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Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats

Received: 2 November 2021     Accepted: 25 November 2021     Published: 7 December 2021
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Abstract

Objectives: The morbidity rate of hypothyroidism is relatively high, the features of which are delitescent invasion, long course, untypical symptoms, great harm, etc. To intervene and cure hypothyroidism by traditional Chinese medicine could palliate untoward reaction of Western medicine, relieve symptoms of patients and enhance immunity. Astragalus mongholicus is frequently used as clinical traditional Chinese medicine. Reported by some literatures, compositions of Astragalus mongholicus have antioxidative function. Therefore, we studied effects of Astragalus mongholicus and its fermentation objects on anti-oxidation capability of hypothyroidism rats, and then discussed its mechanism of action. Methods: Eighty Wistar rats, half of which are female, were randomly divided into eight groups. They were named normal control group, hypothyroidism model group, high-dose Astragalus mongholicus group, medium-dose Astragalus mongholicus group, low-dose Astragalus mongholicus group, high-dose Astragalus mongholicus fermentation objects group, medium-dose Astragalus mongholicus fermentation objects group, low-dose Astragalus mongholicus fermentation objects group. There were ten rats in each group. We copied hypothyroidism rats samples by chemical induction------0.05% PTU freely drinking water. The rats were treated by different doses of Astragalus mongholicus as well as its, fermentation objects and killed after four weeks. We tested activity of serum superoxide dismutases (SOD), glutathion peroxidase (GSH-Px) nitricoxide synthase (NOS); contents of malondialdehyde (MDA), nitrogen monoxidum (NO) and the function of glandula thyreoidea. Results: After being treated by Astragalus mongholicus as well as its fermentation objects, the hypothyroidism rats’ function of glandula thyreoidea has improved evidently (P<0.05). Secondly, contents of malondialdehyde (MDA) in blood serum degraded remarkably (P<0.05). Thirdly, activity of superoxide dismutases (SOD) and glutathione. Peroxidase (GSH-Px) in blood serum stepped up strikingly (P<0.05). Fourthly, vis vitalis of nitric oxide synthase (NOS) and contents of nitrogen monoxidum (NO) in blood serum stepped down surprisingly (P<0.05). Conclusion: Astragalus mongholicus and its fermentation objects have certain therapeutical effects on thyroid hypofunction, whose mechanism has something to do with increasing anti-oxidation capability of hypothyroidism rats.

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6)
DOI 10.11648/j.ajcem.20210906.14
Page(s) 209-214
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Astragalus Mongholicus and Its Fermentation Objects, Hypothyroidism Rats, Anti-oxidation Capability

References
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Cite This Article
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    Yang Xiaohui, Li Chao, Zhang Jingjing, Yu Yongjun, Li Rongyao, et al. (2021). Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats. American Journal of Clinical and Experimental Medicine, 9(6), 209-214. https://doi.org/10.11648/j.ajcem.20210906.14

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    ACS Style

    Yang Xiaohui; Li Chao; Zhang Jingjing; Yu Yongjun; Li Rongyao, et al. Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats. Am. J. Clin. Exp. Med. 2021, 9(6), 209-214. doi: 10.11648/j.ajcem.20210906.14

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    AMA Style

    Yang Xiaohui, Li Chao, Zhang Jingjing, Yu Yongjun, Li Rongyao, et al. Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats. Am J Clin Exp Med. 2021;9(6):209-214. doi: 10.11648/j.ajcem.20210906.14

