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Papillary Tumor of the Pineal Region: A Case Report and Literature Review

Received: 7 February 2023     Accepted: 1 March 2023     Published: 20 March 2023
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Abstract

Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented with intermittent dizziness and headache with vomiting for more than 2 months. The imaging revealed a mass in the region of the pineal region with obstructive hydrocephalus. After the hospitalization, the patient underwent a microscopic excision of the pineal mass, and the tissue was sent for histopathological examination and available immunohistochemical tests, which resulted in a definitive diagnosis of a papillary tumor of the pineal region. He had undergone several radiation treatments during his hospitalization and remained recurrence-free until the latest follow-up visit. This article highlights the similarities between this case and the PTPR described in WHO 2021 in terms of clinical presentation, imaging, and histopathological features. Therefore, this case report completes the sample database of PTPRs. By reviewing the literature related to PTPRs, we hope that this report will be helpful to improve the understanding of clinicians and pathologists about this rare tumor. However, more relevant studies are needed to clarify the pathogenesis, prognosis, and optimal treatment options to achieve early diagnosis, early treatment, and improved prognosis.

Published in American Journal of Clinical and Experimental Medicine (Volume 11, Issue 2)
DOI 10.11648/j.ajcem.20231102.11
Page(s) 29-32
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Papillary Tumor of the Pineal Region, PTPR, Pineal Parenchymal Tumor, Diagnosis

References
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[4] Jouvet A, Fauchon F, Liberski P, et al. Papillary tumor of the pineal region. Am J Surg Pathol. 2003; 27 (4): 505-512. doi: 10.1097/00000478-200304000-00011.
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[7] Goschzik T, Gessi M, Denkhaus D, et al. PTEN mutations and activation of the PI3K/Akt/mTOR signaling pathway in papillary tumors of the pineal region. J Neuropathol Exp Neurol. 2014; 73 (8): 747-751. doi: 10.1097/nen.0000000000000093.
[8] Hasselblatt M, Blümcke I, Jeibmann A, et al. Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region. Neuropathol Appl Neurobiol. 2006; 32 (3): 278-283. doi: 10.1111/j.1365-2990.2006.00723.x.
[9] Assi HI, Kakati RT, Berro J, et al. PTEN R130Q Papillary Tumor of the Pineal Region (PTPR) with Chromosome 10 Loss Successfully Treated with Everolimus: A Case Report. Curr Oncol. 2021; 28 (2): 1274-1279. doi: 10.3390/curroncol28020121.
[10] Fèvre Montange M, Vasiljevic A, Champier J, et al. Papillary tumor of the pineal region: Histopathological characterization and review of the literature. Neurochirurgie. 2015; 61 (2-3): 138-142. doi: 10.1016/j.neuchi.2013.04.011.
[11] Fauchon F, Hasselblatt M, Jouvet A, et al. Role of surgery, radiotherapy and chemotherapy in papillary tumors of the pineal region: a multicenter study. J Neurooncol. 2013; 112 (2): 223-231. doi: 10.1007/s11060-013-1050-5.
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[14] Lechapt-Zalcman E, Chapon F, Guillamo JS, et al. Long-term clinicopathological observations on a papillary tumour of the pineal region. Neuropathol Appl Neurobiol. 2011; 37 (4): 431-435. doi: 10.1111/j.1365-2990.2010.01133.x.
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Cite This Article
  • APA Style

    Peng Lilin, Zhong Lijuan, Yang Bo, Lu Yuanzhi. (2023). Papillary Tumor of the Pineal Region: A Case Report and Literature Review. American Journal of Clinical and Experimental Medicine, 11(2), 29-32. https://doi.org/10.11648/j.ajcem.20231102.11

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    ACS Style

    Peng Lilin; Zhong Lijuan; Yang Bo; Lu Yuanzhi. Papillary Tumor of the Pineal Region: A Case Report and Literature Review. Am. J. Clin. Exp. Med. 2023, 11(2), 29-32. doi: 10.11648/j.ajcem.20231102.11

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    AMA Style

    Peng Lilin, Zhong Lijuan, Yang Bo, Lu Yuanzhi. Papillary Tumor of the Pineal Region: A Case Report and Literature Review. Am J Clin Exp Med. 2023;11(2):29-32. doi: 10.11648/j.ajcem.20231102.11

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  • @article{10.11648/j.ajcem.20231102.11,
      author = {Peng Lilin and Zhong Lijuan and Yang Bo and Lu Yuanzhi},
      title = {Papillary Tumor of the Pineal Region: A Case Report and Literature Review},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {11},
      number = {2},
      pages = {29-32},
      doi = {10.11648/j.ajcem.20231102.11},
      url = {https://doi.org/10.11648/j.ajcem.20231102.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20231102.11},
      abstract = {Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented with intermittent dizziness and headache with vomiting for more than 2 months. The imaging revealed a mass in the region of the pineal region with obstructive hydrocephalus. After the hospitalization, the patient underwent a microscopic excision of the pineal mass, and the tissue was sent for histopathological examination and available immunohistochemical tests, which resulted in a definitive diagnosis of a papillary tumor of the pineal region. He had undergone several radiation treatments during his hospitalization and remained recurrence-free until the latest follow-up visit. This article highlights the similarities between this case and the PTPR described in WHO 2021 in terms of clinical presentation, imaging, and histopathological features. Therefore, this case report completes the sample database of PTPRs. By reviewing the literature related to PTPRs, we hope that this report will be helpful to improve the understanding of clinicians and pathologists about this rare tumor. However, more relevant studies are needed to clarify the pathogenesis, prognosis, and optimal treatment options to achieve early diagnosis, early treatment, and improved prognosis.},
     year = {2023}
    }
    

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    T1  - Papillary Tumor of the Pineal Region: A Case Report and Literature Review
    AU  - Peng Lilin
    AU  - Zhong Lijuan
    AU  - Yang Bo
    AU  - Lu Yuanzhi
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    DO  - 10.11648/j.ajcem.20231102.11
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
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    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20231102.11
    AB  - Pineal tumors of the pineal region (PTPR) are rare neuroepithelial tumors of the central nervous system, and their clinical features often lack specificity, so it is always difficult to make a definite diagnosis before surgery, and the treatment is mainly based on complete surgical resection. We report the case of a 21-year-old male who presented with intermittent dizziness and headache with vomiting for more than 2 months. The imaging revealed a mass in the region of the pineal region with obstructive hydrocephalus. After the hospitalization, the patient underwent a microscopic excision of the pineal mass, and the tissue was sent for histopathological examination and available immunohistochemical tests, which resulted in a definitive diagnosis of a papillary tumor of the pineal region. He had undergone several radiation treatments during his hospitalization and remained recurrence-free until the latest follow-up visit. This article highlights the similarities between this case and the PTPR described in WHO 2021 in terms of clinical presentation, imaging, and histopathological features. Therefore, this case report completes the sample database of PTPRs. By reviewing the literature related to PTPRs, we hope that this report will be helpful to improve the understanding of clinicians and pathologists about this rare tumor. However, more relevant studies are needed to clarify the pathogenesis, prognosis, and optimal treatment options to achieve early diagnosis, early treatment, and improved prognosis.
    VL  - 11
    IS  - 2
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Author Information
  • Department of Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pathology, First Affiliated Hospital of Jinan University, Guangzhou, China

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