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Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats

Received: 26 March 2018     Accepted: 12 April 2018     Published: 24 May 2018
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Abstract

objective: The present study aimed to evaluate the therapeutic effects of ketangmin (KTM) on streptozotocin-(STZ) induced diabetic symptoms and their potential mechanisms. Methods: The effect of KTM on body weight, blood glucose, damaged pancreafic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. Results: The results show that administration of KTM can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with KTM 6 weeks later. Therefore, we may assume that KTM is effective in the protection of STZ-induced diabetic rats and KTM may be of use as antihyperglycemic agent.

Published in American Journal of Clinical and Experimental Medicine (Volume 6, Issue 3)
DOI 10.11648/j.ajcem.20180603.11
Page(s) 64-68
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Ketangmin (KTM), Streptozotocin-Induced Diabetic Symptoms, Potential Mechanisms

References
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[3] Naoto Egawa, Yingsong Lin, Taku Tabata et al., ABO blood type, long-standing diabetes, and the risk of pancreatic cancer. World J Gastroenterol. 2013 Apr 28; 19(16): 2537–2542.
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[6] M. W Massing, C. A. Sueta, M. Chowdhury, D. P. Biggs, and R. J. Simpson Jr., "Lipid manage-ment among coronary artery disease patients with diabetes mellitus or advanced age," The American Journal of Cardiology, vol. 87, no. 5, pp. 646-649, 2001.
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  • APA Style

    Baozhong Diao, Weirong Jin, Feng E. Zhang, Wenzhou Zhang. (2018). Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats. American Journal of Clinical and Experimental Medicine, 6(3), 64-68. https://doi.org/10.11648/j.ajcem.20180603.11

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    ACS Style

    Baozhong Diao; Weirong Jin; Feng E. Zhang; Wenzhou Zhang. Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats. Am. J. Clin. Exp. Med. 2018, 6(3), 64-68. doi: 10.11648/j.ajcem.20180603.11

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    AMA Style

    Baozhong Diao, Weirong Jin, Feng E. Zhang, Wenzhou Zhang. Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats. Am J Clin Exp Med. 2018;6(3):64-68. doi: 10.11648/j.ajcem.20180603.11

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  • @article{10.11648/j.ajcem.20180603.11,
      author = {Baozhong Diao and Weirong Jin and Feng E. Zhang and Wenzhou Zhang},
      title = {Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {6},
      number = {3},
      pages = {64-68},
      doi = {10.11648/j.ajcem.20180603.11},
      url = {https://doi.org/10.11648/j.ajcem.20180603.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20180603.11},
      abstract = {objective: The present study aimed to evaluate the therapeutic effects of ketangmin (KTM) on streptozotocin-(STZ) induced diabetic symptoms and their potential mechanisms. Methods: The effect of KTM on body weight, blood glucose, damaged pancreafic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. Results: The results show that administration of KTM can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with KTM 6 weeks later. Therefore, we may assume that KTM is effective in the protection of STZ-induced diabetic rats and KTM may be of use as antihyperglycemic agent.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats
    AU  - Baozhong Diao
    AU  - Weirong Jin
    AU  - Feng E. Zhang
    AU  - Wenzhou Zhang
    Y1  - 2018/05/24
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ajcem.20180603.11
    DO  - 10.11648/j.ajcem.20180603.11
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 64
    EP  - 68
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20180603.11
    AB  - objective: The present study aimed to evaluate the therapeutic effects of ketangmin (KTM) on streptozotocin-(STZ) induced diabetic symptoms and their potential mechanisms. Methods: The effect of KTM on body weight, blood glucose, damaged pancreafic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. Results: The results show that administration of KTM can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with KTM 6 weeks later. Therefore, we may assume that KTM is effective in the protection of STZ-induced diabetic rats and KTM may be of use as antihyperglycemic agent.
    VL  - 6
    IS  - 3
    ER  - 

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Author Information
  • Department of Formulation Branch, Liaocheng People's Hospital, Liaocheng, China

  • Department of Formulation Branch, Liaocheng People's Hospital, Liaocheng, China

  • Department of Emergency, Liaocheng People's Hospital, Liaocheng, China

  • Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, China

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