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Blood Count Under the Effect of Erythropoietin (EPO) in Patients with Chronic Hemodialysis

Received: 18 December 2021     Accepted: 5 January 2022     Published: 12 January 2022
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Abstract

One of the most common associated diseases in dialysis patients is anemia. The number of erythrocytes, hemoglobin and hematocrit is reduced in patients that suffer from anemia. These three measurement parameters represent the most important "red part" of the blood count. Due to renal insufficiency, patients on hemodialysis do not have enough erythropoietin, which healthy kidneys excreted, and is necessary for hematopoiesis. Erythropoietin (EPO) is the main regulator of the daily production of red blood cells. EPO that is execrated by peritubular capillary membrane cells in the kidneys circulates within plasma in order to interact with target cells in the bone marrow to maintain or stimulate erythropoiesis. The main purpose of the action of EPO is the formation of erythroid colonies. During observation of differences in the ordination of EPO in each group between men and women, there is no statistical significance evident in the incidence of anemia before and after therapy, as in p=0.70. The target concentration of hemoglobin, which must be constantly maintained in people with chronic renal anemia, is 110-120 g/l, while the target value of the number of red blood cells is 4-5x1012/l and the hematocrit value is 0.35-4.5 l/l, with a slight outflow depending on the gender of the patient. The final values of the participants in our study treated with epoetin alpha show higher values of hemoglobin, hematocrit and erythrocytes, while the average values recorded in participants treated with darbepoetin decreased.

Published in American Journal of Internal Medicine (Volume 10, Issue 1)
DOI 10.11648/j.ajim.20221001.12
Page(s) 8-12
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Erythropoietin, Hemodialysis, Erythrocytes, Hemoglobin, Hematocrit

References
[1] Prkačin I, Klarić D, Lovčić V, Galešić K, Ilić M, Raki S. (2016). Russian experience in efficacy and safety of anemia correction in predialysis patients. Acta Med Croatica, Vol. 70 (Suppl. 2) 14-18.
[2] Besarab A., Goodkin DA., Nissenson AR. (2008). Normal Hematocrit Cardiac Trial Authors. The normal hematocrit study--follow-up. N Engl J Med, 358: 433.
[3] Melissa E. (2014). Prevalence of Anemia in Chronic Kidney Disease in the United States. Clinical Infectious Diseases, 28 (5), 55-60.
[4] Winkelmayer W. (2015). Longer-term outcomes of darbepoetin alfa versus epoetin alfa in patients with ESRD initiating hemodialysis: a quasi-experimental cohort study. AJKD 66, 106-113.
[5] Farrington K. et al. (2016). Clinical Practice Guideline on management of older patients with chronic kidney disease stage 3b or higer. Pharmacology reports, 12 (4), 13-15.
[6] Kes P., Bašić N., Jukić I., Brunetta-Voronovic B. (2012) the Final stage of renal failure in the elderly. Acta med croatica, 66 (2): 22-36.
[7] Gregory M. (2007). Cronic renal failure. Complex Pediatric Hospital of Medicine, 693-699.
[8] Stauffer M., Tao F. (2014). Prevalence of Anemia in Chronic Kidney Disease in the United States. Plos one, 58-64.
[9] Bubić I., Prkačin I., Rački S. (2012). Efficiency and safety of cera in the treatment of anemia in predialysis patients, Croatian experience. Acta med croatica, 66 (2), 42-46.
[10] Palmer SC., Navaneethan SD., Craig JC., et al. (2010). Meta-analysis: erythropoiesis-stimulating agents in patients with chronic kidney disease. Ann Intern Med, 153: 23.
[11] Clement FM., Klarenbach S., Tonelli M., et al. (2009). The impact of selecting a high hemoglobin target level on health-related quality of life for patients with chronic kidney disease: a systematic review and meta-analysis. Arch Intern Med, 169: 1104.
[12] Coyne DW. (2012). The health-related quality of life was not improved by targeting higher hemoglobin in the Normal Hematocrit Trial. Kidney Int, 82: 235.
[13] Nissenson AR., Swan SK., Lindberg JS., et al. (2002). Randomized, controlled trial of darbepoetin alfa for the treatment of anemia in hemodialysis patients. Am J Kidney Dis, 40: 110.
[14] Tolman C., Richardson D., Bartlett C., Will E. (2005). Structured conversion from thrice weekly to weekly erythropoietic regimens using a computerized decision-support system: a randomized clinical study. J Am Soc Nephrol, 16: 1463.
[15] Weiner DE., Miskulin DC., Seefeld K. et al. (2007). Reducing versus discontinuing erythropoietin at high hemoglobin levels. J Am Soc Nephrol 2007, 18: 3184.
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  • APA Style

