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Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats

Received: 23 March 2022     Accepted: 7 April 2022     Published: 26 April 2022
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Abstract

Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats were grouped into 3 (n=15/group): Group 1- Control, Group 2- Diabetes, Group 3- Postprandial hyperglycemia. The 15 rats per group were sub-grouped into 3 of 5 rats each. Each sub-group determined gastric emptying, intestinal propulsion, and colonic motility. Diabetes was induced with a single intraperitoneal 150 mg/kg alloxan and the postprandial received an oral D - glucose load of 2 g/kg. Before the commencement of each experimental procedure, rats in all groups fasted for 18 hours and blood glucose concentration was assessed by the glucose oxidase method after 45 min of onset of the experiment. The mean ± SEM of data were subjected to one-way ANOVA analysis and values of p<0.05 were considered significant. There was a significant decrease in the fasting blood glucose level (mmol/L) in rats of control (3.64 ± 0.10) compared with the diabetic (31.94 ± 2.38). The percentage of gastric emptying in the control decreased significantly compared with the diabetics. The percentage of intestinal propulsion in the control (42.14 ± 3.14) increased significantly compared with the diabetic (7.43 ± 1.05) and significantly decrease when compared with the postprandial (72.91 ± 5.47). There colonic motility time in the control decreased significantly compared with the diabetic. Diabetes promotes delay in the different motility examined while the postprandial group supported intestinal propulsion. Further work should focus on identifying the mechanism involved.

Published in American Journal of Biomedical and Life Sciences (Volume 10, Issue 2)
DOI 10.11648/j.ajbls.20221002.18
Page(s) 49-54
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Diabetes, Gastrointestinal Motility, Gastric Emptying, Intestinal Propulsion, Colonic Motility, Postprandial Hyperglycemia

References
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[3] Rayner CK, Schwartz MP, van Dam PS, et al. Small intestinal glucose absorption and duodenal motility in type 1 diabetes mellitus. Am J Gastroenterol 2002; 97: 3123–3130.
[4] Chaikomin R, Keng LW, Doran S, et al. Concurrent duodenal manometric and impedance recording to evaluate the effects of hyoscine on motility and flow events, glucose absorption, and incretin release. Am J Physiol Gastrointest Liver Physiol; 292. Epub ahead of print April 2007. DOI: 10.1152/AJPGI.00519.2006.
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    Odukanmi Olugbenga Adeola. (2022). Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats. American Journal of Biomedical and Life Sciences, 10(2), 49-54. https://doi.org/10.11648/j.ajbls.20221002.18

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    Odukanmi Olugbenga Adeola. Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats. Am. J. Biomed. Life Sci. 2022, 10(2), 49-54. doi: 10.11648/j.ajbls.20221002.18

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    AMA Style

    Odukanmi Olugbenga Adeola. Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats. Am J Biomed Life Sci. 2022;10(2):49-54. doi: 10.11648/j.ajbls.20221002.18

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  • @article{10.11648/j.ajbls.20221002.18,
      author = {Odukanmi Olugbenga Adeola},
      title = {Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {10},
      number = {2},
      pages = {49-54},
      doi = {10.11648/j.ajbls.20221002.18},
      url = {https://doi.org/10.11648/j.ajbls.20221002.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221002.18},
      abstract = {Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats were grouped into 3 (n=15/group): Group 1- Control, Group 2- Diabetes, Group 3- Postprandial hyperglycemia. The 15 rats per group were sub-grouped into 3 of 5 rats each. Each sub-group determined gastric emptying, intestinal propulsion, and colonic motility. Diabetes was induced with a single intraperitoneal 150 mg/kg alloxan and the postprandial received an oral D - glucose load of 2 g/kg. Before the commencement of each experimental procedure, rats in all groups fasted for 18 hours and blood glucose concentration was assessed by the glucose oxidase method after 45 min of onset of the experiment. The mean ± SEM of data were subjected to one-way ANOVA analysis and values of p<0.05 were considered significant. There was a significant decrease in the fasting blood glucose level (mmol/L) in rats of control (3.64 ± 0.10) compared with the diabetic (31.94 ± 2.38). The percentage of gastric emptying in the control decreased significantly compared with the diabetics. The percentage of intestinal propulsion in the control (42.14 ± 3.14) increased significantly compared with the diabetic (7.43 ± 1.05) and significantly decrease when compared with the postprandial (72.91 ± 5.47). There colonic motility time in the control decreased significantly compared with the diabetic. Diabetes promotes delay in the different motility examined while the postprandial group supported intestinal propulsion. Further work should focus on identifying the mechanism involved.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats
    AU  - Odukanmi Olugbenga Adeola
    Y1  - 2022/04/26
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ajbls.20221002.18
    DO  - 10.11648/j.ajbls.20221002.18
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
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    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20221002.18
    AB  - Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats were grouped into 3 (n=15/group): Group 1- Control, Group 2- Diabetes, Group 3- Postprandial hyperglycemia. The 15 rats per group were sub-grouped into 3 of 5 rats each. Each sub-group determined gastric emptying, intestinal propulsion, and colonic motility. Diabetes was induced with a single intraperitoneal 150 mg/kg alloxan and the postprandial received an oral D - glucose load of 2 g/kg. Before the commencement of each experimental procedure, rats in all groups fasted for 18 hours and blood glucose concentration was assessed by the glucose oxidase method after 45 min of onset of the experiment. The mean ± SEM of data were subjected to one-way ANOVA analysis and values of p<0.05 were considered significant. There was a significant decrease in the fasting blood glucose level (mmol/L) in rats of control (3.64 ± 0.10) compared with the diabetic (31.94 ± 2.38). The percentage of gastric emptying in the control decreased significantly compared with the diabetics. The percentage of intestinal propulsion in the control (42.14 ± 3.14) increased significantly compared with the diabetic (7.43 ± 1.05) and significantly decrease when compared with the postprandial (72.91 ± 5.47). There colonic motility time in the control decreased significantly compared with the diabetic. Diabetes promotes delay in the different motility examined while the postprandial group supported intestinal propulsion. Further work should focus on identifying the mechanism involved.
    VL  - 10
    IS  - 2
    ER  - 

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Author Information
  • Laboratory for Gastrointestinal Secretions and Inflammation, Department of Physiology, University of Ibadan, Ibadan, Nigeria

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