International Journal of Clinical Dermatology


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Donovanosis – A Case Report with a Review of Literature

Donovanosis (Granuloma inguinale) is a sexually transmitted bacterial infection affecting the genital, perineal, and perianal regions. It is caused by Klebsiella granulomatis, formerly known as Donovania granulomatis and Calymmatobacterium granulomatis. Without treatment, the infection followed a chronic progressive course with the formation of ulcerations. Upon chronification, severe tissue destruction occurs and malignant transformation is possible. Healing is complete with timely diagnosis and treatment. Donovanosis has not been reported in Bulgaria and herein, we present the first clinical case of this "exotic" for our country sexually transmitted bacterial infection. Our patient was a 38-year-old man of Nigerian origin. The dermatological status is represented by papular and erosive-ulcerative lesions on the skin of the foreskin, the body of the penis, the scrotum and the lower abdomen. Upon Giemsa staining of ulcus material, Donovan corpuscles are found in monocytes. The histopathological examination a lesion demonstrated irregular acanthosis, focal dyskeratosis in the lower epidermal segment, moderate spongiosis, papillary oedema, edema swollen endothelium obstructing the vessels of small and medium caliber, abundant granulomatous tuberculoid infiltrate of epithelioid cells and lymphocytes around the blood vessels in the middle dermis and interstitial. Infectious granulomas are represented by tissue macrophages, epithelioid cells and lymphocytes located around areas of collagen necrosis. Based on the anamnesis, dermatological status and examinations, the diagnosis of donovanosis was made. Epithelialization of the ulks occurred after an extended course of systemic treatment with doxycyclin for 20 days, followed by azax for 7 days. The topical treatment included baths with potassium permanganate and fusidine cream.

Donovanosis, Sexually Transmitted Infection, Genital Ulceration, Diagnosis, Treatment

APA Style

Hristo Mangarov, Valentina Broshtilova, Atanas Batashki, Yoanna Velevska, Petar Vatov, et al. (2023). Donovanosis – A Case Report with a Review of Literature. International Journal of Clinical Dermatology, 6(1), 10-13.

ACS Style

Hristo Mangarov; Valentina Broshtilova; Atanas Batashki; Yoanna Velevska; Petar Vatov, et al. Donovanosis – A Case Report with a Review of Literature. Int. J. Clin. Dermatol. 2023, 6(1), 10-13. doi: 10.11648/j.ijcd.20230601.12

AMA Style

Hristo Mangarov, Valentina Broshtilova, Atanas Batashki, Yoanna Velevska, Petar Vatov, et al. Donovanosis – A Case Report with a Review of Literature. Int J Clin Dermatol. 2023;6(1):10-13. doi: 10.11648/j.ijcd.20230601.12

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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