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Mansonella perstans and Plasmodium falciparum Co-infection in the Akonolinga Health District, Centre Region, Cameroon

Received: 25 February 2019     Accepted: 28 March 2019     Published: 13 April 2019
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Abstract

Mansonella perstans and Plasmodium falciparum are among the most common human parasites in Sub-Saharan Africa. They pass through the bloodstream during their life in human host. This study aimed at determining the prevalence, determinants of co-infection with M. perstans and P. falciparum and their possible interaction mechanism. A cross-sectional study was conducted in the Akonolinga Health District among pupils. Each of them was screened for the presence of peripheral blood parasites stages using Giemsa-stained thick and thin blood films. Socio-demographic information was documented using a questionnaire forms. A total of 416 pupils aged 4-15 years (average: 9.17 ± 0.27) were recruited. The overall prevalence was 4.32% and 37.26% for M. perstans and P. falciparum respectively, and prevalence of co-infection was 1.92%. Mean parasite density was 508.7±310.3 (min: 430 - max: 1300) µF/ml for M. perstans and 5240.38±2037.42 (min: 857 – max: 10400) T/μl for P. falciparum. Risks of single infections (aOR = 0.46, P = 0.0264 for M. perstans and aOR = 0.64, P = 0.0432 for P. falciparum) and co-infection (aOR = 0.10, P = 0.0371) were lower for pupils living in urban area than those living in rural area. Parasitemia of both parasite species were similar in single and co-infection situations (P> 0.05). The interaction between these parasites could involve another mechanism than a competition for blood resources. This study outlined that M. perstans and P. falciparum are co-endemic in the Akonolinga health District. In order to guarantee future success in control and eradication of malaria, a bigger attention should be given to M. perstans or other filarial where it is co-endemic with P. falciparum.

Published in American Journal of Biomedical and Life Sciences (Volume 7, Issue 1)
DOI 10.11648/j.ajbls.20190701.14
Page(s) 16-21
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Mansonella perstans, Plasmodium falciparum, Co-infection, Interaction, Akonolinga

References
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    Leopold Gustave Lehman, Martin Gael Oyono, Samuel Fosso, Charles Félix Bilong Bilong. (2019). Mansonella perstans and Plasmodium falciparum Co-infection in the Akonolinga Health District, Centre Region, Cameroon. American Journal of Biomedical and Life Sciences, 7(1), 16-21. https://doi.org/10.11648/j.ajbls.20190701.14

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    ACS Style

    Leopold Gustave Lehman; Martin Gael Oyono; Samuel Fosso; Charles Félix Bilong Bilong. Mansonella perstans and Plasmodium falciparum Co-infection in the Akonolinga Health District, Centre Region, Cameroon. Am. J. Biomed. Life Sci. 2019, 7(1), 16-21. doi: 10.11648/j.ajbls.20190701.14

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    AMA Style

    Leopold Gustave Lehman, Martin Gael Oyono, Samuel Fosso, Charles Félix Bilong Bilong. Mansonella perstans and Plasmodium falciparum Co-infection in the Akonolinga Health District, Centre Region, Cameroon. Am J Biomed Life Sci. 2019;7(1):16-21. doi: 10.11648/j.ajbls.20190701.14

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  • @article{10.11648/j.ajbls.20190701.14,
      author = {Leopold Gustave Lehman and Martin Gael Oyono and Samuel Fosso and Charles Félix Bilong Bilong},
      title = {Mansonella perstans and Plasmodium falciparum Co-infection in the Akonolinga Health District, Centre Region, Cameroon},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {7},
      number = {1},
      pages = {16-21},
      doi = {10.11648/j.ajbls.20190701.14},
      url = {https://doi.org/10.11648/j.ajbls.20190701.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20190701.14},
      abstract = {Mansonella perstans and Plasmodium falciparum are among the most common human parasites in Sub-Saharan Africa. They pass through the bloodstream during their life in human host. This study aimed at determining the prevalence, determinants of co-infection with M. perstans and P. falciparum and their possible interaction mechanism. A cross-sectional study was conducted in the Akonolinga Health District among pupils. Each of them was screened for the presence of peripheral blood parasites stages using Giemsa-stained thick and thin blood films. Socio-demographic information was documented using a questionnaire forms. A total of 416 pupils aged 4-15 years (average: 9.17 ± 0.27) were recruited. The overall prevalence was 4.32% and 37.26% for M. perstans and P. falciparum respectively, and prevalence of co-infection was 1.92%. Mean parasite density was 508.7±310.3 (min: 430 - max: 1300) µF/ml for M. perstans and 5240.38±2037.42 (min: 857 – max: 10400) T/μl for P. falciparum. Risks of single infections (aOR = 0.46, P = 0.0264 for M. perstans and aOR = 0.64, P = 0.0432 for P. falciparum) and co-infection (aOR = 0.10, P = 0.0371) were lower for pupils living in urban area than those living in rural area. Parasitemia of both parasite species were similar in single and co-infection situations (P> 0.05). The interaction between these parasites could involve another mechanism than a competition for blood resources. This study outlined that M. perstans and P. falciparum are co-endemic in the Akonolinga health District. In order to guarantee future success in control and eradication of malaria, a bigger attention should be given to M. perstans or other filarial where it is co-endemic with P. falciparum.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Mansonella perstans and Plasmodium falciparum Co-infection in the Akonolinga Health District, Centre Region, Cameroon
    AU  - Leopold Gustave Lehman
    AU  - Martin Gael Oyono
    AU  - Samuel Fosso
    AU  - Charles Félix Bilong Bilong
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    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajbls.20190701.14
    DO  - 10.11648/j.ajbls.20190701.14
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 16
    EP  - 21
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20190701.14
    AB  - Mansonella perstans and Plasmodium falciparum are among the most common human parasites in Sub-Saharan Africa. They pass through the bloodstream during their life in human host. This study aimed at determining the prevalence, determinants of co-infection with M. perstans and P. falciparum and their possible interaction mechanism. A cross-sectional study was conducted in the Akonolinga Health District among pupils. Each of them was screened for the presence of peripheral blood parasites stages using Giemsa-stained thick and thin blood films. Socio-demographic information was documented using a questionnaire forms. A total of 416 pupils aged 4-15 years (average: 9.17 ± 0.27) were recruited. The overall prevalence was 4.32% and 37.26% for M. perstans and P. falciparum respectively, and prevalence of co-infection was 1.92%. Mean parasite density was 508.7±310.3 (min: 430 - max: 1300) µF/ml for M. perstans and 5240.38±2037.42 (min: 857 – max: 10400) T/μl for P. falciparum. Risks of single infections (aOR = 0.46, P = 0.0264 for M. perstans and aOR = 0.64, P = 0.0432 for P. falciparum) and co-infection (aOR = 0.10, P = 0.0371) were lower for pupils living in urban area than those living in rural area. Parasitemia of both parasite species were similar in single and co-infection situations (P> 0.05). The interaction between these parasites could involve another mechanism than a competition for blood resources. This study outlined that M. perstans and P. falciparum are co-endemic in the Akonolinga health District. In order to guarantee future success in control and eradication of malaria, a bigger attention should be given to M. perstans or other filarial where it is co-endemic with P. falciparum.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • Faculty of Sciences, University of Douala, Douala, Cameroon

  • Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon

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