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Novel Uses of Bacteriophages in the Treatment of Human Infections and Antibiotic Resistance

Received: 7 June 2016     Accepted: 18 June 2016     Published: 28 July 2016
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Abstract

As the world is facing a great challenge as a result of antibiotic resistance genes among microbial pathogens to conventional antibiotics, the exploration of the alternatives are highly essential. Scientist now struggle to eliminate the otherwise easy to treat bacterial infection as well as hospital associated infections “nosocomial infections” like methicillin resistance Staphylococcus aureus (MRSA) and vancomycin resistance enterococcus etc. Theoretically, the use of bacteriophages for treatment is simple, though, with the scope of this straightforwardness, a complex pharmacokinetics concerns exist. The basics of drug actions involve two fundamental components: pharmacodynamics and pharmacokinetics. Pharmacodynamics entails the study of the interaction of drugs with their receptors, the transduction systems to which these are linked and the changes they bring about in cells, organs, and the whole organism. While phages distribution from compartment a - b is termed phage pharmacokinetics. To achieve immediate distribution of therapeutic phages into the systemic circulation parenteral route was preferred, and oral delivery was mainly used to treat gastrointestinal infections. Human infections successfully treated using phages include, skin ulcers, wound prophylaxis, burns, gastrointestinal tract infections, respiratory tract infections and otitis etc. PhagoBioderm ® was used in the treatment of skin ulcers, and contains a cocktail of bacteriophages as antibacterial agents in patients resistant to other treatment. In conclusion, phage therapy has a greater diversity of mechanisms of action in comparison with antibiotics; it is very clear that phage therapy has many advantages, to harness this, is a challenge particularly in the face of existing rigorous regulatory practices as well as the reluctance of pharmaceuticals to invest in the field as a result of poor intellectual property and many aspects are not patentable because they are natural entities.

Published in American Journal of BioScience (Volume 4, Issue 3)
DOI 10.11648/j.ajbio.20160403.13
Page(s) 34-40
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Phage Therapy, Antibiotic Resistance, Pharmacodynamics, Pharmacokinetics

References
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[16] Gorski, A. and Weber-Dabrowska, B. (2005). The Potential Role of Endogenous Bacteriophages in Controlling Invading Pathogens. Cell. Mol. Life. Sci 62 (5), pp 511-519.
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Cite This Article
  • APA Style

    Shettima Abubakar, Bello Hauwa Suleiman, Benisheikh Ali. Abbagana, Isa Alhaji Mustafa, Ibn Abbas Musa. (2016). Novel Uses of Bacteriophages in the Treatment of Human Infections and Antibiotic Resistance. American Journal of BioScience, 4(3), 34-40. https://doi.org/10.11648/j.ajbio.20160403.13

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    ACS Style

    Shettima Abubakar; Bello Hauwa Suleiman; Benisheikh Ali. Abbagana; Isa Alhaji Mustafa; Ibn Abbas Musa. Novel Uses of Bacteriophages in the Treatment of Human Infections and Antibiotic Resistance. Am. J. BioScience 2016, 4(3), 34-40. doi: 10.11648/j.ajbio.20160403.13

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    AMA Style

    Shettima Abubakar, Bello Hauwa Suleiman, Benisheikh Ali. Abbagana, Isa Alhaji Mustafa, Ibn Abbas Musa. Novel Uses of Bacteriophages in the Treatment of Human Infections and Antibiotic Resistance. Am J BioScience. 2016;4(3):34-40. doi: 10.11648/j.ajbio.20160403.13

