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Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets

Recently, chitosan gained a great attention due to its unique biological activities as a natural biodegradable polymer derived from chitin with non-antigenic, non-toxic. It has several positive impacts on animal health including potent antioxidant, antimicrobial activities, and anti-immunogenicity. Therefore, it is a natural, bioactive, mucoadhesive, and biocompatible compound used commonly as a safe additive in animal production. This study was conducted to detect the effects of dietary inclusion of chitosan in high-fat diet (HFD) on growth, hematology, lipid profile, rumen function, oxidative stress, and antioxidant status of Zaraibi goat bucks. Total of 18 sexually mature bucks (38.69±0.57 kg BW) were allocated into 3 groups (n= 6); the control group fed the control diet and treatment groups received HFD (the control diet with 3% fat) and the HFD plus 2.5% chitosan for 8 weeks, respectively. Results showed that HFD increase (P<0.05) final body weight, total weight gain, white blood cells (WBCs), and serum total cholesterol (TC), triglycerides (TG), VLDL, LDL, and malondialdehyde (MDA) with declined free T4 hormone, and HDL with the exhaustion of GSH, CAT and GPx activities beside reducing ruminal total proteins, glucose, ammonia-N, TVFA, total and L-lactate concentrations. Chitosan dietary inclusion to HFD reversed the aforementioned parameters with a notable enhancement of the antioxidant enzyme activities, suppressed the elevated MDA levels, and restored the depleted T4 level. Therefore, chitosan could be safely utilized as a dietary supplement in buck's diets to improve organ functions, lipid profile, antioxidant defense system, scavenge free radicals, and potentiate Buck's reproductive activities.

Chitosan, High Fat Diet, Lipid Metabolism, Antioxidant, Leukocytes, Zaraibi Goat Bucks

APA Style

Doaa Assar, Zizy Elbialy, Rasha Al Wakeel, Naglaa Gomaa, Mahmoud Metwaly El-Maghraby, et al. (2023). Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets. Advances in Applied Physiology, 8(1), 8-16. https://doi.org/10.11648/j.aap.20230801.12

ACS Style

Doaa Assar; Zizy Elbialy; Rasha Al Wakeel; Naglaa Gomaa; Mahmoud Metwaly El-Maghraby, et al. Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets. Adv. Appl. Physiol. 2023, 8(1), 8-16. doi: 10.11648/j.aap.20230801.12

AMA Style

Doaa Assar, Zizy Elbialy, Rasha Al Wakeel, Naglaa Gomaa, Mahmoud Metwaly El-Maghraby, et al. Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets. Adv Appl Physiol. 2023;8(1):8-16. doi: 10.11648/j.aap.20230801.12

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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