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Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris

Received: 25 January 2017     Accepted: 10 February 2017     Published: 1 March 2017
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Abstract

Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.

Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 2)
DOI 10.11648/j.ajcem.20170502.11
Page(s) 30-35
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Acne Vulgaris, Autologous Serum, Doxycycline, Estradiol

References
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[18] Kogawa A C & Salgado H R N. Doxycycline Hyclate: A Review Of Properties, Applications And Analytical Methods. Pharmaceutical analysis. 2012. 2 (4): 11-25.
[19] Simonart T. Newer Approaches to the Treatment of Acne Vulgaris. Clin Am. J Dermatol. 2012. 13 (6): 357-64.
[20] Werner M. A Systematic Review of the Effects and Side Effects of Treatment with Oral Tetracycline in Acne Vulgaris. Master Thesis in Medicine. 2013.
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[22] Elahmed H H. Management of Acne Vulgaris with Hormonal Therapies in Adult Female Patients. Dermatology Therapy. 2015. 4: 166-72.
[23] Shu Y Y & Maibach H I. Estrogen and Skin. Am. J Clin Dermatol. 2011. 12 (5): 297 -311.
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Cite This Article
  • APA Style

    Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. (2017). Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. American Journal of Clinical and Experimental Medicine, 5(2), 30-35. https://doi.org/10.11648/j.ajcem.20170502.11

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    ACS Style

    Muhlis Yunus; Anis Irawan Anwar; Siswanto Wahab; Farida Tabri; Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am. J. Clin. Exp. Med. 2017, 5(2), 30-35. doi: 10.11648/j.ajcem.20170502.11

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    AMA Style

    Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am J Clin Exp Med. 2017;5(2):30-35. doi: 10.11648/j.ajcem.20170502.11

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  • @article{10.11648/j.ajcem.20170502.11,
      author = {Muhlis Yunus and Anis Irawan Anwar and Siswanto Wahab and Farida Tabri and Ilhamjaya Patellongi and Johanes Widodo},
      title = {Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {5},
      number = {2},
      pages = {30-35},
      doi = {10.11648/j.ajcem.20170502.11},
      url = {https://doi.org/10.11648/j.ajcem.20170502.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170502.11},
      abstract = {Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris
    AU  - Muhlis Yunus
    AU  - Anis Irawan Anwar
    AU  - Siswanto Wahab
    AU  - Farida Tabri
    AU  - Ilhamjaya Patellongi
    AU  - Johanes Widodo
    Y1  - 2017/03/01
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ajcem.20170502.11
    DO  - 10.11648/j.ajcem.20170502.11
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 30
    EP  - 35
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20170502.11
    AB  - Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.
    VL  - 5
    IS  - 2
    ER  - 

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Author Information
  • Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia

  • Department of Dermatology and Venereology, Medical Faculty, Gadjah Mada University, Jogjakarta, Indonesia

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