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Effects of Aqueous Extract of Tetracarpidium conophorum (Mull. Arg.) & Hutch Kernels on Semen Quality and Oxidative Stress Parameters in Male Rats

Received: 9 October 2023     Accepted: 25 October 2023     Published: 22 December 2023
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Abstract

The aim of the present study was to evaluate the effects of the aqueous extract of Tetracarpidium conophorum kernels on semen quality and oxidative stress parameters in male rats. 20 rats were randomly divided into 4 lots of 5 animals each, and lots 1 and 2 were given distilled water and the reference molecule for 28 days, while lots 3 and 4 were treated with the aqueous extract of Tetracarpidium conophorum kernels (250 and 500 mg/kg/po). The results show that administration of aqueous extract of Tetracarpidium conophorum kernels (250 and 500 mg/kg/po) to rats produced significant dose-dependent increases (p < 0.05; p < 0.01) in sperm count and motility compared with the control lot treated with distilled water. On the other hand, pH and sperm vitality showed no significant variation (p > 0.05). Administration of the aqueous extract of Tetracarpidium conophorum kernels at the doses studied resulted in no significant variation (p > 0.05) in MDA and CAT concentrations compared with distilled water. However, there was a significant increase (p < 0.05; p < 0.001) in GSH, and GPX concentrations at the respective doses of 500, 250 and 500 mg/kg of Tetracarpidium conophorum aqueous extract compared to rats given distilled water. Chemical analysis of the aqueous extract of Tetracarpidium conophorum kernels revealed the presence of polyphenols and total flavonoids with anti-free radical and antioxidant effects. These results suggest that the aqueous extract of Tetracarpidium conophorum may have spermatogenic and antioxidant potential.

Published in American Journal of BioScience (Volume 11, Issue 6)
DOI 10.11648/j.ajbio.20231106.15
Page(s) 164-170
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Tetracarpidium conophorum, Oxidative Stress, Semen

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    Herman, A., Landry, M. M., Gallo, M. D. -. B., Stéphane, W. L. B., Moukouma, C., et al. (2023). Effects of Aqueous Extract of Tetracarpidium conophorum (Mull. Arg.) & Hutch Kernels on Semen Quality and Oxidative Stress Parameters in Male Rats. American Journal of BioScience, 11(6), 164-170. https://doi.org/10.11648/j.ajbio.20231106.15

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    ACS Style

    Herman, A.; Landry, M. M.; Gallo, M. D. -. B.; Stéphane, W. L. B.; Moukouma, C., et al. Effects of Aqueous Extract of Tetracarpidium conophorum (Mull. Arg.) & Hutch Kernels on Semen Quality and Oxidative Stress Parameters in Male Rats. Am. J. BioScience 2023, 11(6), 164-170. doi: 10.11648/j.ajbio.20231106.15

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    AMA Style

    Herman A, Landry MM, Gallo MD-B, Stéphane WLB, Moukouma C, et al. Effects of Aqueous Extract of Tetracarpidium conophorum (Mull. Arg.) & Hutch Kernels on Semen Quality and Oxidative Stress Parameters in Male Rats. Am J BioScience. 2023;11(6):164-170. doi: 10.11648/j.ajbio.20231106.15

