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The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma

Received: 15 November 2021     Accepted: 6 December 2021     Published: 7 December 2021
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Abstract

Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: To explore the expression and clinical significance of interleukin-4 (IL-4) and interleukin-13 (IL-13) in the tissues and serum of patients with papillary thyroid carcinoma (PTC). Method: 120 cases of PTC patients were randomly selected as the experimental group, who underwent radical mastectomy at the Thyroid and Breast Surgery Department of Cangzhou Central Hospital from January 2018 to April 2019, and the PTC tissues and their adjacent tissues and serum samples were collected. 120 healthy people were matched 1:1 as the control group in the hospital physical examination center during the same period, according to the gender, age and body mass index of the experimental group, and serum samples were collected. The immunohisto chemical SP method is adopted to test the expression of IL-4 and IL-13 in the tissues, and the ELISA is adopted to test the serum levels of IL-4 and IL-13. Analyze the relationship between IL-4 and IL-13 expression and clinicopathological characteristics in PTC. Result: It was significantly higher with the positive expression rate of IL-4 and IL-13 in PTC tissues than that in adjacent tissues (P<0.05), and it was a significant positive correlation between IL-4 and IL-13 expressed in PTC tissues (r=0.375, P=0.002); It was significantly higher in the serum levels of IL-4 and IL-13 in PTC patients, than that in healthy subjects (P<0.05), and it was a significant positive correlation between IL-4 and IL-13 expressed in the serum of PTC patients (r=0.381, P<0.01); The expression of IL-4 and IL-13 was related to the maximum tumor diameter, TNM stage, degree of differentiation, and lymphatic metastasis in PTC (P<0.05). Conclusion: IL-4 and IL-13 were highly expressed in PTC, and the expression level may become a reference indicator for predicting the occurrence and development of PTC.

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6)
DOI 10.11648/j.ajcem.20210906.15
Page(s) 215-222
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Papillary Thyroid Carcinoma, Interleukin-4, Interleukin-13, Clinical Significance

References
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Cite This Article
  • APA Style

    Ying Li, Feng Zhou, Chao Shen, Yi Su, Yanxia Li, et al. (2021). The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma. American Journal of Clinical and Experimental Medicine, 9(6), 215-222. https://doi.org/10.11648/j.ajcem.20210906.15

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    ACS Style

    Ying Li; Feng Zhou; Chao Shen; Yi Su; Yanxia Li, et al. The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma. Am. J. Clin. Exp. Med. 2021, 9(6), 215-222. doi: 10.11648/j.ajcem.20210906.15

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    AMA Style

    Ying Li, Feng Zhou, Chao Shen, Yi Su, Yanxia Li, et al. The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma. Am J Clin Exp Med. 2021;9(6):215-222. doi: 10.11648/j.ajcem.20210906.15

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  • @article{10.11648/j.ajcem.20210906.15,
      author = {Ying Li and Feng Zhou and Chao Shen and Yi Su and Yanxia Li and Cuicui Wang and Ruixia Yan and Guiran Yang and Zhenjiang Hou},
      title = {The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {9},
      number = {6},
      pages = {215-222},
      doi = {10.11648/j.ajcem.20210906.15},
      url = {https://doi.org/10.11648/j.ajcem.20210906.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.15},
      abstract = {Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: To explore the expression and clinical significance of interleukin-4 (IL-4) and interleukin-13 (IL-13) in the tissues and serum of patients with papillary thyroid carcinoma (PTC). Method: 120 cases of PTC patients were randomly selected as the experimental group, who underwent radical mastectomy at the Thyroid and Breast Surgery Department of Cangzhou Central Hospital from January 2018 to April 2019, and the PTC tissues and their adjacent tissues and serum samples were collected. 120 healthy people were matched 1:1 as the control group in the hospital physical examination center during the same period, according to the gender, age and body mass index of the experimental group, and serum samples were collected. The immunohisto chemical SP method is adopted to test the expression of IL-4 and IL-13 in the tissues, and the ELISA is adopted to test the serum levels of IL-4 and IL-13. Analyze the relationship between IL-4 and IL-13 expression and clinicopathological characteristics in PTC. Result: It was significantly higher with the positive expression rate of IL-4 and IL-13 in PTC tissues than that in adjacent tissues (PConclusion: IL-4 and IL-13 were highly expressed in PTC, and the expression level may become a reference indicator for predicting the occurrence and development of PTC.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma
    AU  - Ying Li
    AU  - Feng Zhou
    AU  - Chao Shen
    AU  - Yi Su
    AU  - Yanxia Li
    AU  - Cuicui Wang
    AU  - Ruixia Yan
    AU  - Guiran Yang
    AU  - Zhenjiang Hou
    Y1  - 2021/12/07
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajcem.20210906.15
    DO  - 10.11648/j.ajcem.20210906.15
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 215
    EP  - 222
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20210906.15
    AB  - Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: To explore the expression and clinical significance of interleukin-4 (IL-4) and interleukin-13 (IL-13) in the tissues and serum of patients with papillary thyroid carcinoma (PTC). Method: 120 cases of PTC patients were randomly selected as the experimental group, who underwent radical mastectomy at the Thyroid and Breast Surgery Department of Cangzhou Central Hospital from January 2018 to April 2019, and the PTC tissues and their adjacent tissues and serum samples were collected. 120 healthy people were matched 1:1 as the control group in the hospital physical examination center during the same period, according to the gender, age and body mass index of the experimental group, and serum samples were collected. The immunohisto chemical SP method is adopted to test the expression of IL-4 and IL-13 in the tissues, and the ELISA is adopted to test the serum levels of IL-4 and IL-13. Analyze the relationship between IL-4 and IL-13 expression and clinicopathological characteristics in PTC. Result: It was significantly higher with the positive expression rate of IL-4 and IL-13 in PTC tissues than that in adjacent tissues (PConclusion: IL-4 and IL-13 were highly expressed in PTC, and the expression level may become a reference indicator for predicting the occurrence and development of PTC.
    VL  - 9
    IS  - 6
    ER  - 

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Author Information
  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Thyroid and Breast Surgical Department, People's Hospital of Nanpi County, Cangzhou, China

  • Department of Rheumatology and Immunology, Cangzhou Central Hospital, Cangzhou, China

  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Department of Medical Technology, Cangzhou Medical College, Cangzhou, China

  • Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

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