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Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO

Received: 18 October 2021     Accepted: 9 November 2021     Published: 12 November 2021
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Abstract

We studied the expression features of Hepcidin (HEP), Erythropoietin (EPO), Albumin (ALB) and Prealbumin (PA), and the pathogenesis of anemia in tumor patients caused by radiotherapy. We tested the hemoglobin (HB) concentration in 446 cancer patients who received radiotherapy, and measured the serum HEP, EPO, ALB and PA n 92 cases to explore the pathogenesis of anemia caused by radiotherapy. The results were: (1) The HB level before and after radiotherapy in 446 patients were 119.85±19.87g/L and 116.32±24.25g/L (t=2.5211, P<0.05). The cases of anemia before and after radiotherapy were 146 cases and 175 cases (χ2=4.09, P<0.05). (2) The HB level before and after radiotherapy in 92 patients and in 20 cases of control group were respectively 127.33±17.12, 119.41±17.05 and 132.80±11.80g/L, the difference was statistically significant (F=11.70, P<0.01). The anemia cases were 14 and 27, respectively, which were also statistically significant (χ2=8.68, P<0.01). (3) The HEP level before and after radiotherapy in 92 patients and in 20 cases of control group were 3.38±2.48, 2.37±1.37 and 3.22±1.10mg/mL respectively, the difference was statistically significant (F=3.88, P<0.05). (4) EPO level before and after radiotherapy in 92 patients and in 20 controls were 5.05±3.50, 5.75±1.99 and 3.81±1.15mg/mL respectively, the difference was statistically significant (F=9.18, P<0.01). (5) The levels of ALB and PA before radiotherapy in 92 patients were higher than those after radiotherapy. (6) HEP was negatively correlated with HB before radiotherapy (r=-0.2938, t=2.9089, P<0.01), but HEP was not correlated with HB after radiotherapy (r=- 0.0111, P>0.05). (7) There were positive correlation between ALB and HB before and after radiotherapy (all P<0.01). (8) There were positive correlation between PA and HB before and after radiotherapy (all P<0.01). Therefore, Radiotherapy could cause anemia and deteriorate nutritional status in cancer patients. Anemia negatively feedback inhibited the expression of HEP, while EPO was highly compensatory.

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6)
DOI 10.11648/j.ajcem.20210906.11
Page(s) 183-186
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Radiotherapy, Anemia, Hepcidin, Erythropoietin (EPO), Tumor, Albumin, Prealbumin

References
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  • APA Style

    Shan Tiantian, Cheng Zhen, Zuo Erdong, Yan Min, Pan Xiangtao. (2021). Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO. American Journal of Clinical and Experimental Medicine, 9(6), 183-186. https://doi.org/10.11648/j.ajcem.20210906.11

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    ACS Style

    Shan Tiantian; Cheng Zhen; Zuo Erdong; Yan Min; Pan Xiangtao. Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO. Am. J. Clin. Exp. Med. 2021, 9(6), 183-186. doi: 10.11648/j.ajcem.20210906.11

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    AMA Style

    Shan Tiantian, Cheng Zhen, Zuo Erdong, Yan Min, Pan Xiangtao. Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO. Am J Clin Exp Med. 2021;9(6):183-186. doi: 10.11648/j.ajcem.20210906.11

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  • @article{10.11648/j.ajcem.20210906.11,
      author = {Shan Tiantian and Cheng Zhen and Zuo Erdong and Yan Min and Pan Xiangtao},
      title = {Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {9},
      number = {6},
      pages = {183-186},
      doi = {10.11648/j.ajcem.20210906.11},
      url = {https://doi.org/10.11648/j.ajcem.20210906.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.11},
      abstract = {We studied the expression features of Hepcidin (HEP), Erythropoietin (EPO), Albumin (ALB) and Prealbumin (PA), and the pathogenesis of anemia in tumor patients caused by radiotherapy. We tested the hemoglobin (HB) concentration in 446 cancer patients who received radiotherapy, and measured the serum HEP, EPO, ALB and PA n 92 cases to explore the pathogenesis of anemia caused by radiotherapy. The results were: (1) The HB level before and after radiotherapy in 446 patients were 119.85±19.87g/L and 116.32±24.25g/L (t=2.5211, Pχ2=4.09, PF=11.70, Pχ2=8.68, PF=3.88, PF=9.18, Pr=-0.2938, t=2.9089, Pr=- 0.0111, P>0.05). (7) There were positive correlation between ALB and HB before and after radiotherapy (all PP<0.01). Therefore, Radiotherapy could cause anemia and deteriorate nutritional status in cancer patients. Anemia negatively feedback inhibited the expression of HEP, while EPO was highly compensatory.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO
    AU  - Shan Tiantian
    AU  - Cheng Zhen
    AU  - Zuo Erdong
    AU  - Yan Min
    AU  - Pan Xiangtao
    Y1  - 2021/11/12
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajcem.20210906.11
    DO  - 10.11648/j.ajcem.20210906.11
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 183
    EP  - 186
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20210906.11
    AB  - We studied the expression features of Hepcidin (HEP), Erythropoietin (EPO), Albumin (ALB) and Prealbumin (PA), and the pathogenesis of anemia in tumor patients caused by radiotherapy. We tested the hemoglobin (HB) concentration in 446 cancer patients who received radiotherapy, and measured the serum HEP, EPO, ALB and PA n 92 cases to explore the pathogenesis of anemia caused by radiotherapy. The results were: (1) The HB level before and after radiotherapy in 446 patients were 119.85±19.87g/L and 116.32±24.25g/L (t=2.5211, Pχ2=4.09, PF=11.70, Pχ2=8.68, PF=3.88, PF=9.18, Pr=-0.2938, t=2.9089, Pr=- 0.0111, P>0.05). (7) There were positive correlation between ALB and HB before and after radiotherapy (all PP<0.01). Therefore, Radiotherapy could cause anemia and deteriorate nutritional status in cancer patients. Anemia negatively feedback inhibited the expression of HEP, while EPO was highly compensatory.
    VL  - 9
    IS  - 6
    ER  - 

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Author Information
  • Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China

  • Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China

  • Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China

  • Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China

  • Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China

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