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  • @article{10.11648/j.ajcem.20210906.14,
      author = {Yang Xiaohui and Li Chao and Zhang Jingjing and Yu Yongjun and Li Rongyao and Liu Chao and Hou Zhenjiang},
      title = {Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {9},
      number = {6},
      pages = {209-214},
      doi = {10.11648/j.ajcem.20210906.14},
      url = {https://doi.org/10.11648/j.ajcem.20210906.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.14},
      abstract = {Objectives: The morbidity rate of hypothyroidism is relatively high, the features of which are delitescent invasion, long course, untypical symptoms, great harm, etc. To intervene and cure hypothyroidism by traditional Chinese medicine could palliate untoward reaction of Western medicine, relieve symptoms of patients and enhance immunity. Astragalus mongholicus is frequently used as clinical traditional Chinese medicine. Reported by some literatures, compositions of Astragalus mongholicus have antioxidative function. Therefore, we studied effects of Astragalus mongholicus and its fermentation objects on anti-oxidation capability of hypothyroidism rats, and then discussed its mechanism of action. Methods: Eighty Wistar rats, half of which are female, were randomly divided into eight groups. They were named normal control group, hypothyroidism model group, high-dose Astragalus mongholicus group, medium-dose Astragalus mongholicus group, low-dose Astragalus mongholicus group, high-dose Astragalus mongholicus fermentation objects group, medium-dose Astragalus mongholicus fermentation objects group, low-dose Astragalus mongholicus fermentation objects group. There were ten rats in each group. We copied hypothyroidism rats samples by chemical induction------0.05% PTU freely drinking water. The rats were treated by different doses of Astragalus mongholicus as well as its, fermentation objects and killed after four weeks. We tested activity of serum superoxide dismutases (SOD), glutathion peroxidase (GSH-Px) nitricoxide synthase (NOS); contents of malondialdehyde (MDA), nitrogen monoxidum (NO) and the function of glandula thyreoidea. Results: After being treated by Astragalus mongholicus as well as its fermentation objects, the hypothyroidism rats’ function of glandula thyreoidea has improved evidently (PConclusion: Astragalus mongholicus and its fermentation objects have certain therapeutical effects on thyroid hypofunction, whose mechanism has something to do with increasing anti-oxidation capability of hypothyroidism rats.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Effects of Astragalus Mongholicus and Its Fermentation Objects on Anti-oxidation Capability of Hypothyroidism Rats
    AU  - Yang Xiaohui
    AU  - Li Chao
    AU  - Zhang Jingjing
    AU  - Yu Yongjun
    AU  - Li Rongyao
    AU  - Liu Chao
    AU  - Hou Zhenjiang
    Y1  - 2021/12/07
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajcem.20210906.14
    DO  - 10.11648/j.ajcem.20210906.14
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 209
    EP  - 214
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20210906.14
    AB  - Objectives: The morbidity rate of hypothyroidism is relatively high, the features of which are delitescent invasion, long course, untypical symptoms, great harm, etc. To intervene and cure hypothyroidism by traditional Chinese medicine could palliate untoward reaction of Western medicine, relieve symptoms of patients and enhance immunity. Astragalus mongholicus is frequently used as clinical traditional Chinese medicine. Reported by some literatures, compositions of Astragalus mongholicus have antioxidative function. Therefore, we studied effects of Astragalus mongholicus and its fermentation objects on anti-oxidation capability of hypothyroidism rats, and then discussed its mechanism of action. Methods: Eighty Wistar rats, half of which are female, were randomly divided into eight groups. They were named normal control group, hypothyroidism model group, high-dose Astragalus mongholicus group, medium-dose Astragalus mongholicus group, low-dose Astragalus mongholicus group, high-dose Astragalus mongholicus fermentation objects group, medium-dose Astragalus mongholicus fermentation objects group, low-dose Astragalus mongholicus fermentation objects group. There were ten rats in each group. We copied hypothyroidism rats samples by chemical induction------0.05% PTU freely drinking water. The rats were treated by different doses of Astragalus mongholicus as well as its, fermentation objects and killed after four weeks. We tested activity of serum superoxide dismutases (SOD), glutathion peroxidase (GSH-Px) nitricoxide synthase (NOS); contents of malondialdehyde (MDA), nitrogen monoxidum (NO) and the function of glandula thyreoidea. Results: After being treated by Astragalus mongholicus as well as its fermentation objects, the hypothyroidism rats’ function of glandula thyreoidea has improved evidently (PConclusion: Astragalus mongholicus and its fermentation objects have certain therapeutical effects on thyroid hypofunction, whose mechanism has something to do with increasing anti-oxidation capability of hypothyroidism rats.
    VL  - 9
    IS  - 6
    ER  - 

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Author Information
  • Science and Technology Experiment Center, Cangzhou Medical College, Cangzhou, China

  • Department of Preclinical Medicine, Cangzhou Medical College, Cangzhou, China

  • Department of Scientific Research, Cangzhou Medical College, Cangzhou, China

  • Department of Traditional Chinese Medicine, Cangzhou Medical College, Cangzhou, China

  • Department of Preclinical Medicine, Cangzhou Medical College, Cangzhou, China

  • Pharmacy Department, Cangzhou Medical College, Cangzhou, China

  • Institute of Thyroid Disease Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

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