Advances in Surgical Sciences

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Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats

Received: Oct. 01, 2022    Accepted: Oct. 20, 2022    Published: Jun. 27, 2023
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Abstract

Background: Tiger nut tuberis very common and abundant in Nigeria. Aluminium chloride is the third must abundant metal present naturally on earth crust. Objective: The objective of thestudy was to assess the increase in rate of aluminium chloride exposure and toxicity on the pancreas of adult wistar rats. Aim: To evaluate the protective effect of ethanolic extract of tigernut on pancreas of adult wistar rats. Methods: In this study twenty five adult rats were used. The animals were grouped into a control group A and treatment groups B, C, D and E. Group A served as control and was administered orally with normal saline, group B wasadministered orally with 500 mg/kg of aluminum chloride, group C, D and E were administered with 1250 mg/kg of the ethanolic extract of Cyperus esculentus only, 500 mg/kg of aluminum chloride followed by 2500 mg/kg of the ethanolic extract of Cyperus esculentus and 500 mg/kg of aluminum chloride followed by 3750 mg/kg of the ethanolic extract of Cyperus esculentus respectively. The treatment was for six weeks, weights of the rats were recorded weekly. Result: The histo-morphology of the pancreas revealed that group A showed the normal pancreatic histo-architecture, group B showed sign of inflammation and paucity of islet cells. Groups C, D and E showed normal pancreatic histomorphology. Conclusion: Tissue exposed to aluminum chloride showed fibrosis and inflammation due to toxicity while those exposed to tiger nut therapy showed recovery and regeneration of damaged cells thus indicating ameliorative role of tigernut seed.

DOI 10.11648/j.ass.20231101.14
Published in Advances in Surgical Sciences ( Volume 11, Issue 1, June 2023 )
Page(s) 17-21
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Ameliorative, Tigernut, Ethanolic Extract, Pancreas, Wistar Rats

References
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[2] Sanchez-Zapata, E., Fernandez-Lopez, J. and Angel P. J. (2012). Tigernut (Cyperus esculentus) commercialization: health aspects, composition, properties, and food applications. Comprehensive Reviews in Food Science and Food Safety. 11 (4): 36677.
[3] Okafor, J. N. C., Mordi, J. I., Ozumba, A. U., Solomon, H. M. and Olatunji, I. (2003).
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[6] Oladele, A. K., K. and Aina, J. O. (2007). Chemical composition and functional properties of flour from two varieties of tiger nut (Cyperus esculentus). African Journal of Biotechnology 6 (21): 2473-2476.
[7] Arafat, S. M., Gaafar, A. M., Basuny, A. M. and Nassef S. L. (2009). Chufa tubers (Cyperus esculentus) As a new source of food. World Applied Sciences Journal, 7 (2): 151-156.
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[15] Mason, D Tiger Nuts In: http://www.nvsuk.org.uk/growing_show_vegetables_1/tiger_nut.php2005. Accessed December, 2009.
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    Gudaji Abdullahi, Umar Zailani. (2023). Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats. Advances in Surgical Sciences, 11(1), 17-21. https://doi.org/10.11648/j.ass.20231101.14

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    ACS Style

    Gudaji Abdullahi; Umar Zailani. Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats. Adv. Surg. Sci. 2023, 11(1), 17-21. doi: 10.11648/j.ass.20231101.14

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    AMA Style

    Gudaji Abdullahi, Umar Zailani. Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats. Adv Surg Sci. 2023;11(1):17-21. doi: 10.11648/j.ass.20231101.14

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  • @article{10.11648/j.ass.20231101.14,
      author = {Gudaji Abdullahi and Umar Zailani},
      title = {Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats},
      journal = {Advances in Surgical Sciences},
      volume = {11},
      number = {1},
      pages = {17-21},
      doi = {10.11648/j.ass.20231101.14},
      url = {https://doi.org/10.11648/j.ass.20231101.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ass.20231101.14},
      abstract = {Background: Tiger nut tuberis very common and abundant in Nigeria. Aluminium chloride is the third must abundant metal present naturally on earth crust. Objective: The objective of thestudy was to assess the increase in rate of aluminium chloride exposure and toxicity on the pancreas of adult wistar rats. Aim: To evaluate the protective effect of ethanolic extract of tigernut on pancreas of adult wistar rats. Methods: In this study twenty five adult rats were used. The animals were grouped into a control group A and treatment groups B, C, D and E. Group A served as control and was administered orally with normal saline, group B wasadministered orally with 500 mg/kg of aluminum chloride, group C, D and E were administered with 1250 mg/kg of the ethanolic extract of Cyperus esculentus only, 500 mg/kg of aluminum chloride followed by 2500 mg/kg of the ethanolic extract of Cyperus esculentus and 500 mg/kg of aluminum chloride followed by 3750 mg/kg of the ethanolic extract of Cyperus esculentus respectively. The treatment was for six weeks, weights of the rats were recorded weekly. Result: The histo-morphology of the pancreas revealed that group A showed the normal pancreatic histo-architecture, group B showed sign of inflammation and paucity of islet cells. Groups C, D and E showed normal pancreatic histomorphology. Conclusion: Tissue exposed to aluminum chloride showed fibrosis and inflammation due to toxicity while those exposed to tiger nut therapy showed recovery and regeneration of damaged cells thus indicating ameliorative role of tigernut seed.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Ameliorative Effect of Ethanolic Extract of Tigernut on Aluminium Chloride Induced Pancreatic Histomorphological Changes on Adult Wistar Rats
    AU  - Gudaji Abdullahi
    AU  - Umar Zailani
    Y1  - 2023/06/27
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ass.20231101.14
    DO  - 10.11648/j.ass.20231101.14
    T2  - Advances in Surgical Sciences
    JF  - Advances in Surgical Sciences
    JO  - Advances in Surgical Sciences
    SP  - 17
    EP  - 21
    PB  - Science Publishing Group
    SN  - 2376-6182
    UR  - https://doi.org/10.11648/j.ass.20231101.14
    AB  - Background: Tiger nut tuberis very common and abundant in Nigeria. Aluminium chloride is the third must abundant metal present naturally on earth crust. Objective: The objective of thestudy was to assess the increase in rate of aluminium chloride exposure and toxicity on the pancreas of adult wistar rats. Aim: To evaluate the protective effect of ethanolic extract of tigernut on pancreas of adult wistar rats. Methods: In this study twenty five adult rats were used. The animals were grouped into a control group A and treatment groups B, C, D and E. Group A served as control and was administered orally with normal saline, group B wasadministered orally with 500 mg/kg of aluminum chloride, group C, D and E were administered with 1250 mg/kg of the ethanolic extract of Cyperus esculentus only, 500 mg/kg of aluminum chloride followed by 2500 mg/kg of the ethanolic extract of Cyperus esculentus and 500 mg/kg of aluminum chloride followed by 3750 mg/kg of the ethanolic extract of Cyperus esculentus respectively. The treatment was for six weeks, weights of the rats were recorded weekly. Result: The histo-morphology of the pancreas revealed that group A showed the normal pancreatic histo-architecture, group B showed sign of inflammation and paucity of islet cells. Groups C, D and E showed normal pancreatic histomorphology. Conclusion: Tissue exposed to aluminum chloride showed fibrosis and inflammation due to toxicity while those exposed to tiger nut therapy showed recovery and regeneration of damaged cells thus indicating ameliorative role of tigernut seed.
    VL  - 11
    IS  - 1
    ER  - 

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Author Information
  • Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Bayero University, Kano, Nigeria

  • Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Bayero University, Kano, Nigeria

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