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Review of Liver Enzymes Abnormalities in Patients with SARS-CoV-2 Infection

Received: 10 November 2021     Accepted: 30 November 2021     Published: 8 January 2022
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Abstract

Background: Liver function derangements have been reported in COVID-19, but reported rates are variable. Treatment in intensive care units (ICU) has become a major challenge; therefore, early recognition of severe and critical cases is absolutely essential for timely triaging of patients. Objectives: to review incidence of acute liver injury in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Patients and methods: obtaining clinical records and laboratory results prospectively from one hundred patients with PCR-confirmed or radiography-confirmed COVID-19, who are admitted to the isolation wards and emergency departments of three different hospitals in Baghdad from 1st of December 2020 to 31st of March 2021. Results: The mean age group of study sample was (61.2±12.36) years, males formed 59%. GI manifestations were recorded in 47% of total cases, and were statistically correlated with disease severity (P value 0.001). Wide range of LFT abnormalities are found in patients with COVID-19, but none of which showed statistical significance in relation to disease severity. When LFT results were reviewed in relation to previous comorbidities, GGT was found to be statistically correlated with the underlying CLD (P value 0.001), and ALP with both underlying CLD and DM (P values <0.001 and 0.029, respectively) and even in the absence of underlying comorbidity (P value 0.006). Conclusion: Liver enzyme derangements are increasingly reported in patients with COVID-19, but are not necessarily correlate with disease severity. Cholestatic picture of liver enzyme derangement is a more commonly recorded manifestation.

Published in American Journal of Internal Medicine (Volume 10, Issue 1)
DOI 10.11648/j.ajim.20221001.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

COVID-19, SARS-CoV-2, Hepatitis, Liver Enzymes, Cholestasis

References
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[3] Nardo AD, Schneeweiss-Gleixner M, et al. Pathophysiological mechanisms of liver injury in COVID-19. Liver Int. 2021; 41: 20–32. (https://doi.org/10.1111/liv.14730).
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[12] Chai X, Hu L, Zhang Y, et al. Specific ACE2 expression in cholangiocytes amy cause liver damage after 2019-nCOV infection. bioRvix 2020: 7. (https://doi.org/10.1101/2020.02.03.941766).
[13] Alqahtani S, Schattenberg J. Liver Injury in COVID-19: The current evidence. United European Gastroenterology Journal. 2020; 8 (5): 509-19. (https://onlinelibrary.wiley.com/doi/10.1177/2050640620924157).
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  • APA Style

    Waseem F. Al Tameemi, Anas Habeeb Mohammed Matar Al-Sharqi. (2022). Review of Liver Enzymes Abnormalities in Patients with SARS-CoV-2 Infection. American Journal of Internal Medicine, 10(1), 1-7. https://doi.org/10.11648/j.ajim.20221001.11

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    ACS Style

    Waseem F. Al Tameemi; Anas Habeeb Mohammed Matar Al-Sharqi. Review of Liver Enzymes Abnormalities in Patients with SARS-CoV-2 Infection. Am. J. Intern. Med. 2022, 10(1), 1-7. doi: 10.11648/j.ajim.20221001.11

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    AMA Style

    Waseem F. Al Tameemi, Anas Habeeb Mohammed Matar Al-Sharqi. Review of Liver Enzymes Abnormalities in Patients with SARS-CoV-2 Infection. Am J Intern Med. 2022;10(1):1-7. doi: 10.11648/j.ajim.20221001.11

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  • @article{10.11648/j.ajim.20221001.11,
      author = {Waseem F. Al Tameemi and Anas Habeeb Mohammed Matar Al-Sharqi},
      title = {Review of Liver Enzymes Abnormalities in Patients with SARS-CoV-2 Infection},
      journal = {American Journal of Internal Medicine},
      volume = {10},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.ajim.20221001.11},
      url = {https://doi.org/10.11648/j.ajim.20221001.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20221001.11},
      abstract = {Background: Liver function derangements have been reported in COVID-19, but reported rates are variable. Treatment in intensive care units (ICU) has become a major challenge; therefore, early recognition of severe and critical cases is absolutely essential for timely triaging of patients. Objectives: to review incidence of acute liver injury in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Patients and methods: obtaining clinical records and laboratory results prospectively from one hundred patients with PCR-confirmed or radiography-confirmed COVID-19, who are admitted to the isolation wards and emergency departments of three different hospitals in Baghdad from 1st of December 2020 to 31st of March 2021. Results: The mean age group of study sample was (61.2±12.36) years, males formed 59%. GI manifestations were recorded in 47% of total cases, and were statistically correlated with disease severity (P value 0.001). Wide range of LFT abnormalities are found in patients with COVID-19, but none of which showed statistical significance in relation to disease severity. When LFT results were reviewed in relation to previous comorbidities, GGT was found to be statistically correlated with the underlying CLD (P value 0.001), and ALP with both underlying CLD and DM (P values Conclusion: Liver enzyme derangements are increasingly reported in patients with COVID-19, but are not necessarily correlate with disease severity. Cholestatic picture of liver enzyme derangement is a more commonly recorded manifestation.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Review of Liver Enzymes Abnormalities in Patients with SARS-CoV-2 Infection
    AU  - Waseem F. Al Tameemi
    AU  - Anas Habeeb Mohammed Matar Al-Sharqi
    Y1  - 2022/01/08
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ajim.20221001.11
    DO  - 10.11648/j.ajim.20221001.11
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 1
    EP  - 7
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20221001.11
    AB  - Background: Liver function derangements have been reported in COVID-19, but reported rates are variable. Treatment in intensive care units (ICU) has become a major challenge; therefore, early recognition of severe and critical cases is absolutely essential for timely triaging of patients. Objectives: to review incidence of acute liver injury in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Patients and methods: obtaining clinical records and laboratory results prospectively from one hundred patients with PCR-confirmed or radiography-confirmed COVID-19, who are admitted to the isolation wards and emergency departments of three different hospitals in Baghdad from 1st of December 2020 to 31st of March 2021. Results: The mean age group of study sample was (61.2±12.36) years, males formed 59%. GI manifestations were recorded in 47% of total cases, and were statistically correlated with disease severity (P value 0.001). Wide range of LFT abnormalities are found in patients with COVID-19, but none of which showed statistical significance in relation to disease severity. When LFT results were reviewed in relation to previous comorbidities, GGT was found to be statistically correlated with the underlying CLD (P value 0.001), and ALP with both underlying CLD and DM (P values Conclusion: Liver enzyme derangements are increasingly reported in patients with COVID-19, but are not necessarily correlate with disease severity. Cholestatic picture of liver enzyme derangement is a more commonly recorded manifestation.
    VL  - 10
    IS  - 1
    ER  - 

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Author Information
  • Department of Scholarships and Cultural Relations, Ministry of Higher Education and Scientific Research, Baghdad, Iraq

  • Al-Immamain Al-Kadhumein Medical City, Baghdad, Iraq

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