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Age as a Risk Factor of Relapse Occurrence in Acute Lymphoblastic Leukemia-L1 (All-L1) in Children

Received: 23 April 2015     Accepted: 6 May 2015     Published: 21 May 2015
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Abstract

Introduction: Relapse in children with leukemia is a phase appearing the leukemia cells after complete remission; this situation can impact the children itself, parents and also the support system. Objective: To identify the factors related of relapse incidence in children with leukemia. Methods: This study was conducted by using a retrospective cohort study design based on medical record data from Dr. Wahidin Sudirohusodo Hospital, Makassar from December 2013 until August 2014. Study samples were children of 0 month – 18 years old diagnosed of having Acute Lymphoblastic Leukemia-L1. They are treated with chemotherapy and divided into relapse and non-relapse samples. Results: From 42 relapse and non-relapse samples, there were 35.7% (15) relapse samples and 64.3% (27) non relapse samples. Bivariate analyses revealed that among 1-10 year, there were 31.4% (11) with relapse and 68.6% (24) without relapse. Among the samples aged more than 10 years old, there were 57.1% (4) samples with relapse and 42.9% (3) samples without relapse, with p=0.225 (p>0.05). In terms of interval time from first diagnosis until the occurrence of relapse, the median value was 1.80 in 1-10 year-old group. In the group of >10 years old, the median value was 0.84 and p=0.207 (p>0.05). Conclusion: Age did not give any influence in the incidence of relapse in children with ALL-L1 and the interval time when the first diagnosed until relapse.

Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 3)
DOI 10.11648/j.ajcem.20150303.19
Page(s) 124-127
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Acute Lymphoblastic Leukemia-L1, Relapse, Age, Children

References
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  • APA Style

    Yulianty Mochtar, Nadirah Rasyid Ridha, Dasril Daud. (2015). Age as a Risk Factor of Relapse Occurrence in Acute Lymphoblastic Leukemia-L1 (All-L1) in Children. American Journal of Clinical and Experimental Medicine, 3(3), 124-127. https://doi.org/10.11648/j.ajcem.20150303.19

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    ACS Style

    Yulianty Mochtar; Nadirah Rasyid Ridha; Dasril Daud. Age as a Risk Factor of Relapse Occurrence in Acute Lymphoblastic Leukemia-L1 (All-L1) in Children. Am. J. Clin. Exp. Med. 2015, 3(3), 124-127. doi: 10.11648/j.ajcem.20150303.19

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    AMA Style

    Yulianty Mochtar, Nadirah Rasyid Ridha, Dasril Daud. Age as a Risk Factor of Relapse Occurrence in Acute Lymphoblastic Leukemia-L1 (All-L1) in Children. Am J Clin Exp Med. 2015;3(3):124-127. doi: 10.11648/j.ajcem.20150303.19

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  • @article{10.11648/j.ajcem.20150303.19,
      author = {Yulianty Mochtar and Nadirah Rasyid Ridha and Dasril Daud},
      title = {Age as a Risk Factor of Relapse Occurrence in Acute Lymphoblastic Leukemia-L1 (All-L1) in Children},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {3},
      number = {3},
      pages = {124-127},
      doi = {10.11648/j.ajcem.20150303.19},
      url = {https://doi.org/10.11648/j.ajcem.20150303.19},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150303.19},
      abstract = {Introduction: Relapse in children with leukemia is a phase appearing the leukemia cells after complete remission; this situation can impact the children itself, parents and also the support system. Objective: To identify the factors related of relapse incidence in children with leukemia. Methods: This study was conducted by using a retrospective cohort study design based on medical record data from Dr. Wahidin Sudirohusodo Hospital, Makassar from December 2013 until August 2014. Study samples were children of 0 month – 18 years old diagnosed of having Acute Lymphoblastic Leukemia-L1. They are treated with chemotherapy and divided into relapse and non-relapse samples. Results: From 42 relapse and non-relapse samples, there were 35.7% (15) relapse samples and 64.3% (27) non relapse samples. Bivariate analyses revealed that among 1-10 year, there were 31.4% (11) with relapse and 68.6% (24) without relapse. Among the samples aged more than 10 years old, there were 57.1% (4) samples with relapse and 42.9% (3) samples without relapse, with p=0.225 (p>0.05). In terms of interval time from first diagnosis until the occurrence of relapse, the median value was 1.80 in 1-10 year-old group. In the group of >10 years old, the median value was 0.84 and p=0.207 (p>0.05). Conclusion: Age did not give any influence in the incidence of relapse in children with ALL-L1 and the interval time when the first diagnosed until relapse.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Age as a Risk Factor of Relapse Occurrence in Acute Lymphoblastic Leukemia-L1 (All-L1) in Children
    AU  - Yulianty Mochtar
    AU  - Nadirah Rasyid Ridha
    AU  - Dasril Daud
    Y1  - 2015/05/21
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajcem.20150303.19
    DO  - 10.11648/j.ajcem.20150303.19
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 124
    EP  - 127
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20150303.19
    AB  - Introduction: Relapse in children with leukemia is a phase appearing the leukemia cells after complete remission; this situation can impact the children itself, parents and also the support system. Objective: To identify the factors related of relapse incidence in children with leukemia. Methods: This study was conducted by using a retrospective cohort study design based on medical record data from Dr. Wahidin Sudirohusodo Hospital, Makassar from December 2013 until August 2014. Study samples were children of 0 month – 18 years old diagnosed of having Acute Lymphoblastic Leukemia-L1. They are treated with chemotherapy and divided into relapse and non-relapse samples. Results: From 42 relapse and non-relapse samples, there were 35.7% (15) relapse samples and 64.3% (27) non relapse samples. Bivariate analyses revealed that among 1-10 year, there were 31.4% (11) with relapse and 68.6% (24) without relapse. Among the samples aged more than 10 years old, there were 57.1% (4) samples with relapse and 42.9% (3) samples without relapse, with p=0.225 (p>0.05). In terms of interval time from first diagnosis until the occurrence of relapse, the median value was 1.80 in 1-10 year-old group. In the group of >10 years old, the median value was 0.84 and p=0.207 (p>0.05). Conclusion: Age did not give any influence in the incidence of relapse in children with ALL-L1 and the interval time when the first diagnosed until relapse.
    VL  - 3
    IS  - 3
    ER  - 

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Author Information
  • Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, Indonesia

  • Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, Indonesia

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