hospital clinical course of patients was assessed according to the Guillain-Barré Disability Scale (GBDS). Results: A total of 49 cases of GBS were hospitalized. The average age was 36 years, with a predominance of females (51%) and during the cold dry season (40.8%). In the state phase, all patients had a motor deficit of all 4 limbs and 15 patients (30.6%) had dysautonomia. The mean durations of the extension and plateau phases were 10 days and 19 days respectively. At the ENMG, the axonal form (71.4%) predominated. Pulmonary infection (36.7%), exacerbation of hypertension (32.6%) and electrolyte disorders (23%) were the most frequently encountered intra-hospital complications. Intra-hospital mortality was 18.4%. Among the survivors, 30% were confined to a wheelchair with or without respiratory assistance. After univariate analysis, intra-hospital infectious complications (p=0.04), exposure to mechanical ventilation (p=0.05) and severe clinical presentations (p=0.005) were the variables significantly influencing intra-hospital mortality. Conclusion: GBS affects more often young patients, occurs more frequently in the cold dry season. It is characterized by a late hospitalization of the patients, a predominant axonal damage. Early admission of patients, early use of quality intensive care units, availability of Polyvalent Intravenous immunoglobulin and plasma exchange, will significantly improve the prognosis of GBS in Burkina Faso and Sub-Saharan Africa (SSA).
    
    VL  - 7
    IS  - 3
    ER  - 

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Author Information
  • Tingandogo University Hospital, Health Sciences Training and Research Unit, Joseph Ki-Zerbo University of Ouagadougou, Ouagadougou, Burkina Faso

  • Tingandogo University Hospital, Health Sciences Training and Research Unit, Joseph Ki-Zerbo University of Ouagadougou, Ouagadougou, Burkina Faso

  • Health Sciences Research Institute, Department of Medical Biology and Public Health of Ouagadougou, Ouagadougou, Burkina Faso

  • Health Sciences Research Institute, Department of Medical Biology and Public Health of Ouagadougou, Ouagadougou, Burkina Faso

  • Tingandogo University Hospital, Health Sciences Training and Research Unit, Joseph Ki-Zerbo University of Ouagadougou, Ouagadougou, Burkina Faso

  • Bogodogo University Hospital, Health Sciences Training and Research Unit, Joseph Ki-Zerbo University of Ouagadougou, Ouagadougou, Burkina Faso

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