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Assessment of the Risk of Hemochromatosis in Polytransfused Sickle Cell Patients at the Abidjan Transfusion Therapy Unit

Received: 15 January 2020     Accepted: 27 January 2020     Published: 7 February 2020
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Abstract

In Côte d'Ivoire, sickle cell disease affects 14% of the population. It is responsible for significant morbidity and mortality. Transfusion is a significant element in the management of major sickle cell anemia, which exposes them to post-transfusion hemochromatosis. The biological diagnosis is based on the determination of serum iron and the transferrin saturation coefficient (CST). As the determination of the CST was not available in our exercise context in Côte d'Ivoire, we determined only the ferritinemia. The interest of this work lies in the therapeutic implication linked to the identification of patients at risk of hemochromatosis because chelators are difficult to access for most patients. This was a prospective, descriptive and analytical study, on polytransfused sickle cell patients, followed at the transfusion therapy unit (UTT) of the CNTS of Abidjan, from 2010 to 2018. We included 78 sickle cell patients, all ages and genders who have received at least ten transfusions. The ferritinemia assay was carried out by ELISA. Transfusion exchange, with 59% of cases, was the most used mode of transfusion. The mean ferritinemia was 1719.19 ng / ml. Hyperferritinemia was found in 63% of patients. Most of the patients were on a long-term transfusion program with an average of 27.5 bags of red blood cell concentrates. Thirty-two patients had received at least 20 bags of red blood cell concentrates. We noted 21 patients treated, including 3 with deferoxamine and 18 treated with oral deferasirox. We have identified 33 sickle cell anemia patients at risk for hemochromatosis. The determinants of the risk of hemochromatosis were the high number of blood bags and the method of transfusion.

Published in American Journal of Biomedical and Life Sciences (Volume 8, Issue 1)
DOI 10.11648/j.ajbls.20200801.15
Page(s) 20-24
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Hemochromatosis, Sickle Cell Disease, Tranfusion

References
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[3] Yawn B. P., Buchanan GR., Afenyi-Annan A. N. et cill. Management of sickle cell disease: summary of the é014 evidence-based report of expert panel members. JAMA, 2014, 312, 1033-1048.
[4] Piel FB, Steinberg MH, Rees DC. Sick Cell Disease. N Engl J Med 2017; 376: 1561-1573.
[5] French Federation of Patients Associations with Hemochromatosis. the diagnosis of Hemochromatosis https://www.hemochromatose.org/hemochromatose/le-diagnostic-de-lhemochromatose/.
[6] Waalen J, Felitti VJ, Gelbart T, Beutler E. Screening for hemochromatosis by measuring ferritin levels: a more effective approach. Blood. 2008 Apr; 111 (7): 3373–6.
[7] A Camacho, S Bouhya, P Latry. Posttransfusion hemosiderosis. Transf. Clin. Biol. 2014, 21 (4-5): 273.
[8] S. Leo-Kodeli, P. Renaudier, B. Lassale. Evaluation of transfusion hemochromatosis prevalence, SFVTT-01 study: Preliminary results of the SFVTT working group. Transf. Clin. Biol. 2014, 21 (4-5): 182–188.
[9] Elira-Dokekias A, Ngoloet O L, Atipo T, Malanda F, Koko I, Montalembert M. Evaluation of blood transfusion in 112 sickle cell patients homozygous at Brazzaville University Hospital. Transf clin biol 2009; 16 (5-6): 464-70.
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[15] M. Touati, D. Berdessoule, C. Rose. Limousin hematology network (Hematolium) Iron overloads in hemopathies. Latest updated version of 11/22/2012 available on: https://hemato.chu-limoges.fr/hematolim/Portals/0/Reseau%20HEMATOLIM/REF%20HEM%20MAL%2010%20Surcharge%20en%20Fer.pdf.
[16] Fung EB, Harmatz P, Milet M. Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload. Am J Hematology 2007; 82: 255-65.
[17] Harmatz P, Butensky E, Quirolo K. Severity of iron overload in patients with sickle cell disease receiving chronic red blood cell transfusion therapy. Blood 2000; 96: 76-79.
[18] Davies S, Henthorn JS, Win A. Effect of blood transfusion on iron status in sickle cell anaemia. Clin Lab Haematol 1984; 6: 17-22.
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    Yassongui Mamadou Sekongo, Kabore Saydou, Kouakou Boidy, Kouamenan Sidonie, Kassogue Kadidja, et al. (2020). Assessment of the Risk of Hemochromatosis in Polytransfused Sickle Cell Patients at the Abidjan Transfusion Therapy Unit. American Journal of Biomedical and Life Sciences, 8(1), 20-24. https://doi.org/10.11648/j.ajbls.20200801.15

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    ACS Style

    Yassongui Mamadou Sekongo; Kabore Saydou; Kouakou Boidy; Kouamenan Sidonie; Kassogue Kadidja, et al. Assessment of the Risk of Hemochromatosis in Polytransfused Sickle Cell Patients at the Abidjan Transfusion Therapy Unit. Am. J. Biomed. Life Sci. 2020, 8(1), 20-24. doi: 10.11648/j.ajbls.20200801.15

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    AMA Style

    Yassongui Mamadou Sekongo, Kabore Saydou, Kouakou Boidy, Kouamenan Sidonie, Kassogue Kadidja, et al. Assessment of the Risk of Hemochromatosis in Polytransfused Sickle Cell Patients at the Abidjan Transfusion Therapy Unit. Am J Biomed Life Sci. 2020;8(1):20-24. doi: 10.11648/j.ajbls.20200801.15

