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A Cross Sectional Study to Assess the Association of Thyroid Autoantibodies with Thyroid Malignancies in a Tertiary Care Hospital in Bangladesh

Received: 13 April 2021     Accepted: 15 June 2021     Published: 30 June 2021
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Abstract

Thyroid cancer is the most common endocrine malignant lesion and its incidence continues to rise. The aim of this study was to assess association between thyroid antibodies and thyroid malignancies. This was a cross sectional study of 120 patients with thyroid nodules undergoing thyroidectomy with recorded preoperative thyroid antibodies [autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb)] levels from 2017 to 2018 admitted at the ENT Department of Chittagong Medical College Hospital, Chittagong. Analysis was done to assess the association between preoperative thyroid antibody levels, fine needle aspiration cytology (FNAC) results, type of thyroid surgery and final histopathology. Mean age of the study population was 35.58 years (SD:±11.36). According to the final histopathological diagnosis of the 120 patients 80% were benign and other 20% were malignant. Men are more likely to suffer from thyroid malignancy than women (33.3% versus 18.9%). Multinodules are predominant group than solitary nodule (55% versus 45%). Though the prevalence of thyroid malignancies is more in solitary group than multinodules group (22.2% versus 18.2%) the difference is not statistically significant. Among the benign nodules most of them (88.5%) were nodular goiter and among the malignancies most of them were (80.3%) were papillary thyroid carcinoma. There is moderate agreement between FNA and histopathological diagnosis (kappa is .405). The patients with high TSH level in comparison to low TSH level were significantly associated with thyroid malignancy. The patients with preoperative elevated TgAb (≥ 40IU/mL) has 2.55 times of more chance to have malignant lesion than the patients who has normal TgAb level. The study revealed that elevated level of TgAb may act as an independent prediction factor for thyroid malignancy.

Published in American Journal of Biomedical and Life Sciences (Volume 9, Issue 3)
DOI 10.11648/j.ajbls.20210903.14
Page(s) 166-175
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Thyroid Nodule, Autoantibody, Malignancy

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    Mitan Chakma, Milton Barua, Kyaw Khin U, Mahmud Ullah Faruquee, Sayed Muhammad Alauddin Sharif, et al. (2021). A Cross Sectional Study to Assess the Association of Thyroid Autoantibodies with Thyroid Malignancies in a Tertiary Care Hospital in Bangladesh. American Journal of Biomedical and Life Sciences, 9(3), 166-175. https://doi.org/10.11648/j.ajbls.20210903.14

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    ACS Style

    Mitan Chakma; Milton Barua; Kyaw Khin U; Mahmud Ullah Faruquee; Sayed Muhammad Alauddin Sharif, et al. A Cross Sectional Study to Assess the Association of Thyroid Autoantibodies with Thyroid Malignancies in a Tertiary Care Hospital in Bangladesh. Am. J. Biomed. Life Sci. 2021, 9(3), 166-175. doi: 10.11648/j.ajbls.20210903.14

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    AMA Style

    Mitan Chakma, Milton Barua, Kyaw Khin U, Mahmud Ullah Faruquee, Sayed Muhammad Alauddin Sharif, et al. A Cross Sectional Study to Assess the Association of Thyroid Autoantibodies with Thyroid Malignancies in a Tertiary Care Hospital in Bangladesh. Am J Biomed Life Sci. 2021;9(3):166-175. doi: 10.11648/j.ajbls.20210903.14

