Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance

Ayuk Eugene Lakem; Nweke Cletus Mgadiugha; Ugwu Marigoretti Ogechukwu

doi:doi:10.11648/j.ajhc.20160201.15

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Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance

Ayuk Eugene Lakem, Nweke Cletus Mgadiugha, Ugwu Marigoretti Ogechukwu

Published in American Journal of Heterocyclic Chemistry (Volume 2, Issue 1)

Received: 12 July 2016 Accepted: 19 December 2016 Published: 10 January 2017

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Abstract

The synthesis and characterization of new complex monoaza and pentaaza angular phenothiazine derivatives is reported. The first derivative, 6,10-dichloro-17-azadibenzo[a,n]triphenodithiazin-5,11-dione 10 was obtained by a base-catalyzed reaction of 2,6-diaminopyridine-3,5-dithiol 5 and 2,3-dichloro-1,4-naphthaquinone 9, while the second derivative, 7,9,15,17-tetraamino-6,8,16,18,25-pentazadibenzo[a,n]di([1,4]benzothaizino[3,2-c,l])triphenodiathizine 11 was obtained by the reaction of two moles of 2, 4, 6-triaminopyrimidine-3-thiol 8 and one mole of compound 10 under the same reaction conditions. The assigned structures to the above synthesized compounds were done on the basis of spectroscopic analysis.

Published in	American Journal of Heterocyclic Chemistry (Volume 2, Issue 1)
DOI	10.11648/j.ajhc.20160201.15
Page(s)	26-31
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Monoaza, Pentaaza, Triphenodiathiazine, Triaminopyrimidine-3-Thiol, Phenothiazine

References

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[2]	Sinha Shweta; Pandeja S. N; Verma Anopam; Yadav Deepika. Synthesis and biological activity of phenothiazine derivatives; Int. J Research in Ayurveda& Pharm. 2 (4), 1130-1137, 2011.
[3]	Upendra Kumar; Kushwaha Yashovardhan; Sudhir Kumar Bhati and Asohok Kumar. Synthesis of new 10-substituted phenothiazines as Inflammatory and Analgesic Agents; Int. J. Pharm and Bio. Science, 1 (3), 1-10, 2010.
[4]	Okafor C. O. Chemistry and applications of angular phenothiazines. Dyes and Pigments, 7 (4), 249-287, 1986.
[5]	Massie S. P. The Chemistry of Phenothiazines. Chem. Rev, 54; 797-833, 1954.
[6]	Massie S. P; Kadaba P. K; Ring Derivatives of Phenothiazines. The Synthesis of 1-substituted phenothiazines by Thionation; J. Org. Chem. 21: 347-348, 1956.
[7]	Okafor C. O; Okerulu I. O; Okeke S. I; Vat dyes from new heterocyclic ring systems. Dyes and Pigments, 8, 11–24, 1987.
[8]	B. E. Ezema, C. O. Okafor, C. G. Ezema and A. E. Onoabedje. Synthesis of new diaza angular and tetraazacomplex phenothiazine rings. Chemical and Processing Engineering Research, 3, 40-47, 2012.
[9]	U. C. Okoro and B. E. Ezema; Synthesis of new non-linear diazaphenothiazine ring system. Int. Jour. Chem. 16, (2), 115-120, 2006.
[10]	Okoro U. C; The first analogues of dibenzotriphenodithiazine ring systems. Ind. J. Chem. 30B (118), 22-24, 1991.
[11]	B. E. Ezema; C. E. Ezema; D. I. Ugwu; Synthesis of a new and first triazadibenzo[a,n] triphenodithiazine. Chemical and Processing Engieering Research, 8, 35-41, 2013.
[12]	U. C. Okoro and A. O. Ijeoma; Synthesis of new non-linear polycyclic diazaphenothiazine ring system. International Jour of Chem. 16, (4), 245-250, 2006.
[13]	Okafor C. O; Anew type of angular phenothiazine ring system. Tetrahedron, 42 (10) 22771-80, 1986.
[14]	Okoro U. C., Synthesis of a new branched benzoxazinoazaphenothiazine ring system. Ind. J. Chem. 30B, (18), 22-24, 1991.

