Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review

Kingsley John Orie; Remy Ukachukwu Duru; Raphael I-oro Ngochindo

doi:doi:10.11648/j.ajhc.20210702.11

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Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review

Kingsley John Orie, Remy Ukachukwu Duru, Raphael I-oro Ngochindo

Published in American Journal of Heterocyclic Chemistry (Volume 7, Issue 2)

Received: 19 June 2021 Accepted: 1 July 2021 Published: 9 July 2021

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Abstract

Aminopyridines are among the classes of heterocyclic compounds that have been extensively studied in the last few decades owing to their interesting biological activities. They exist in three isomeric forms: 2-aminopyridine, 3-aminopyridine and 4-aminopyridine. The diversity in their pharmacological activities has attracted the attention of many researchers to explore the reasons for their wide potential. This study examines recent advances related to the efficient procedure for synthesizing different types of aminopyridine derivatives, its coordination site with metals and biological activities using systematic literature review and content analysis. Other important concepts of aminopyridines discussed are basicity, electric hindrance as related to percentage yield of isomeric forms and spectra updates on the characterization of aminopyridines. The findings from this study also reveal the array of solvents used for purification processes; ideas on isomers that have not been used in the synthesis of aminopyridine derivatives and their respective biological activities. The significance of this study is on the various synthetic methods revealed, which may be helpful to the development of newer compounds with aminopyridines moieties that could offer high bioactivity and lesser toxicity.

Published in	American Journal of Heterocyclic Chemistry (Volume 7, Issue 2)
DOI	10.11648/j.ajhc.20210702.11
Page(s)	11-25
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Syntheses, Bioactivity, Aminopyridines, Basicity, Electric Hindrance

References

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Kingsley John Orie, Remy Ukachukwu Duru, Raphael I-oro Ngochindo. (2021). Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review. American Journal of Heterocyclic Chemistry, 7(2), 11-25. https://doi.org/10.11648/j.ajhc.20210702.11

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ACS Style

Kingsley John Orie; Remy Ukachukwu Duru; Raphael I-oro Ngochindo. Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review. Am. J. Heterocycl. Chem. 2021, 7(2), 11-25. doi: 10.11648/j.ajhc.20210702.11

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AMA Style

Kingsley John Orie, Remy Ukachukwu Duru, Raphael I-oro Ngochindo. Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review. Am J Heterocycl Chem. 2021;7(2):11-25. doi: 10.11648/j.ajhc.20210702.11

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@article{10.11648/j.ajhc.20210702.11,
  author = {Kingsley John Orie and Remy Ukachukwu Duru and Raphael I-oro Ngochindo},
  title = {Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review},
  journal = {American Journal of Heterocyclic Chemistry},
  volume = {7},
  number = {2},
  pages = {11-25},
  doi = {10.11648/j.ajhc.20210702.11},
  url = {https://doi.org/10.11648/j.ajhc.20210702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20210702.11},
  abstract = {Aminopyridines are among the classes of heterocyclic compounds that have been extensively studied in the last few decades owing to their interesting biological activities. They exist in three isomeric forms: 2-aminopyridine, 3-aminopyridine and 4-aminopyridine. The diversity in their pharmacological activities has attracted the attention of many researchers to explore the reasons for their wide potential. This study examines recent advances related to the efficient procedure for synthesizing different types of aminopyridine derivatives, its coordination site with metals and biological activities using systematic literature review and content analysis. Other important concepts of aminopyridines discussed are basicity, electric hindrance as related to percentage yield of isomeric forms and spectra updates on the characterization of aminopyridines. The findings from this study also reveal the array of solvents used for purification processes; ideas on isomers that have not been used in the synthesis of aminopyridine derivatives and their respective biological activities. The significance of this study is on the various synthetic methods revealed, which may be helpful to the development of newer compounds with aminopyridines moieties that could offer high bioactivity and lesser toxicity.},
 year = {2021}
}

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TY  - JOUR
T1  - Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review
AU  - Kingsley John Orie
AU  - Remy Ukachukwu Duru
AU  - Raphael I-oro Ngochindo
Y1  - 2021/07/09
PY  - 2021
N1  - https://doi.org/10.11648/j.ajhc.20210702.11
DO  - 10.11648/j.ajhc.20210702.11
T2  - American Journal of Heterocyclic Chemistry
JF  - American Journal of Heterocyclic Chemistry
JO  - American Journal of Heterocyclic Chemistry
SP  - 11
EP  - 25
PB  - Science Publishing Group
SN  - 2575-5722
UR  - https://doi.org/10.11648/j.ajhc.20210702.11
AB  - Aminopyridines are among the classes of heterocyclic compounds that have been extensively studied in the last few decades owing to their interesting biological activities. They exist in three isomeric forms: 2-aminopyridine, 3-aminopyridine and 4-aminopyridine. The diversity in their pharmacological activities has attracted the attention of many researchers to explore the reasons for their wide potential. This study examines recent advances related to the efficient procedure for synthesizing different types of aminopyridine derivatives, its coordination site with metals and biological activities using systematic literature review and content analysis. Other important concepts of aminopyridines discussed are basicity, electric hindrance as related to percentage yield of isomeric forms and spectra updates on the characterization of aminopyridines. The findings from this study also reveal the array of solvents used for purification processes; ideas on isomers that have not been used in the synthesis of aminopyridine derivatives and their respective biological activities. The significance of this study is on the various synthetic methods revealed, which may be helpful to the development of newer compounds with aminopyridines moieties that could offer high bioactivity and lesser toxicity.
VL  - 7
IS  - 2
ER  -

