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Interest of the D-dimers Assay in the Medical Care of Thromboembolic Disease: Experience of the Hematology Laboratory of the Military Hospital Avicenne of Marrakech

Received: 22 June 2019     Accepted: 23 July 2019     Published: 10 August 2019
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Abstract

The objective of our study is to show the benefits of D-dimers (DD) dosing in the diagnostic care of thromboembolic disease. A retrospective study conducted over a 2-year period (2016-2017), including all DD dosing requests sent to the hematology laboratory at the Avicenne Military Hospital, excluding patients under 18 years of age. The quantitative assay was performed by an immunoturbidimetric method on STA Compact automaton, (STAGO), with STA®-Liatest® D-Di reagents with respect for the pre-analytical phase. We collected 100 samples over the study’s two year period. The requests mainly came from the emergencies and polyvalent intensive care unit. The clinical picture suggested a deep vein thrombosis in 56% of cases and pulmonary embolism in 44% of cases. The search was positive in 78% of cases. Sensitivity and negative predictive value were 100%. Specificity in the ambulatory population was 66.66% vs 28% in the hospital population and also decreased with age.

Published in American Journal of Biomedical and Life Sciences (Volume 7, Issue 4)
DOI 10.11648/j.ajbls.20190704.12
Page(s) 79-83
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

D-dimeres, Veinous Thromboembolic Disease, Age Factor, Inpatient and Outpatient

References
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[2] Bounameaux H., Slosman D., de Moerloose P., Reber G.,"Diagnostic value of plasma D-dimer in suspected pulmonary embolism", Lancet, 1988 Sep 10; 2 (8611): 628-9.
[3] Raimondi P, Bangard O, de Moerloose P, Reber G, WaldvagelF, Bounameaux H., "D dimer plasma concentration in various clinical conditions: implication of the use of this test in the diagnostic approach of venous thromboembolism", Thromb Res 1993; 69, 125-30.
[4] Stephen J. Wolf, Sigrid A. Hahn, Lauren M. Nentwitch, Ali S. Raja, Scott M. Silvers, Michael D. Brown, "Clinical policy: Critical issues in the evaluation and managment of adult patients presenting to the emergency department with suspected acute veinous thromboembolic disease", Ann. Of Emer. Med., 2018 May; 71 (5).
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[8] Suman W. Rathbun, MD, Thomas L. Whitsett, MD, Sara K. Vesely, PhD, and Gary E. Raskob, "PhD Clinical Utility of D-dimer in Patients With Suspected Pulmonary Embolism and Non diagnostic Lung Scans or Negative CT Findings", Chest 2004 Mar; 125 (3): 851-855.
[9] Schrecengost JE, LeGallo RD, Boyd JC, Moons KG, Gonias SL, Rose CE Jr et al, "Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism", Clin Chem, 2003 Sep; 49 (9): 1483-90.
[10] Macdonald D, Marnnien E, Schwartz K, Dimitrov, "The effects of age on plasma D-Dimer levels", 39th annual meeting of American Society of Hematology, San Diego December 5-9 1997; Abstract n° 3244.
[11] Petitot L, Siméon D, Bombarde A., " À quelles tranches d’âge s’adresse le dosage des D-dimères ?", Immunoanal Biol Spec, 2000; 15: 460–462.
[12] Righini M, Le Gal G, Perrier A, Bounameaux H., " The challenge of diagnosing pulmonary embolism in elderly patients: influence of age on commonly used diagnostic tests and strategies", J Am Geriatr Soc, 2005 Jun; 53 (6): 1039-45.
[13] Jaconelli T, Erragat M, Crane S, et al, "Can an age adjusted D-dimer level be adopted in managing veinous thromboembolism in the emergency departement ? A retrospectiv cohorte studie. Eur J Emer Med. https://doi.org/10.1097/MEJ0000000000000448.
[14] Siméon D, Petitot L, Martelet M, et al., " Apport actuel des D-dimères dans le diagnostic d’exclusion de la maladie thromboembolique veineuse", Immunoanal Biol Spec, 1999; 14: 321–329.
[15] Bounameaux H, de Moerloose P, Perrier A, Miron MJ., "D-dimer testing in suspected venous thromboembolism: an update", QJM, 1997 Jul; 90 (7): 437-42.
[16] Perrier A, Desmarais S, Miron MJ, de Moerloose P, Lepage R, Slosman D, et al., "Non-invasive diagnosis of venous thromboembolism in outpatients", Lancet, 1999 Jan 16; 353 (9148): 190-5.
[17] Van Beek EJ, Schenk BE, Michel BC, van den Ende B, Brandjes DP, van der Heide YT, et al., "The role of plasma D-dimers concentration in the exclusion of pulmonary embolism", Br J Haematol, 1996 Mar; 92 (3): 725-32.
[18] Righini M, Perrier A, De Moerloose P, Bounameaux H., "D-Dimer for venous thromboembolism diagnosis: 20 years later", J Thromb Haemost, 2008 Jul; 6 (7): 1059-71.
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    Maryam Mouamin, Asmaa Allali, Ghali Boufrioua, Jihane Belkhair, Hicham Yahyaoui, et al. (2019). Interest of the D-dimers Assay in the Medical Care of Thromboembolic Disease: Experience of the Hematology Laboratory of the Military Hospital Avicenne of Marrakech. American Journal of Biomedical and Life Sciences, 7(4), 79-83. https://doi.org/10.11648/j.ajbls.20190704.12

