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Prescribing Pattern and Utilization of Antihypertensive Drugs and Blood Pressure Control in Adult Patients with Systemic Hypertension in a Rural Tertiary Hospital in Nigeria

Received: 14 December 2014     Accepted: 17 December 2014     Published: 23 December 2014
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Abstract

Background: Hypertension is a major public health concern globally and is associated with high morbidity and mortality in sub-Saharan Africa. Although antihypertensive therapy is effective in lowering blood pressure, a large proportion of patients do not have optimal blood pressure control. Aims: To describe the prescribing pattern and utilization of antihypertensive drugs and assess blood pressure control in a rural reference tertiary hospital in Nigeria. Methods: We conducted a cross-sectional study of 212 adult patients with hypertension attending the cardiology clinic of the Federal Medical Centre, Ido-Ekiti, Nigeria, between February 2012 and July 2012. Anthropometric, clinical and therapeutic data were collected using a pre-tested pro forma. Data analysis was done using SPSS 16.0 software (IBM, Chicago, Il, US). P value < 0.05 (two-sided test) was considered to be statistically significant. Results: We study 212 adults with hypertension, 48.1% of whom were male and the male-to-female ratio was 0.9. The mean age (± SD) of the patients was 61.5±15.1 years. Thirty two (15.1%), 95 (44.8%), 67 (31.6%) and 18 (8.5%) patients were on mono-, dual-, triple- and quadruple therapy respectively. Diuretics (84.9%) and calcium channel blockers (56.6%) were the most frequently used antihypertensive drugs. Blood pressure was controlled in only 45.3% of patients. Dual- and triple-therapy produced more patients with controlled blood pressure (dual-therapy, p=0.30; triple-therapy, p=0.11). Conclusions: Our study showed that diuretics were the most frequently prescribed class of antihypertensive drugs in our rural tertiary hospital as in many studies from urban centres in Nigeria and sub-Saharan Africa. Consistent with the global trend, the rate of controlled blood pressure among hypertensive patients was low, with combination therapy achieving control in more patients.

Published in American Journal of Internal Medicine (Volume 2, Issue 6)
DOI 10.11648/j.ajim.20140206.18
Page(s) 144-149
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Hypertension, Antihypertensive Drugs, Prescribing Pattern, Blood Pressure Control, Sub-Saharan Africa, Adherence

References
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Cite This Article
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    Olusegun Adesola Busari, Rotimi Oluyonbo, Abidemi Jude Fasae, Olusegun Emanuel Gabriel, Lawrence Majekodunmi Ayodele, et al. (2014). Prescribing Pattern and Utilization of Antihypertensive Drugs and Blood Pressure Control in Adult Patients with Systemic Hypertension in a Rural Tertiary Hospital in Nigeria. American Journal of Internal Medicine, 2(6), 144-149. https://doi.org/10.11648/j.ajim.20140206.18

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    Olusegun Adesola Busari; Rotimi Oluyonbo; Abidemi Jude Fasae; Olusegun Emanuel Gabriel; Lawrence Majekodunmi Ayodele, et al. Prescribing Pattern and Utilization of Antihypertensive Drugs and Blood Pressure Control in Adult Patients with Systemic Hypertension in a Rural Tertiary Hospital in Nigeria. Am. J. Intern. Med. 2014, 2(6), 144-149. doi: 10.11648/j.ajim.20140206.18

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    AMA Style

    Olusegun Adesola Busari, Rotimi Oluyonbo, Abidemi Jude Fasae, Olusegun Emanuel Gabriel, Lawrence Majekodunmi Ayodele, et al. Prescribing Pattern and Utilization of Antihypertensive Drugs and Blood Pressure Control in Adult Patients with Systemic Hypertension in a Rural Tertiary Hospital in Nigeria. Am J Intern Med. 2014;2(6):144-149. doi: 10.11648/j.ajim.20140206.18

