@article{10.11648/j.cajph.20251106.17,
  author = {Amadou Dieng and Serigne Ndame Dieng and Khadim Seck and Mbathio Diop and Cheikh Ahmadou Bamba Faye and Aida Kanoute and Massamba Diouf and Cheikh Mouhamadou Mbacke Lo and Daouda Faye},
  title = {HPV Prevalence in Oral Cavity Cancers in West Africa: Systematic Review and Meta-analysis
},
  journal = {Central African Journal of Public Health},
  volume = {11},
  number = {6},
  pages = {385-395},
  doi = {10.11648/j.cajph.20251106.17},
  url = {https://doi.org/10.11648/j.cajph.20251106.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20251106.17},
  abstract = {Background: Human papillomavirus (HPV) infection has been established as a risk factor for oropharyngeal cancers, but its role in oral cavity cancers (OCC) remains controversial, particularly in West Africa where data are limited. Objective: To determine the prevalence of HPV infection in oral cavity cancers in West Africa through systematic review and meta-analysis. Methods: This systematic review followed PRISMA guidelines and was registered in PROSPERO (CRD42025644928). We searched MEDLINE, AJOL, ScienceDirect, Web of Science, EMBASE, Cochrane Library, and Scopus for studies published from 2000 to 2024. Eligible studies reported HPV prevalence in histologically confirmed oral cavity cancers in West African populations. Random-effects meta-analysis was performed using Freeman-Tukey transformation. Results: Nine studies from four West African countries (Senegal, Ghana, Nigeria, Burkina Faso) including 415 oral cavity cancer patients were analyzed. Overall pooled HPV prevalence was 6.59% (95% CI: 2.52-10.67%). Substantial geographical heterogeneity was observed (I² = 74.91%), with prevalences ranging from 0.75% in Senegal to 18.33% in Burkina Faso. Most studies used cross-sectional or retrospective designs analyzing preserved biopsy samples. HPV-16 was the most frequently detected high-risk genotype. Conclusion: HPV prevalence in oral cavity cancers is relatively low in West Africa compared to other global regions, with significant inter-country variation. These findings suggest that traditional risk factors may play a more prominent role than HPV in oral cavity carcinogenesis in this region. Standardized multicenter studies with larger sample sizes are needed to better characterize HPV distribution patterns.
},
 year = {2025}
}

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TY  - JOUR
T1  - HPV Prevalence in Oral Cavity Cancers in West Africa: Systematic Review and Meta-analysis

AU  - Amadou Dieng
AU  - Serigne Ndame Dieng
AU  - Khadim Seck
AU  - Mbathio Diop
AU  - Cheikh Ahmadou Bamba Faye
AU  - Aida Kanoute
AU  - Massamba Diouf
AU  - Cheikh Mouhamadou Mbacke Lo
AU  - Daouda Faye
Y1  - 2025/12/03
PY  - 2025
N1  - https://doi.org/10.11648/j.cajph.20251106.17
DO  - 10.11648/j.cajph.20251106.17
T2  - Central African Journal of Public Health
JF  - Central African Journal of Public Health
JO  - Central African Journal of Public Health
SP  - 385
EP  - 395
PB  - Science Publishing Group
SN  - 2575-5781
UR  - https://doi.org/10.11648/j.cajph.20251106.17
AB  - Background: Human papillomavirus (HPV) infection has been established as a risk factor for oropharyngeal cancers, but its role in oral cavity cancers (OCC) remains controversial, particularly in West Africa where data are limited. Objective: To determine the prevalence of HPV infection in oral cavity cancers in West Africa through systematic review and meta-analysis. Methods: This systematic review followed PRISMA guidelines and was registered in PROSPERO (CRD42025644928). We searched MEDLINE, AJOL, ScienceDirect, Web of Science, EMBASE, Cochrane Library, and Scopus for studies published from 2000 to 2024. Eligible studies reported HPV prevalence in histologically confirmed oral cavity cancers in West African populations. Random-effects meta-analysis was performed using Freeman-Tukey transformation. Results: Nine studies from four West African countries (Senegal, Ghana, Nigeria, Burkina Faso) including 415 oral cavity cancer patients were analyzed. Overall pooled HPV prevalence was 6.59% (95% CI: 2.52-10.67%). Substantial geographical heterogeneity was observed (I² = 74.91%), with prevalences ranging from 0.75% in Senegal to 18.33% in Burkina Faso. Most studies used cross-sectional or retrospective designs analyzing preserved biopsy samples. HPV-16 was the most frequently detected high-risk genotype. Conclusion: HPV prevalence in oral cavity cancers is relatively low in West Africa compared to other global regions, with significant inter-country variation. These findings suggest that traditional risk factors may play a more prominent role than HPV in oral cavity carcinogenesis in this region. Standardized multicenter studies with larger sample sizes are needed to better characterize HPV distribution patterns.

VL  - 11
IS  - 6
ER  - 

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