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Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats

Received: 26 April 2013     Published: 30 May 2013
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Abstract

Purpose: To investigate the effect of turmeric supplement (T), fermented milk with Probiotic strain Bifidobacterium lactis DN-173 010 (P), a combination of (T+P) on glycemia, lipidemia, and oxidative status in streptozotocin–induced diabetic rats.Materials and methods: Thirty male albino diabetic rats were fed a normal diet and divided to groups (n=6/group) according to the following treatments for 45 days: Turmeric (T) (225mg/kg/d), fermented milk Probiotics (P) (0.5ml/kg/d), Turmeric-Probiotics combination (T+ P) (225mg/kg/d + 0.5ml/kg/d), Oral hypoglycemic agent (OHA) (0.5 ml of glibenclamide; 450 µg/kg/day), and non-treated (DM). Blood glucose and glycayted hemoglobin were determined after diabetes induction and at the end of experiment. Serum insulin, total cholesterol (TC), LDL-C, HDL-C, TG, malondialdehyde (MDA), and total antioxidant capacity (TOAC) biomarker of oxidative stress were determined at the end of experiment. Results: All treatments resulted in a decrease in glucose and HbA1C compared to pretreatment. No difference in insulin concentration was observed. Serum TC was reduced by (T), while LDL-C decreased with (T) and (T+P) treatments. HDL-C was elevated with all treatments compared to control and (OHA) groups. MDA decreased with all treatments. TOAC was elevated with (T) and (T+P) but not with (P) treatment. Conclusion: Administration of Turmeric, Probiotics, and T+P combination were capable in attenuating hyperglycemia, dyslipidemia and oxidative stress initiated by STZ. However, (T) and (T+P) exerted a more potent hypolipidemic, and antioxidative effect compared to (P) alone.

Published in American Journal of Biomedical and Life Sciences (Volume 1, Issue 1)
DOI 10.11648/j.ajbls.20130101.11
Page(s) 1-7
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

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Copyright © The Author(s), 2013. Published by Science Publishing Group

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Keywords

Diabetes, Oxidative Stress, Probiotics, Curcumin, Supplement

References
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    Badkook Maha. (2013). Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats. American Journal of Biomedical and Life Sciences, 1(1), 1-7. https://doi.org/10.11648/j.ajbls.20130101.11

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    Badkook Maha. Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats. Am. J. Biomed. Life Sci. 2013, 1(1), 1-7. doi: 10.11648/j.ajbls.20130101.11

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    AMA Style

    Badkook Maha. Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats. Am J Biomed Life Sci. 2013;1(1):1-7. doi: 10.11648/j.ajbls.20130101.11

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  • @article{10.11648/j.ajbls.20130101.11,
      author = {Badkook Maha},
      title = {Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {1},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.ajbls.20130101.11},
      url = {https://doi.org/10.11648/j.ajbls.20130101.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20130101.11},
      abstract = {Purpose: To investigate the effect of turmeric supplement (T), fermented milk with Probiotic strain Bifidobacterium lactis DN-173 010 (P), a combination of (T+P) on glycemia, lipidemia, and oxidative status in streptozotocin–induced diabetic rats.Materials and methods: Thirty male albino diabetic rats were fed a normal diet and divided to groups (n=6/group) according to the following treatments for 45 days: Turmeric (T) (225mg/kg/d), fermented milk Probiotics (P) (0.5ml/kg/d), Turmeric-Probiotics combination (T+ P) (225mg/kg/d + 0.5ml/kg/d), Oral hypoglycemic agent (OHA) (0.5 ml of glibenclamide; 450 µg/kg/day), and non-treated (DM). Blood glucose and glycayted hemoglobin were determined after diabetes induction and at the end of experiment. Serum insulin, total cholesterol (TC), LDL-C, HDL-C, TG, malondialdehyde (MDA), and total antioxidant capacity (TOAC) biomarker of oxidative stress were determined at the end of experiment. Results: All treatments resulted in a decrease in glucose and HbA1C compared to pretreatment. No difference in insulin concentration was observed. Serum TC was reduced by (T), while LDL-C decreased with (T) and (T+P) treatments. HDL-C was elevated with all treatments compared to control and (OHA) groups. MDA decreased with all treatments. TOAC was elevated with (T) and (T+P) but not with (P) treatment. Conclusion: Administration of Turmeric, Probiotics, and T+P combination were capable in attenuating hyperglycemia, dyslipidemia and oxidative stress initiated by STZ. However, (T) and (T+P) exerted a more potent hypolipidemic, and antioxidative effect compared to (P) alone.},
     year = {2013}
    }
    

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  • TY  - JOUR
    T1  - Antidiabetic Potential of Turmeric with/without Fermented Milk Enriched with Probiotics in Diabetic Rats
    AU  - Badkook Maha
    Y1  - 2013/05/30
    PY  - 2013
    N1  - https://doi.org/10.11648/j.ajbls.20130101.11
    DO  - 10.11648/j.ajbls.20130101.11
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 1
    EP  - 7
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20130101.11
    AB  - Purpose: To investigate the effect of turmeric supplement (T), fermented milk with Probiotic strain Bifidobacterium lactis DN-173 010 (P), a combination of (T+P) on glycemia, lipidemia, and oxidative status in streptozotocin–induced diabetic rats.Materials and methods: Thirty male albino diabetic rats were fed a normal diet and divided to groups (n=6/group) according to the following treatments for 45 days: Turmeric (T) (225mg/kg/d), fermented milk Probiotics (P) (0.5ml/kg/d), Turmeric-Probiotics combination (T+ P) (225mg/kg/d + 0.5ml/kg/d), Oral hypoglycemic agent (OHA) (0.5 ml of glibenclamide; 450 µg/kg/day), and non-treated (DM). Blood glucose and glycayted hemoglobin were determined after diabetes induction and at the end of experiment. Serum insulin, total cholesterol (TC), LDL-C, HDL-C, TG, malondialdehyde (MDA), and total antioxidant capacity (TOAC) biomarker of oxidative stress were determined at the end of experiment. Results: All treatments resulted in a decrease in glucose and HbA1C compared to pretreatment. No difference in insulin concentration was observed. Serum TC was reduced by (T), while LDL-C decreased with (T) and (T+P) treatments. HDL-C was elevated with all treatments compared to control and (OHA) groups. MDA decreased with all treatments. TOAC was elevated with (T) and (T+P) but not with (P) treatment. Conclusion: Administration of Turmeric, Probiotics, and T+P combination were capable in attenuating hyperglycemia, dyslipidemia and oxidative stress initiated by STZ. However, (T) and (T+P) exerted a more potent hypolipidemic, and antioxidative effect compared to (P) alone.
    VL  - 1
    IS  - 1
    ER  - 

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Author Information
  • Department of Food and Nutrition, King AbdulAziz University, Jeddah, Saudi Arabia

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