A new series of pyrimidine -2-thione derivatives were synthesized via two routes and designated as antifolate. The heterocyclic ring was prepared by direct reaction of benzoyl acetone with thiosemicarbiazide in acidic medium. Also, the pyrimidine-2-thione ring reacts with p-aminobenzoic acid to form 4-amino-N-(4-methyl-6-phenyl)-2-thioxypyrimidine 1[2H] –yl benzamide. The second route synthesis 5-[{4-methyl-6-phenyl-2-thioxo pyridine-1-yl amino}-4-(4-methyl phenylsulfonamido)-5-oxobenzoyl] pentanoic acid. All structures were elucidate by their physical & spectroscopic data FTIR, 1H &13C NMR.
| Published in | American Journal of Heterocyclic Chemistry (Volume 2, Issue 1) |
| DOI | 10.11648/j.ajhc.20160201.12 |
| Page(s) | 8-12 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Antifolate, P-aminobenzoic Acid, Pyrimidine, NMR
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APA Style
Moayed J. Mohammed, Ahmed Kh. Ahmed, Faris T. Abachi. (2016). Spectroscopic Identification and Synthesis of Derivatives of Pyrimidine 2- Thione Via Two Different Spacers. American Journal of Heterocyclic Chemistry, 2(1), 8-12. https://doi.org/10.11648/j.ajhc.20160201.12
ACS Style
Moayed J. Mohammed; Ahmed Kh. Ahmed; Faris T. Abachi. Spectroscopic Identification and Synthesis of Derivatives of Pyrimidine 2- Thione Via Two Different Spacers. Am. J. Heterocycl. Chem. 2016, 2(1), 8-12. doi: 10.11648/j.ajhc.20160201.12
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Download@article{10.11648/j.ajhc.20160201.12,
author = {Moayed J. Mohammed and Ahmed Kh. Ahmed and Faris T. Abachi},
title = {Spectroscopic Identification and Synthesis of Derivatives of Pyrimidine 2- Thione Via Two Different Spacers},
journal = {American Journal of Heterocyclic Chemistry},
volume = {2},
number = {1},
pages = {8-12},
doi = {10.11648/j.ajhc.20160201.12},
url = {https://doi.org/10.11648/j.ajhc.20160201.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20160201.12},
abstract = {A new series of pyrimidine -2-thione derivatives were synthesized via two routes and designated as antifolate. The heterocyclic ring was prepared by direct reaction of benzoyl acetone with thiosemicarbiazide in acidic medium. Also, the pyrimidine-2-thione ring reacts with p-aminobenzoic acid to form 4-amino-N-(4-methyl-6-phenyl)-2-thioxypyrimidine 1[2H] –yl benzamide. The second route synthesis 5-[{4-methyl-6-phenyl-2-thioxo pyridine-1-yl amino}-4-(4-methyl phenylsulfonamido)-5-oxobenzoyl] pentanoic acid. All structures were elucidate by their physical & spectroscopic data FTIR, 1H &13C NMR.},
year = {2016}
}
TY - JOUR
T1 - Spectroscopic Identification and Synthesis of Derivatives of Pyrimidine 2- Thione Via Two Different Spacers
AU - Moayed J. Mohammed
AU - Ahmed Kh. Ahmed
AU - Faris T. Abachi
Y1 - 2016/12/10
PY - 2016
N1 - https://doi.org/10.11648/j.ajhc.20160201.12
DO - 10.11648/j.ajhc.20160201.12
T2 - American Journal of Heterocyclic Chemistry
JF - American Journal of Heterocyclic Chemistry
JO - American Journal of Heterocyclic Chemistry
SP - 8
EP - 12
PB - Science Publishing Group
SN - 2575-5722
UR - https://doi.org/10.11648/j.ajhc.20160201.12
AB - A new series of pyrimidine -2-thione derivatives were synthesized via two routes and designated as antifolate. The heterocyclic ring was prepared by direct reaction of benzoyl acetone with thiosemicarbiazide in acidic medium. Also, the pyrimidine-2-thione ring reacts with p-aminobenzoic acid to form 4-amino-N-(4-methyl-6-phenyl)-2-thioxypyrimidine 1[2H] –yl benzamide. The second route synthesis 5-[{4-methyl-6-phenyl-2-thioxo pyridine-1-yl amino}-4-(4-methyl phenylsulfonamido)-5-oxobenzoyl] pentanoic acid. All structures were elucidate by their physical & spectroscopic data FTIR, 1H &13C NMR.
VL - 2
IS - 1
ER -
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