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APA Style

Ayuk Eugene Lakem, Nweke Cletus Mgadiugha, Ugwu Marigoretti Ogechukwu. (2017). Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance. American Journal of Heterocyclic Chemistry, 2(1), 26-31. https://doi.org/10.11648/j.ajhc.20160201.15

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ACS Style

Ayuk Eugene Lakem; Nweke Cletus Mgadiugha; Ugwu Marigoretti Ogechukwu. Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance. Am. J. Heterocycl. Chem. 2017, 2(1), 26-31. doi: 10.11648/j.ajhc.20160201.15

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AMA Style

Ayuk Eugene Lakem, Nweke Cletus Mgadiugha, Ugwu Marigoretti Ogechukwu. Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance. Am J Heterocycl Chem. 2017;2(1):26-31. doi: 10.11648/j.ajhc.20160201.15

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@article{10.11648/j.ajhc.20160201.15,
  author = {Ayuk Eugene Lakem and Nweke Cletus Mgadiugha and Ugwu Marigoretti Ogechukwu},
  title = {Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance},
  journal = {American Journal of Heterocyclic Chemistry},
  volume = {2},
  number = {1},
  pages = {26-31},
  doi = {10.11648/j.ajhc.20160201.15},
  url = {https://doi.org/10.11648/j.ajhc.20160201.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20160201.15},
  abstract = {The synthesis and characterization of new complex monoaza and pentaaza angular phenothiazine derivatives is reported. The first derivative, 6,10-dichloro-17-azadibenzo[a,n]triphenodithiazin-5,11-dione 10 was obtained by a base-catalyzed reaction of 2,6-diaminopyridine-3,5-dithiol 5 and 2,3-dichloro-1,4-naphthaquinone 9, while the second derivative, 7,9,15,17-tetraamino-6,8,16,18,25-pentazadibenzo[a,n]di([1,4]benzothaizino[3,2-c,l])triphenodiathizine 11 was obtained by the reaction of two moles of 2, 4, 6-triaminopyrimidine-3-thiol 8 and one mole of compound 10 under the same reaction conditions. The assigned structures to the above synthesized compounds were done on the basis of spectroscopic analysis.},
 year = {2017}
}

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TY  - JOUR
T1  - Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance
AU  - Ayuk Eugene Lakem
AU  - Nweke Cletus Mgadiugha
AU  - Ugwu Marigoretti Ogechukwu
Y1  - 2017/01/10
PY  - 2017
N1  - https://doi.org/10.11648/j.ajhc.20160201.15
DO  - 10.11648/j.ajhc.20160201.15
T2  - American Journal of Heterocyclic Chemistry
JF  - American Journal of Heterocyclic Chemistry
JO  - American Journal of Heterocyclic Chemistry
SP  - 26
EP  - 31
PB  - Science Publishing Group
SN  - 2575-5722
UR  - https://doi.org/10.11648/j.ajhc.20160201.15
AB  - The synthesis and characterization of new complex monoaza and pentaaza angular phenothiazine derivatives is reported. The first derivative, 6,10-dichloro-17-azadibenzo[a,n]triphenodithiazin-5,11-dione 10 was obtained by a base-catalyzed reaction of 2,6-diaminopyridine-3,5-dithiol 5 and 2,3-dichloro-1,4-naphthaquinone 9, while the second derivative, 7,9,15,17-tetraamino-6,8,16,18,25-pentazadibenzo[a,n]di([1,4]benzothaizino[3,2-c,l])triphenodiathizine 11 was obtained by the reaction of two moles of 2, 4, 6-triaminopyrimidine-3-thiol 8 and one mole of compound 10 under the same reaction conditions. The assigned structures to the above synthesized compounds were done on the basis of spectroscopic analysis.
VL  - 2
IS  - 1
ER  -

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Author Information

Ayuk Eugene Lakem

Industrial Chemistry Unit, Chemical Sciences Department, Godfrey Okoye University, Ugwuomu-Nike, Enugu, Nigeria
Nweke Cletus Mgadiugha