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  • @article{10.11648/j.ajbls.20200801.15,
      author = {Yassongui Mamadou Sekongo and Kabore Saydou and Kouakou Boidy and Kouamenan Sidonie and Kassogue Kadidja and N’Guessan Parfait and Oue Nabo Bertin and Konate Seidou and Sanogo Ibrahima},
      title = {Assessment of the Risk of Hemochromatosis in Polytransfused Sickle Cell Patients at the Abidjan Transfusion Therapy Unit},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {8},
      number = {1},
      pages = {20-24},
      doi = {10.11648/j.ajbls.20200801.15},
      url = {https://doi.org/10.11648/j.ajbls.20200801.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200801.15},
      abstract = {In Côte d'Ivoire, sickle cell disease affects 14% of the population. It is responsible for significant morbidity and mortality. Transfusion is a significant element in the management of major sickle cell anemia, which exposes them to post-transfusion hemochromatosis. The biological diagnosis is based on the determination of serum iron and the transferrin saturation coefficient (CST). As the determination of the CST was not available in our exercise context in Côte d'Ivoire, we determined only the ferritinemia. The interest of this work lies in the therapeutic implication linked to the identification of patients at risk of hemochromatosis because chelators are difficult to access for most patients. This was a prospective, descriptive and analytical study, on polytransfused sickle cell patients, followed at the transfusion therapy unit (UTT) of the CNTS of Abidjan, from 2010 to 2018. We included 78 sickle cell patients, all ages and genders who have received at least ten transfusions. The ferritinemia assay was carried out by ELISA. Transfusion exchange, with 59% of cases, was the most used mode of transfusion. The mean ferritinemia was 1719.19 ng / ml. Hyperferritinemia was found in 63% of patients. Most of the patients were on a long-term transfusion program with an average of 27.5 bags of red blood cell concentrates. Thirty-two patients had received at least 20 bags of red blood cell concentrates. We noted 21 patients treated, including 3 with deferoxamine and 18 treated with oral deferasirox. We have identified 33 sickle cell anemia patients at risk for hemochromatosis. The determinants of the risk of hemochromatosis were the high number of blood bags and the method of transfusion.},
     year = {2020}
    }
    

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    T1  - Assessment of the Risk of Hemochromatosis in Polytransfused Sickle Cell Patients at the Abidjan Transfusion Therapy Unit
    AU  - Yassongui Mamadou Sekongo
    AU  - Kabore Saydou
    AU  - Kouakou Boidy
    AU  - Kouamenan Sidonie
    AU  - Kassogue Kadidja
    AU  - N’Guessan Parfait
    AU  - Oue Nabo Bertin
    AU  - Konate Seidou
    AU  - Sanogo Ibrahima
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    DO  - 10.11648/j.ajbls.20200801.15
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    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
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    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.ajbls.20200801.15
    AB  - In Côte d'Ivoire, sickle cell disease affects 14% of the population. It is responsible for significant morbidity and mortality. Transfusion is a significant element in the management of major sickle cell anemia, which exposes them to post-transfusion hemochromatosis. The biological diagnosis is based on the determination of serum iron and the transferrin saturation coefficient (CST). As the determination of the CST was not available in our exercise context in Côte d'Ivoire, we determined only the ferritinemia. The interest of this work lies in the therapeutic implication linked to the identification of patients at risk of hemochromatosis because chelators are difficult to access for most patients. This was a prospective, descriptive and analytical study, on polytransfused sickle cell patients, followed at the transfusion therapy unit (UTT) of the CNTS of Abidjan, from 2010 to 2018. We included 78 sickle cell patients, all ages and genders who have received at least ten transfusions. The ferritinemia assay was carried out by ELISA. Transfusion exchange, with 59% of cases, was the most used mode of transfusion. The mean ferritinemia was 1719.19 ng / ml. Hyperferritinemia was found in 63% of patients. Most of the patients were on a long-term transfusion program with an average of 27.5 bags of red blood cell concentrates. Thirty-two patients had received at least 20 bags of red blood cell concentrates. We noted 21 patients treated, including 3 with deferoxamine and 18 treated with oral deferasirox. We have identified 33 sickle cell anemia patients at risk for hemochromatosis. The determinants of the risk of hemochromatosis were the high number of blood bags and the method of transfusion.
    VL  - 8
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Author Information
  • Department of Training and Research, National Blood Transfusion Center, Abidjan, C?te D’Ivoire

  • Laboratory of quality control, National Blood Transfusion Center, Abidjan, C?te D’Ivoire

  • Hematology Department, Training and Research Unit of Medical Sciences, Abidjan, C?te D’Ivoire

  • Hemovigilance Service, National Blood Transfusion Center, Abidjan, C?te D’Ivoire

  • Transfusion Therapy Unit, National Blood Transfusion Center, Abidjan, C?te D’Ivoire

  • Transfusion Therapy Unit, National Blood Transfusion Center, Abidjan, C?te D’Ivoire

  • Transfusion Therapy Unit, National Blood Transfusion Center, Abidjan, C?te D’Ivoire

  • General Direction, National Blood Transfusion Center, Abidjan, C?te D’Ivoire

  • Hematology Service, Teaching Hospital Center of Yopogon, Abidjan, C?te D’Ivoire

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