Clinical Neurology and Neuroscience

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Case Report |

Identifying Cryptococcus Neoformans Neuroinfection Through Neuropsychological Examination

Cryptococcus neoformans is a highly letal and hard-to-be-identified fungal disorder, being its neurocognitive impairment practically non-documented in literature. In this experience-based report, integrated analysis of symptomatology, history of life and neurocognitive assessment regarding a clinical case, provided a quick and easy-access identification of cryptococcus neoformans in a 77-year male (right-handed, 12 years of education). A semi-structured interview explored a variety of risk, favorable and influential factors. Neuropsychological battery included MMSE-2, Digit-Span, STROOP, RAVLT, COWAT, and Clock-Drawing Test. Quantitative and qualitative (verbalizations, test execution procedures and attitude) results have been integrated for his neuropsychological characterization. Main impairment occurred in semantics (mental confusion), processing speed and self-regulatory executive functions. Together, these cognitive functions rely on integrity of cortico-subcortical circuits. His verbal episodic memory was null, but this absent condition might be at least partially attributed to history of alcohol abuse. Motor disturbance slightly affected visuospatial praxia. Recommendations to identify rare neuroinfection through a neuropsychological approach include, beyond quantitative test results of a discriminant neurocognitive battery, proper identification of: an episode-related pattern of symptom evolution; a neurocognitive profile which resembles symptom evolution; and qualitative measures of transitory impairment. Thus, the proposed neuropsychological assessment approach is expected to fasten neuroinfection diagnosis and burn letal possibilities, in simplified, yet fidedign and specialized, clinical contexts.

Cryptococcus, Neuroinfection, Neuropsychological Assessment, Differential Diagnosis

APA Style

Mota, N. (2024). Identifying Cryptococcus Neoformans Neuroinfection Through Neuropsychological Examination. Clinical Neurology and Neuroscience, 8(1), 12-18.

ACS Style

Mota, N. Identifying Cryptococcus Neoformans Neuroinfection Through Neuropsychological Examination. Clin. Neurol. Neurosci. 2024, 8(1), 12-18. doi: 10.11648/j.cnn.20240801.13

AMA Style

Mota N. Identifying Cryptococcus Neoformans Neuroinfection Through Neuropsychological Examination. Clin Neurol Neurosci. 2024;8(1):12-18. doi: 10.11648/j.cnn.20240801.13

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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