    Elvedin Osmanovic, Mersiha Cerkezovic, Almir Jagodic. (2022). Blood Count Under the Effect of Erythropoietin (EPO) in Patients with Chronic Hemodialysis. American Journal of Internal Medicine, 10(1), 8-12. https://doi.org/10.11648/j.ajim.20221001.12

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    ACS Style

    Elvedin Osmanovic; Mersiha Cerkezovic; Almir Jagodic. Blood Count Under the Effect of Erythropoietin (EPO) in Patients with Chronic Hemodialysis. Am. J. Intern. Med. 2022, 10(1), 8-12. doi: 10.11648/j.ajim.20221001.12

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    AMA Style

    Elvedin Osmanovic, Mersiha Cerkezovic, Almir Jagodic. Blood Count Under the Effect of Erythropoietin (EPO) in Patients with Chronic Hemodialysis. Am J Intern Med. 2022;10(1):8-12. doi: 10.11648/j.ajim.20221001.12

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  • @article{10.11648/j.ajim.20221001.12,
      author = {Elvedin Osmanovic and Mersiha Cerkezovic and Almir Jagodic},
      title = {Blood Count Under the Effect of Erythropoietin (EPO) in Patients with Chronic Hemodialysis},
      journal = {American Journal of Internal Medicine},
      volume = {10},
      number = {1},
      pages = {8-12},
      doi = {10.11648/j.ajim.20221001.12},
      url = {https://doi.org/10.11648/j.ajim.20221001.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20221001.12},
      abstract = {One of the most common associated diseases in dialysis patients is anemia. The number of erythrocytes, hemoglobin and hematocrit is reduced in patients that suffer from anemia. These three measurement parameters represent the most important "red part" of the blood count. Due to renal insufficiency, patients on hemodialysis do not have enough erythropoietin, which healthy kidneys excreted, and is necessary for hematopoiesis. Erythropoietin (EPO) is the main regulator of the daily production of red blood cells. EPO that is execrated by peritubular capillary membrane cells in the kidneys circulates within plasma in order to interact with target cells in the bone marrow to maintain or stimulate erythropoiesis. The main purpose of the action of EPO is the formation of erythroid colonies. During observation of differences in the ordination of EPO in each group between men and women, there is no statistical significance evident in the incidence of anemia before and after therapy, as in p=0.70. The target concentration of hemoglobin, which must be constantly maintained in people with chronic renal anemia, is 110-120 g/l, while the target value of the number of red blood cells is 4-5x1012/l and the hematocrit value is 0.35-4.5 l/l, with a slight outflow depending on the gender of the patient. The final values of the participants in our study treated with epoetin alpha show higher values of hemoglobin, hematocrit and erythrocytes, while the average values recorded in participants treated with darbepoetin decreased.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Blood Count Under the Effect of Erythropoietin (EPO) in Patients with Chronic Hemodialysis
    AU  - Elvedin Osmanovic
    AU  - Mersiha Cerkezovic
    AU  - Almir Jagodic
    Y1  - 2022/01/12
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ajim.20221001.12
    DO  - 10.11648/j.ajim.20221001.12
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 8
    EP  - 12
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20221001.12
    AB  - One of the most common associated diseases in dialysis patients is anemia. The number of erythrocytes, hemoglobin and hematocrit is reduced in patients that suffer from anemia. These three measurement parameters represent the most important "red part" of the blood count. Due to renal insufficiency, patients on hemodialysis do not have enough erythropoietin, which healthy kidneys excreted, and is necessary for hematopoiesis. Erythropoietin (EPO) is the main regulator of the daily production of red blood cells. EPO that is execrated by peritubular capillary membrane cells in the kidneys circulates within plasma in order to interact with target cells in the bone marrow to maintain or stimulate erythropoiesis. The main purpose of the action of EPO is the formation of erythroid colonies. During observation of differences in the ordination of EPO in each group between men and women, there is no statistical significance evident in the incidence of anemia before and after therapy, as in p=0.70. The target concentration of hemoglobin, which must be constantly maintained in people with chronic renal anemia, is 110-120 g/l, while the target value of the number of red blood cells is 4-5x1012/l and the hematocrit value is 0.35-4.5 l/l, with a slight outflow depending on the gender of the patient. The final values of the participants in our study treated with epoetin alpha show higher values of hemoglobin, hematocrit and erythrocytes, while the average values recorded in participants treated with darbepoetin decreased.
    VL  - 10
    IS  - 1
    ER  - 

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Author Information
  • Hemodialysis Center, Public Health Institution Health Centre Zivinice, Bosnia and Herzegovina

  • Hemodialysis Center, Public Health Institution Health Centre Zivinice, Bosnia and Herzegovina

  • Department of Physical Medicine and Rehabilitation, Public Health Institution Health Center Zivinice, Bosnia and Herzegovina

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