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Synthesis and Antimicrobial Activities Evaluation of New Spiro[4.5]dec-2-enes Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties

Received: 28 October 2016     Accepted: 10 February 2017     Published: 1 March 2017
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Abstract

A new series of 1,2,4,8-tetraazaspiro[4.5]dec-2-enes containing 1,2,4-triazole, piperidine and sulfonamide moieties have been synthesized from the reaction of 4-piperidone benzoylhydrazones having 1-methyl, 1-benzyl, and 1-isopropyl groups with appropriate nitrilimines. The microanalysis and spectral data (IR, 1H NMR, 13C NMR and MS) of the synthesized compounds are in full agreement with their molecular structure. The microbial features of the synthesized compounds were studied by a known method. Some of titled compounds exhibited significant antimicrobial activity on several strains of microbes.

Published in American Journal of Heterocyclic Chemistry (Volume 3, Issue 1)
DOI 10.11648/j.ajhc.20170301.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Nitrilimines, Piperidine, Sulfonamide, 1,2,4,8-tetraazaspiro[4.5]dec-2-ene

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Cite This Article
  • APA Style

    Hany Mahmoud Dalloul, Khaled A. El-nwairy, Ali Zayed Shorafa, Ahmed Sulyman Abu Samaha. (2017). Synthesis and Antimicrobial Activities Evaluation of New Spiro[4.5]dec-2-enes Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties. American Journal of Heterocyclic Chemistry, 3(1), 1-7. https://doi.org/10.11648/j.ajhc.20170301.11

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    ACS Style

    Hany Mahmoud Dalloul; Khaled A. El-nwairy; Ali Zayed Shorafa; Ahmed Sulyman Abu Samaha. Synthesis and Antimicrobial Activities Evaluation of New Spiro[4.5]dec-2-enes Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties. Am. J. Heterocycl. Chem. 2017, 3(1), 1-7. doi: 10.11648/j.ajhc.20170301.11

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    AMA Style

    Hany Mahmoud Dalloul, Khaled A. El-nwairy, Ali Zayed Shorafa, Ahmed Sulyman Abu Samaha. Synthesis and Antimicrobial Activities Evaluation of New Spiro[4.5]dec-2-enes Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties. Am J Heterocycl Chem. 2017;3(1):1-7. doi: 10.11648/j.ajhc.20170301.11

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  • @article{10.11648/j.ajhc.20170301.11,
      author = {Hany Mahmoud Dalloul and Khaled A. El-nwairy and Ali Zayed Shorafa and Ahmed Sulyman Abu Samaha},
      title = {Synthesis and Antimicrobial Activities Evaluation of New Spiro[4.5]dec-2-enes Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties},
      journal = {American Journal of Heterocyclic Chemistry},
      volume = {3},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.ajhc.20170301.11},
      url = {https://doi.org/10.11648/j.ajhc.20170301.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20170301.11},
      abstract = {A new series of 1,2,4,8-tetraazaspiro[4.5]dec-2-enes containing 1,2,4-triazole, piperidine and sulfonamide moieties have been synthesized from the reaction of 4-piperidone benzoylhydrazones having 1-methyl, 1-benzyl, and 1-isopropyl groups with appropriate nitrilimines. The microanalysis and spectral data (IR, 1H NMR, 13C NMR and MS) of the synthesized compounds are in full agreement with their molecular structure. The microbial features of the synthesized compounds were studied by a known method. Some of titled compounds exhibited significant antimicrobial activity on several strains of microbes.},
     year = {2017}
    }
    

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    T1  - Synthesis and Antimicrobial Activities Evaluation of New Spiro[4.5]dec-2-enes Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties
    AU  - Hany Mahmoud Dalloul
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    AU  - Ali Zayed Shorafa
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    N1  - https://doi.org/10.11648/j.ajhc.20170301.11
    DO  - 10.11648/j.ajhc.20170301.11
    T2  - American Journal of Heterocyclic Chemistry
    JF  - American Journal of Heterocyclic Chemistry
    JO  - American Journal of Heterocyclic Chemistry
    SP  - 1
    EP  - 7
    PB  - Science Publishing Group
    SN  - 2575-5722
    UR  - https://doi.org/10.11648/j.ajhc.20170301.11
    AB  - A new series of 1,2,4,8-tetraazaspiro[4.5]dec-2-enes containing 1,2,4-triazole, piperidine and sulfonamide moieties have been synthesized from the reaction of 4-piperidone benzoylhydrazones having 1-methyl, 1-benzyl, and 1-isopropyl groups with appropriate nitrilimines. The microanalysis and spectral data (IR, 1H NMR, 13C NMR and MS) of the synthesized compounds are in full agreement with their molecular structure. The microbial features of the synthesized compounds were studied by a known method. Some of titled compounds exhibited significant antimicrobial activity on several strains of microbes.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Department of Chemistry, Faculty of Applied Science, Alaqsa University of Gaza, Gaza Strip, Palestine

  • Ministry of Education & Higher Education, South Remal, Gaza, Palestine

  • Ministry of Education & Higher Education, South Remal, Gaza, Palestine

  • Department of Biology, Faculty of Applied Science, Alaqsa University, Gaza, Palestine

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