Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis:: Science Publishing Group

Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis

Ivana Filipovic¹, Olivera Ostojic², Vesna Vekovic², Sladjana Mihajlovic^1,3, Marco Caminati⁴, Zorica Zivkovic^2,5

¹Hospital for Gynecology and Obstetrics - Neonatology Department, University Hospital dr Dragisa Misovic, Begrade, Serbia

²Children’s Hospital for Lung Diseases and Tb, University Hospital dr Dragisa Misovic, Belgrade, Serbia

³School of Medicine, University of Belgrade, Belgrade, Serbia

⁴Department of Medicine, Allergy Unit and Asthma Center, University of Verona, Verona, Italy

⁵Faculty of Pharmacy, University Business Academy, Novi Sad, Serbia

American Journal of Pediatrics, Volume 9, Issue 4, December 2023

Pages: 186-192

Received: Sep. 05, 2023

Accepted: Sep. 25, 2023

Published: Oct. 08, 2023

DOI: 10.11648/j.ajp.20230904.11

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Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory, pruritic and relapsing skin disease, frequently originated in infants and young children. The objective of our study was to evaluate the clinical efficacy and quality of life in children with AD who were treated with mixture of 3 x 10⁹CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months. Method: This prospective case control study was conducted in the University Hospital “Dr Dragiša Mišović”, Belgrade, Serbia, Hospital for Children’s Hospital for Lung diseases and Tb. The study enrolled 150 patients with AD aged between 3 and 17 years. 75 participants received the treatment: mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months as an add-on to standard AD treatment and 75 of them were treated according to standard protocols for AD. Results: There is a statistically significant difference in SCORAD value before and after the treatment between the groups. Discussion: Our study was the first that assess the efficacy of a mixture of 3 x 109 CFU probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri® form for better resorption and 1200 IJ Vitamin D3 in children with atopic dermatitis. Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.

Keywords

Children, Atopic Dermatitis, Probiotics

To cite this article

Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Sladjana Mihajlovic, Marco Caminati, et al. (2023). Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. American Journal of Pediatrics, 9(4), 186-192. https://doi.org/10.11648/j.ajp.20230904.11

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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