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  • @article{10.11648/j.ajbio.20160403.13,
      author = {Shettima Abubakar and Bello Hauwa Suleiman and Benisheikh Ali. Abbagana and Isa Alhaji Mustafa and Ibn Abbas Musa},
      title = {Novel Uses of Bacteriophages in the Treatment of Human Infections and Antibiotic Resistance},
      journal = {American Journal of BioScience},
      volume = {4},
      number = {3},
      pages = {34-40},
      doi = {10.11648/j.ajbio.20160403.13},
      url = {https://doi.org/10.11648/j.ajbio.20160403.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20160403.13},
      abstract = {As the world is facing a great challenge as a result of antibiotic resistance genes among microbial pathogens to conventional antibiotics, the exploration of the alternatives are highly essential. Scientist now struggle to eliminate the otherwise easy to treat bacterial infection as well as hospital associated infections “nosocomial infections” like methicillin resistance Staphylococcus aureus (MRSA) and vancomycin resistance enterococcus etc. Theoretically, the use of bacteriophages for treatment is simple, though, with the scope of this straightforwardness, a complex pharmacokinetics concerns exist. The basics of drug actions involve two fundamental components: pharmacodynamics and pharmacokinetics. Pharmacodynamics entails the study of the interaction of drugs with their receptors, the transduction systems to which these are linked and the changes they bring about in cells, organs, and the whole organism. While phages distribution from compartment a - b is termed phage pharmacokinetics. To achieve immediate distribution of therapeutic phages into the systemic circulation parenteral route was preferred, and oral delivery was mainly used to treat gastrointestinal infections. Human infections successfully treated using phages include, skin ulcers, wound prophylaxis, burns, gastrointestinal tract infections, respiratory tract infections and otitis etc. PhagoBioderm ® was used in the treatment of skin ulcers, and contains a cocktail of bacteriophages as antibacterial agents in patients resistant to other treatment. In conclusion, phage therapy has a greater diversity of mechanisms of action in comparison with antibiotics; it is very clear that phage therapy has many advantages, to harness this, is a challenge particularly in the face of existing rigorous regulatory practices as well as the reluctance of pharmaceuticals to invest in the field as a result of poor intellectual property and many aspects are not patentable because they are natural entities.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Novel Uses of Bacteriophages in the Treatment of Human Infections and Antibiotic Resistance
    AU  - Shettima Abubakar
    AU  - Bello Hauwa Suleiman
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    T2  - American Journal of BioScience
    JF  - American Journal of BioScience
    JO  - American Journal of BioScience
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    PB  - Science Publishing Group
    SN  - 2330-0167
    UR  - https://doi.org/10.11648/j.ajbio.20160403.13
    AB  - As the world is facing a great challenge as a result of antibiotic resistance genes among microbial pathogens to conventional antibiotics, the exploration of the alternatives are highly essential. Scientist now struggle to eliminate the otherwise easy to treat bacterial infection as well as hospital associated infections “nosocomial infections” like methicillin resistance Staphylococcus aureus (MRSA) and vancomycin resistance enterococcus etc. Theoretically, the use of bacteriophages for treatment is simple, though, with the scope of this straightforwardness, a complex pharmacokinetics concerns exist. The basics of drug actions involve two fundamental components: pharmacodynamics and pharmacokinetics. Pharmacodynamics entails the study of the interaction of drugs with their receptors, the transduction systems to which these are linked and the changes they bring about in cells, organs, and the whole organism. While phages distribution from compartment a - b is termed phage pharmacokinetics. To achieve immediate distribution of therapeutic phages into the systemic circulation parenteral route was preferred, and oral delivery was mainly used to treat gastrointestinal infections. Human infections successfully treated using phages include, skin ulcers, wound prophylaxis, burns, gastrointestinal tract infections, respiratory tract infections and otitis etc. PhagoBioderm ® was used in the treatment of skin ulcers, and contains a cocktail of bacteriophages as antibacterial agents in patients resistant to other treatment. In conclusion, phage therapy has a greater diversity of mechanisms of action in comparison with antibiotics; it is very clear that phage therapy has many advantages, to harness this, is a challenge particularly in the face of existing rigorous regulatory practices as well as the reluctance of pharmaceuticals to invest in the field as a result of poor intellectual property and many aspects are not patentable because they are natural entities.
    VL  - 4
    IS  - 3
    ER  - 

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Author Information
  • Department of Microbiology, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria

  • Department of Microbiology, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria

  • Biotechnology Centre, University of Maiduguri, Maiduguri, Nigeria

  • Department of Microbiology, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria

  • Department of Microbiology, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria

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