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  • @article{10.11648/j.ajbls.20210903.14,
      author = {Mitan Chakma and Milton Barua and Kyaw Khin U and Mahmud Ullah Faruquee and Sayed Muhammad Alauddin Sharif and Shahin Ibn Rahman and Afjal Hossain and Amanat Ullah},
      title = {A Cross Sectional Study to Assess the Association of Thyroid Autoantibodies with Thyroid Malignancies in a Tertiary Care Hospital in Bangladesh},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {9},
      number = {3},
      pages = {166-175},
      doi = {10.11648/j.ajbls.20210903.14},
      url = {https://doi.org/10.11648/j.ajbls.20210903.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210903.14},
      abstract = {Thyroid cancer is the most common endocrine malignant lesion and its incidence continues to rise. The aim of this study was to assess association between thyroid antibodies and thyroid malignancies. This was a cross sectional study of 120 patients with thyroid nodules undergoing thyroidectomy with recorded preoperative thyroid antibodies [autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb)] levels from 2017 to 2018 admitted at the ENT Department of Chittagong Medical College Hospital, Chittagong. Analysis was done to assess the association between preoperative thyroid antibody levels, fine needle aspiration cytology (FNAC) results, type of thyroid surgery and final histopathology. Mean age of the study population was 35.58 years (SD:±11.36). According to the final histopathological diagnosis of the 120 patients 80% were benign and other 20% were malignant. Men are more likely to suffer from thyroid malignancy than women (33.3% versus 18.9%). Multinodules are predominant group than solitary nodule (55% versus 45%). Though the prevalence of thyroid malignancies is more in solitary group than multinodules group (22.2% versus 18.2%) the difference is not statistically significant. Among the benign nodules most of them (88.5%) were nodular goiter and among the malignancies most of them were (80.3%) were papillary thyroid carcinoma. There is moderate agreement between FNA and histopathological diagnosis (kappa is .405). The patients with high TSH level in comparison to low TSH level were significantly associated with thyroid malignancy. The patients with preoperative elevated TgAb (≥ 40IU/mL) has 2.55 times of more chance to have malignant lesion than the patients who has normal TgAb level. The study revealed that elevated level of TgAb may act as an independent prediction factor for thyroid malignancy.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - A Cross Sectional Study to Assess the Association of Thyroid Autoantibodies with Thyroid Malignancies in a Tertiary Care Hospital in Bangladesh
    AU  - Mitan Chakma
    AU  - Milton Barua
    AU  - Kyaw Khin U
    AU  - Mahmud Ullah Faruquee
    AU  - Sayed Muhammad Alauddin Sharif
    AU  - Shahin Ibn Rahman
    AU  - Afjal Hossain
    AU  - Amanat Ullah
    Y1  - 2021/06/30
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajbls.20210903.14
    DO  - 10.11648/j.ajbls.20210903.14
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 166
    EP  - 175
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20210903.14
    AB  - Thyroid cancer is the most common endocrine malignant lesion and its incidence continues to rise. The aim of this study was to assess association between thyroid antibodies and thyroid malignancies. This was a cross sectional study of 120 patients with thyroid nodules undergoing thyroidectomy with recorded preoperative thyroid antibodies [autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb)] levels from 2017 to 2018 admitted at the ENT Department of Chittagong Medical College Hospital, Chittagong. Analysis was done to assess the association between preoperative thyroid antibody levels, fine needle aspiration cytology (FNAC) results, type of thyroid surgery and final histopathology. Mean age of the study population was 35.58 years (SD:±11.36). According to the final histopathological diagnosis of the 120 patients 80% were benign and other 20% were malignant. Men are more likely to suffer from thyroid malignancy than women (33.3% versus 18.9%). Multinodules are predominant group than solitary nodule (55% versus 45%). Though the prevalence of thyroid malignancies is more in solitary group than multinodules group (22.2% versus 18.2%) the difference is not statistically significant. Among the benign nodules most of them (88.5%) were nodular goiter and among the malignancies most of them were (80.3%) were papillary thyroid carcinoma. There is moderate agreement between FNA and histopathological diagnosis (kappa is .405). The patients with high TSH level in comparison to low TSH level were significantly associated with thyroid malignancy. The patients with preoperative elevated TgAb (≥ 40IU/mL) has 2.55 times of more chance to have malignant lesion than the patients who has normal TgAb level. The study revealed that elevated level of TgAb may act as an independent prediction factor for thyroid malignancy.
    VL  - 9
    IS  - 3
    ER  - 

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Author Information
  • Department of Otolaryngology, Chittagong Medical College Hospital, Chittagong, Bangladesh

  • Department of Medicine, Chittagong General Hospital, Chittagong, Bangladesh

  • Department of Otolaryngology, Chittagong Medical College Hospital, Chittagong, Bangladesh

  • Department of Otolaryngology, Chittagong Medical College Hospital, Chittagong, Bangladesh

  • Department of Otolaryngology, Chittagong Medical College Hospital, Chittagong, Bangladesh

  • epartment of Endocrinology, Dhaka National Medical College Hospital, Dhaka, Bangladesh

  • Department of Endocrinology, US Bangla Medical College, Narayanganj, Bangladesh

  • Acute Medicine, Medway Maritime Hospital, Kent, UK

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