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    ACS Style

    Maryam Mouamin; Asmaa Allali; Ghali Boufrioua; Jihane Belkhair; Hicham Yahyaoui, et al. Interest of the D-dimers Assay in the Medical Care of Thromboembolic Disease: Experience of the Hematology Laboratory of the Military Hospital Avicenne of Marrakech. Am. J. Biomed. Life Sci. 2019, 7(4), 79-83. doi: 10.11648/j.ajbls.20190704.12

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    AMA Style

    Maryam Mouamin, Asmaa Allali, Ghali Boufrioua, Jihane Belkhair, Hicham Yahyaoui, et al. Interest of the D-dimers Assay in the Medical Care of Thromboembolic Disease: Experience of the Hematology Laboratory of the Military Hospital Avicenne of Marrakech. Am J Biomed Life Sci. 2019;7(4):79-83. doi: 10.11648/j.ajbls.20190704.12

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  • @article{10.11648/j.ajbls.20190704.12,
      author = {Maryam Mouamin and Asmaa Allali and Ghali Boufrioua and Jihane Belkhair and Hicham Yahyaoui and Mustapha Ait Amer and Mohamed Chakour},
      title = {Interest of the D-dimers Assay in the Medical Care of Thromboembolic Disease: Experience of the Hematology Laboratory of the Military Hospital Avicenne of Marrakech},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {7},
      number = {4},
      pages = {79-83},
      doi = {10.11648/j.ajbls.20190704.12},
      url = {https://doi.org/10.11648/j.ajbls.20190704.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20190704.12},
      abstract = {The objective of our study is to show the benefits of D-dimers (DD) dosing in the diagnostic care of thromboembolic disease. A retrospective study conducted over a 2-year period (2016-2017), including all DD dosing requests sent to the hematology laboratory at the Avicenne Military Hospital, excluding patients under 18 years of age. The quantitative assay was performed by an immunoturbidimetric method on STA Compact automaton, (STAGO), with STA®-Liatest® D-Di reagents with respect for the pre-analytical phase. We collected 100 samples over the study’s two year period. The requests mainly came from the emergencies and polyvalent intensive care unit. The clinical picture suggested a deep vein thrombosis in 56% of cases and pulmonary embolism in 44% of cases. The search was positive in 78% of cases. Sensitivity and negative predictive value were 100%. Specificity in the ambulatory population was 66.66% vs 28% in the hospital population and also decreased with age.},
     year = {2019}
    }
    

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    AU  - Maryam Mouamin
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    AB  - The objective of our study is to show the benefits of D-dimers (DD) dosing in the diagnostic care of thromboembolic disease. A retrospective study conducted over a 2-year period (2016-2017), including all DD dosing requests sent to the hematology laboratory at the Avicenne Military Hospital, excluding patients under 18 years of age. The quantitative assay was performed by an immunoturbidimetric method on STA Compact automaton, (STAGO), with STA®-Liatest® D-Di reagents with respect for the pre-analytical phase. We collected 100 samples over the study’s two year period. The requests mainly came from the emergencies and polyvalent intensive care unit. The clinical picture suggested a deep vein thrombosis in 56% of cases and pulmonary embolism in 44% of cases. The search was positive in 78% of cases. Sensitivity and negative predictive value were 100%. Specificity in the ambulatory population was 66.66% vs 28% in the hospital population and also decreased with age.
    VL  - 7
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Author Information
  • Laboratory Department of Hematology, Avicenna Hospital/Faculty of Medecine and Pharmacy of Marrakech, Marrakech, Morocco

  • Laboratory Department of Hematology, Avicenna Hospital/Faculty of Medecine and Pharmacy of Marrakech, Marrakech, Morocco

  • Laboratory Department of Hematology, Avicenna Hospital/Faculty of Medecine and Pharmacy of Marrakech, Marrakech, Morocco

  • Laboratory Department of Hematology, Avicenna Hospital/Faculty of Medecine and Pharmacy of Marrakech, Marrakech, Morocco

  • Laboratory Department of Hematology, Avicenna Hospital/Faculty of Medecine and Pharmacy of Marrakech, Marrakech, Morocco

  • Laboratory Department of Hematology, Avicenna Hospital/Faculty of Medecine and Pharmacy of Marrakech, Marrakech, Morocco

  • Laboratory Department of Hematology, Avicenna Hospital/Faculty of Medecine and Pharmacy of Marrakech, Marrakech, Morocco

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