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  • @article{10.11648/j.ajim.20140206.18,
      author = {Olusegun Adesola Busari and Rotimi Oluyonbo and Abidemi Jude Fasae and Olusegun Emanuel Gabriel and Lawrence Majekodunmi Ayodele and Segun Matthew Agboola and Adekunle OlatayoAdeoti},
      title = {Prescribing Pattern and Utilization of Antihypertensive Drugs and Blood Pressure Control in Adult Patients with Systemic Hypertension in a Rural Tertiary Hospital in Nigeria},
      journal = {American Journal of Internal Medicine},
      volume = {2},
      number = {6},
      pages = {144-149},
      doi = {10.11648/j.ajim.20140206.18},
      url = {https://doi.org/10.11648/j.ajim.20140206.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20140206.18},
      abstract = {Background: Hypertension is a major public health concern globally and is associated with high morbidity and mortality in sub-Saharan Africa. Although antihypertensive therapy is effective in lowering blood pressure, a large proportion of patients do not have optimal blood pressure control. Aims: To describe the prescribing pattern and utilization of antihypertensive drugs and assess blood pressure control in a rural reference tertiary hospital in Nigeria. Methods: We conducted a cross-sectional study of 212 adult patients with hypertension attending the cardiology clinic of the Federal Medical Centre, Ido-Ekiti, Nigeria, between February 2012 and July 2012. Anthropometric, clinical and therapeutic data were collected using a pre-tested pro forma. Data analysis was done using SPSS 16.0 software (IBM, Chicago, Il, US). P value < 0.05 (two-sided test) was considered to be statistically significant. Results: We study 212 adults with hypertension, 48.1% of whom were male and the male-to-female ratio was 0.9. The mean age (± SD) of the patients was 61.5±15.1 years. Thirty two (15.1%), 95 (44.8%), 67 (31.6%) and 18 (8.5%) patients were on mono-, dual-, triple- and quadruple therapy respectively. Diuretics (84.9%) and calcium channel blockers (56.6%) were the most frequently used antihypertensive drugs. Blood pressure was controlled in only 45.3% of patients. Dual- and triple-therapy produced more patients with controlled blood pressure (dual-therapy, p=0.30; triple-therapy, p=0.11). Conclusions: Our study showed that diuretics were the most frequently prescribed class of antihypertensive drugs in our rural tertiary hospital as in many studies from urban centres in Nigeria and sub-Saharan Africa. Consistent with the global trend, the rate of controlled blood pressure among hypertensive patients was low, with combination therapy achieving control in more patients.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Prescribing Pattern and Utilization of Antihypertensive Drugs and Blood Pressure Control in Adult Patients with Systemic Hypertension in a Rural Tertiary Hospital in Nigeria
    AU  - Olusegun Adesola Busari
    AU  - Rotimi Oluyonbo
    AU  - Abidemi Jude Fasae
    AU  - Olusegun Emanuel Gabriel
    AU  - Lawrence Majekodunmi Ayodele
    AU  - Segun Matthew Agboola
    AU  - Adekunle OlatayoAdeoti
    Y1  - 2014/12/23
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajim.20140206.18
    DO  - 10.11648/j.ajim.20140206.18
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 144
    EP  - 149
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20140206.18
    AB  - Background: Hypertension is a major public health concern globally and is associated with high morbidity and mortality in sub-Saharan Africa. Although antihypertensive therapy is effective in lowering blood pressure, a large proportion of patients do not have optimal blood pressure control. Aims: To describe the prescribing pattern and utilization of antihypertensive drugs and assess blood pressure control in a rural reference tertiary hospital in Nigeria. Methods: We conducted a cross-sectional study of 212 adult patients with hypertension attending the cardiology clinic of the Federal Medical Centre, Ido-Ekiti, Nigeria, between February 2012 and July 2012. Anthropometric, clinical and therapeutic data were collected using a pre-tested pro forma. Data analysis was done using SPSS 16.0 software (IBM, Chicago, Il, US). P value < 0.05 (two-sided test) was considered to be statistically significant. Results: We study 212 adults with hypertension, 48.1% of whom were male and the male-to-female ratio was 0.9. The mean age (± SD) of the patients was 61.5±15.1 years. Thirty two (15.1%), 95 (44.8%), 67 (31.6%) and 18 (8.5%) patients were on mono-, dual-, triple- and quadruple therapy respectively. Diuretics (84.9%) and calcium channel blockers (56.6%) were the most frequently used antihypertensive drugs. Blood pressure was controlled in only 45.3% of patients. Dual- and triple-therapy produced more patients with controlled blood pressure (dual-therapy, p=0.30; triple-therapy, p=0.11). Conclusions: Our study showed that diuretics were the most frequently prescribed class of antihypertensive drugs in our rural tertiary hospital as in many studies from urban centres in Nigeria and sub-Saharan Africa. Consistent with the global trend, the rate of controlled blood pressure among hypertensive patients was low, with combination therapy achieving control in more patients.
    VL  - 2
    IS  - 6
    ER  - 

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Author Information
  • Department of Internal Medicine, Federal Medical Centre, Ido-Ekiti, Nigeria

  • Department of Internal Medicine, Federal Medical Centre, Ido-Ekiti, Nigeria

  • Department of Internal Medicine, Federal Medical Centre, Ido-Ekiti, Nigeria

  • Department of Family Medicine, Federal Medical Centre, Ido-Ekiti, Nigeria

  • Department of Mental Health, Federal Medical Centre, Ido-Ekiti, Nigeria

  • Department of Family Medicine, Federal Medical Centre, Ido-Ekiti, Nigeria

  • Department of Internal Medicine, University Teaching Hospital, Ado-Ekiti, Nigeria

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