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Author Information

Kingsley John Orie

Department of Pure and Industrial Chemistry, University of Port Harcourt, Port Harcourt, Nigeria
Remy Ukachukwu Duru

Department of Pure and Industrial Chemistry, University of Port Harcourt, Port Harcourt, Nigeria
Raphael I-oro Ngochindo

Department of Pure and Industrial Chemistry, University of Port Harcourt, Port Harcourt, Nigeria

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APA Style

Kingsley John Orie, Remy Ukachukwu Duru, Raphael I-oro Ngochindo. (2021). Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review. American Journal of Heterocyclic Chemistry, 7(2), 11-25. https://doi.org/10.11648/j.ajhc.20210702.11

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ACS Style

Kingsley John Orie; Remy Ukachukwu Duru; Raphael I-oro Ngochindo. Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review. Am. J. Heterocycl. Chem. 2021, 7(2), 11-25. doi: 10.11648/j.ajhc.20210702.11

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AMA Style

Kingsley John Orie, Remy Ukachukwu Duru, Raphael I-oro Ngochindo. Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review. Am J Heterocycl Chem. 2021;7(2):11-25. doi: 10.11648/j.ajhc.20210702.11

Copy | Download

@article{10.11648/j.ajhc.20210702.11,
  author = {Kingsley John Orie and Remy Ukachukwu Duru and Raphael I-oro Ngochindo},
  title = {Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review},
  journal = {American Journal of Heterocyclic Chemistry},
  volume = {7},
  number = {2},
  pages = {11-25},
  doi = {10.11648/j.ajhc.20210702.11},
  url = {https://doi.org/10.11648/j.ajhc.20210702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20210702.11},
  abstract = {Aminopyridines are among the classes of heterocyclic compounds that have been extensively studied in the last few decades owing to their interesting biological activities. They exist in three isomeric forms: 2-aminopyridine, 3-aminopyridine and 4-aminopyridine. The diversity in their pharmacological activities has attracted the attention of many researchers to explore the reasons for their wide potential. This study examines recent advances related to the efficient procedure for synthesizing different types of aminopyridine derivatives, its coordination site with metals and biological activities using systematic literature review and content analysis. Other important concepts of aminopyridines discussed are basicity, electric hindrance as related to percentage yield of isomeric forms and spectra updates on the characterization of aminopyridines. The findings from this study also reveal the array of solvents used for purification processes; ideas on isomers that have not been used in the synthesis of aminopyridine derivatives and their respective biological activities. The significance of this study is on the various synthetic methods revealed, which may be helpful to the development of newer compounds with aminopyridines moieties that could offer high bioactivity and lesser toxicity.},
 year = {2021}
}

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TY  - JOUR
T1  - Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review
AU  - Kingsley John Orie
AU  - Remy Ukachukwu Duru
AU  - Raphael I-oro Ngochindo
Y1  - 2021/07/09
PY  - 2021
N1  - https://doi.org/10.11648/j.ajhc.20210702.11
DO  - 10.11648/j.ajhc.20210702.11
T2  - American Journal of Heterocyclic Chemistry
JF  - American Journal of Heterocyclic Chemistry
JO  - American Journal of Heterocyclic Chemistry
SP  - 11
EP  - 25
PB  - Science Publishing Group
SN  - 2575-5722
UR  - https://doi.org/10.11648/j.ajhc.20210702.11
AB  - Aminopyridines are among the classes of heterocyclic compounds that have been extensively studied in the last few decades owing to their interesting biological activities. They exist in three isomeric forms: 2-aminopyridine, 3-aminopyridine and 4-aminopyridine. The diversity in their pharmacological activities has attracted the attention of many researchers to explore the reasons for their wide potential. This study examines recent advances related to the efficient procedure for synthesizing different types of aminopyridine derivatives, its coordination site with metals and biological activities using systematic literature review and content analysis. Other important concepts of aminopyridines discussed are basicity, electric hindrance as related to percentage yield of isomeric forms and spectra updates on the characterization of aminopyridines. The findings from this study also reveal the array of solvents used for purification processes; ideas on isomers that have not been used in the synthesis of aminopyridine derivatives and their respective biological activities. The significance of this study is on the various synthetic methods revealed, which may be helpful to the development of newer compounds with aminopyridines moieties that could offer high bioactivity and lesser toxicity.
VL  - 7
IS  - 2
ER  -

Copy | Download