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  • @article{10.11648/j.ajbio.20231106.15,
      author = {Akassa Herman and Miguel Martial Landry and Mongo Dieu -Merci Bevel Gallo and Wossolo Lingomo Bertrand Stéphane and Constantin Moukouma and Osandze Rachie and Arnaud Wilfrid Etou Ossibi and Ange Antoine Abena},
      title = {Effects of Aqueous Extract of Tetracarpidium conophorum (Mull. Arg.) & Hutch Kernels on Semen Quality and Oxidative Stress Parameters in Male Rats},
      journal = {American Journal of BioScience},
      volume = {11},
      number = {6},
      pages = {164-170},
      doi = {10.11648/j.ajbio.20231106.15},
      url = {https://doi.org/10.11648/j.ajbio.20231106.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20231106.15},
      abstract = {The aim of the present study was to evaluate the effects of the aqueous extract of Tetracarpidium conophorum kernels on semen quality and oxidative stress parameters in male rats. 20 rats were randomly divided into 4 lots of 5 animals each, and lots 1 and 2 were given distilled water and the reference molecule for 28 days, while lots 3 and 4 were treated with the aqueous extract of Tetracarpidium conophorum kernels (250 and 500 mg/kg/po). The results show that administration of aqueous extract of Tetracarpidium conophorum kernels (250 and 500 mg/kg/po) to rats produced significant dose-dependent increases (p  0.05). Administration of the aqueous extract of Tetracarpidium conophorum kernels at the doses studied resulted in no significant variation (p > 0.05) in MDA and CAT concentrations compared with distilled water. However, there was a significant increase (p Tetracarpidium conophorum aqueous extract compared to rats given distilled water. Chemical analysis of the aqueous extract of Tetracarpidium conophorum kernels revealed the presence of polyphenols and total flavonoids with anti-free radical and antioxidant effects. These results suggest that the aqueous extract of Tetracarpidium conophorum may have spermatogenic and antioxidant potential.
    },
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Effects of Aqueous Extract of Tetracarpidium conophorum (Mull. Arg.) & Hutch Kernels on Semen Quality and Oxidative Stress Parameters in Male Rats
    AU  - Akassa Herman
    AU  - Miguel Martial Landry
    AU  - Mongo Dieu -Merci Bevel Gallo
    AU  - Wossolo Lingomo Bertrand Stéphane
    AU  - Constantin Moukouma
    AU  - Osandze Rachie
    AU  - Arnaud Wilfrid Etou Ossibi
    AU  - Ange Antoine Abena
    Y1  - 2023/12/22
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ajbio.20231106.15
    DO  - 10.11648/j.ajbio.20231106.15
    T2  - American Journal of BioScience
    JF  - American Journal of BioScience
    JO  - American Journal of BioScience
    SP  - 164
    EP  - 170
    PB  - Science Publishing Group
    SN  - 2330-0167
    UR  - https://doi.org/10.11648/j.ajbio.20231106.15
    AB  - The aim of the present study was to evaluate the effects of the aqueous extract of Tetracarpidium conophorum kernels on semen quality and oxidative stress parameters in male rats. 20 rats were randomly divided into 4 lots of 5 animals each, and lots 1 and 2 were given distilled water and the reference molecule for 28 days, while lots 3 and 4 were treated with the aqueous extract of Tetracarpidium conophorum kernels (250 and 500 mg/kg/po). The results show that administration of aqueous extract of Tetracarpidium conophorum kernels (250 and 500 mg/kg/po) to rats produced significant dose-dependent increases (p  0.05). Administration of the aqueous extract of Tetracarpidium conophorum kernels at the doses studied resulted in no significant variation (p > 0.05) in MDA and CAT concentrations compared with distilled water. However, there was a significant increase (p Tetracarpidium conophorum aqueous extract compared to rats given distilled water. Chemical analysis of the aqueous extract of Tetracarpidium conophorum kernels revealed the presence of polyphenols and total flavonoids with anti-free radical and antioxidant effects. These results suggest that the aqueous extract of Tetracarpidium conophorum may have spermatogenic and antioxidant potential.
    
    VL  - 11
    IS  - 6
    ER  - 

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Author Information
  • Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of the Congo; Laboratory of Animal Physiology, Faculty of Science and Technology, Marien Ngouabi University, Brazzaville, Republic of the Congo

  • Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of the Congo

  • Departement of Pharmacopeia and Traditional Medicine, Institute of Health Science & Research (IRSSA), Brazzaville, Republic of the Congo; Chemistry Unit of the Plant and Life, Faculty of the Sciences and Techniques, Marien Ngouabi University, Brazzaville, Republic of the Congo

  • Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of the Congo; Laboratory of Animal Physiology, Faculty of Science and Technology, Marien Ngouabi University, Brazzaville, Republic of the Congo

  • Departement of Pharmacopeia and Traditional Medicine, Institute of Health Science & Research (IRSSA), Brazzaville, Republic of the Congo

  • Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of the Congo; Laboratory of Animal Physiology, Faculty of Science and Technology, Marien Ngouabi University, Brazzaville, Republic of the Congo; Departement of Pharmacopeia and Traditional Medicine, Institute of Health Science & Research (IRSSA), Brazzaville, Republic of the Congo

  • Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of the Congo; Laboratory of Animal Physiology, Faculty of Science and Technology, Marien Ngouabi University, Brazzaville, Republic of the Congo

  • Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of the Congo; Faculty of Applied Sciences, Denis Sassou Nguesso University, Kintelé, Republic of the Congo

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