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Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment

Received: 8 January 2020     Accepted: 31 January 2020     Published: 14 February 2020
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Abstract

PIH accounts significantly for maternal and perinatal mortality, especially in rural communities. The sudden onset of PIH and the lack of definitive case management is worrisome. The study analysed differential leucocytes count on PIH outcomes. This is a case-control study of 40 PIH (8 GH, 16 PE and 16 EC) and 60 normotensive women who visited the Bolgatanga Regional Hospital, Ghana. Data on socio-demographics, clinical history and laboratory evaluations on blood and placental tissues were collected and analysed. Lymphocytes count was markedly increased in PIH women, while total leucocytes, neutrophils and NLR were significantly decreased. Lymphocytes count increased with severity of PIH (p=0.0037). A correlation (r=-0.9565, p<0.0001) between lymphocyte and neutrophil counts was observed among PIH subjects. Oxidative stress was more associated with PIH compared to controls. Stillbirths was associated with PIH mothers with high leucocytes count. NLR (AUC; 0.857, p<0.0001) and lymphocytes count (AUC; 0.822, p<0.0001) were optimal for prognosis of PIH. Wide variations in NLR and lymphocytes count during pregnancy necessitates urgent attention.

Published in American Journal of Laboratory Medicine (Volume 5, Issue 1)
DOI 10.11648/j.ajlm.20200501.15
Page(s) 32-41
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Preeclampsia, Gestational Hypertension, Differential Leucocytes Count, Neutrophil-to-Lymphocyte Ratio, Risk Assessment, Stillbirth

References
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Cite This Article
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    Nafiu Amidu, Benedict Boateng Antuamwine, Martin Awe Akilla, William Kwame Boakye Ansah Owiredu, Otchere Addai-Mensah, et al. (2020). Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment. American Journal of Laboratory Medicine, 5(1), 32-41. https://doi.org/10.11648/j.ajlm.20200501.15

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    ACS Style

    Nafiu Amidu; Benedict Boateng Antuamwine; Martin Awe Akilla; William Kwame Boakye Ansah Owiredu; Otchere Addai-Mensah, et al. Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment. Am. J. Lab. Med. 2020, 5(1), 32-41. doi: 10.11648/j.ajlm.20200501.15

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    AMA Style

    Nafiu Amidu, Benedict Boateng Antuamwine, Martin Awe Akilla, William Kwame Boakye Ansah Owiredu, Otchere Addai-Mensah, et al. Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment. Am J Lab Med. 2020;5(1):32-41. doi: 10.11648/j.ajlm.20200501.15

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  • @article{10.11648/j.ajlm.20200501.15,
      author = {Nafiu Amidu and Benedict Boateng Antuamwine and Martin Awe Akilla and William Kwame Boakye Ansah Owiredu and Otchere Addai-Mensah and Peter Paul Dapare and Eric Mishio Bawa},
      title = {Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment},
      journal = {American Journal of Laboratory Medicine},
      volume = {5},
      number = {1},
      pages = {32-41},
      doi = {10.11648/j.ajlm.20200501.15},
      url = {https://doi.org/10.11648/j.ajlm.20200501.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20200501.15},
      abstract = {PIH accounts significantly for maternal and perinatal mortality, especially in rural communities. The sudden onset of PIH and the lack of definitive case management is worrisome. The study analysed differential leucocytes count on PIH outcomes. This is a case-control study of 40 PIH (8 GH, 16 PE and 16 EC) and 60 normotensive women who visited the Bolgatanga Regional Hospital, Ghana. Data on socio-demographics, clinical history and laboratory evaluations on blood and placental tissues were collected and analysed. Lymphocytes count was markedly increased in PIH women, while total leucocytes, neutrophils and NLR were significantly decreased. Lymphocytes count increased with severity of PIH (p=0.0037). A correlation (r=-0.9565, p<0.0001) between lymphocyte and neutrophil counts was observed among PIH subjects. Oxidative stress was more associated with PIH compared to controls. Stillbirths was associated with PIH mothers with high leucocytes count. NLR (AUC; 0.857, p<0.0001) and lymphocytes count (AUC; 0.822, p<0.0001) were optimal for prognosis of PIH. Wide variations in NLR and lymphocytes count during pregnancy necessitates urgent attention.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment
    AU  - Nafiu Amidu
    AU  - Benedict Boateng Antuamwine
    AU  - Martin Awe Akilla
    AU  - William Kwame Boakye Ansah Owiredu
    AU  - Otchere Addai-Mensah
    AU  - Peter Paul Dapare
    AU  - Eric Mishio Bawa
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    DO  - 10.11648/j.ajlm.20200501.15
    T2  - American Journal of Laboratory Medicine
    JF  - American Journal of Laboratory Medicine
    JO  - American Journal of Laboratory Medicine
    SP  - 32
    EP  - 41
    PB  - Science Publishing Group
    SN  - 2575-386X
    UR  - https://doi.org/10.11648/j.ajlm.20200501.15
    AB  - PIH accounts significantly for maternal and perinatal mortality, especially in rural communities. The sudden onset of PIH and the lack of definitive case management is worrisome. The study analysed differential leucocytes count on PIH outcomes. This is a case-control study of 40 PIH (8 GH, 16 PE and 16 EC) and 60 normotensive women who visited the Bolgatanga Regional Hospital, Ghana. Data on socio-demographics, clinical history and laboratory evaluations on blood and placental tissues were collected and analysed. Lymphocytes count was markedly increased in PIH women, while total leucocytes, neutrophils and NLR were significantly decreased. Lymphocytes count increased with severity of PIH (p=0.0037). A correlation (r=-0.9565, p<0.0001) between lymphocyte and neutrophil counts was observed among PIH subjects. Oxidative stress was more associated with PIH compared to controls. Stillbirths was associated with PIH mothers with high leucocytes count. NLR (AUC; 0.857, p<0.0001) and lymphocytes count (AUC; 0.822, p<0.0001) were optimal for prognosis of PIH. Wide variations in NLR and lymphocytes count during pregnancy necessitates urgent attention.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana

  • Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana

  • Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana

  • Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

  • Department of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

  • Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana

  • Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana

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