Industrial Chemistry Unit, Chemical Sciences Department, Godfrey Okoye University, Ugwuomu-Nike, Enugu, Nigeria
Ugwu Marigoretti Ogechukwu

Industrial Chemistry Unit, Chemical Sciences Department, Godfrey Okoye University, Ugwuomu-Nike, Enugu, Nigeria

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Plain Text BibTeX RIS

APA Style

Ayuk Eugene Lakem, Nweke Cletus Mgadiugha, Ugwu Marigoretti Ogechukwu. (2017). Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance. American Journal of Heterocyclic Chemistry, 2(1), 26-31. https://doi.org/10.11648/j.ajhc.20160201.15

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ACS Style

Ayuk Eugene Lakem; Nweke Cletus Mgadiugha; Ugwu Marigoretti Ogechukwu. Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance. Am. J. Heterocycl. Chem. 2017, 2(1), 26-31. doi: 10.11648/j.ajhc.20160201.15

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AMA Style

Ayuk Eugene Lakem, Nweke Cletus Mgadiugha, Ugwu Marigoretti Ogechukwu. Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance. Am J Heterocycl Chem. 2017;2(1):26-31. doi: 10.11648/j.ajhc.20160201.15

Copy | Download

@article{10.11648/j.ajhc.20160201.15,
  author = {Ayuk Eugene Lakem and Nweke Cletus Mgadiugha and Ugwu Marigoretti Ogechukwu},
  title = {Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance},
  journal = {American Journal of Heterocyclic Chemistry},
  volume = {2},
  number = {1},
  pages = {26-31},
  doi = {10.11648/j.ajhc.20160201.15},
  url = {https://doi.org/10.11648/j.ajhc.20160201.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20160201.15},
  abstract = {The synthesis and characterization of new complex monoaza and pentaaza angular phenothiazine derivatives is reported. The first derivative, 6,10-dichloro-17-azadibenzo[a,n]triphenodithiazin-5,11-dione 10 was obtained by a base-catalyzed reaction of 2,6-diaminopyridine-3,5-dithiol 5 and 2,3-dichloro-1,4-naphthaquinone 9, while the second derivative, 7,9,15,17-tetraamino-6,8,16,18,25-pentazadibenzo[a,n]di([1,4]benzothaizino[3,2-c,l])triphenodiathizine 11 was obtained by the reaction of two moles of 2, 4, 6-triaminopyrimidine-3-thiol 8 and one mole of compound 10 under the same reaction conditions. The assigned structures to the above synthesized compounds were done on the basis of spectroscopic analysis.},
 year = {2017}
}

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TY  - JOUR
T1  - Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance
AU  - Ayuk Eugene Lakem
AU  - Nweke Cletus Mgadiugha
AU  - Ugwu Marigoretti Ogechukwu
Y1  - 2017/01/10
PY  - 2017
N1  - https://doi.org/10.11648/j.ajhc.20160201.15
DO  - 10.11648/j.ajhc.20160201.15
T2  - American Journal of Heterocyclic Chemistry
JF  - American Journal of Heterocyclic Chemistry
JO  - American Journal of Heterocyclic Chemistry
SP  - 26
EP  - 31
PB  - Science Publishing Group
SN  - 2575-5722
UR  - https://doi.org/10.11648/j.ajhc.20160201.15
AB  - The synthesis and characterization of new complex monoaza and pentaaza angular phenothiazine derivatives is reported. The first derivative, 6,10-dichloro-17-azadibenzo[a,n]triphenodithiazin-5,11-dione 10 was obtained by a base-catalyzed reaction of 2,6-diaminopyridine-3,5-dithiol 5 and 2,3-dichloro-1,4-naphthaquinone 9, while the second derivative, 7,9,15,17-tetraamino-6,8,16,18,25-pentazadibenzo[a,n]di([1,4]benzothaizino[3,2-c,l])triphenodiathizine 11 was obtained by the reaction of two moles of 2, 4, 6-triaminopyrimidine-3-thiol 8 and one mole of compound 10 under the same reaction conditions. The assigned structures to the above synthesized compounds were done on the basis of spectroscopic analysis.
VL  - 2
IS  - 1
ER  -

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