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Increased Colorectal Cancer Rate in Turner Syndrome: A Case Control Study
Venkata Subhash Gorrepati,
Djibril M. Ba,
Guodong Liu,
John Levenick,
Thomas McGarrity
Issue:
Volume 9, Issue 5, September 2021
Pages:
219-224
Received:
29 June 2021
Accepted:
12 July 2021
Published:
10 September 2021
DOI:
10.11648/j.ajim.20210905.11
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Abstract: Female sex hormonal supplementation had been shown to be protective against Colorectal cancer (CRC). Turner syndrome (TS) is a rare X lined chromosomal disorder associated with sex hormonal deficiency. Hence, we hypothesized that that females with TS would be at an increased risk of CRC. From the Truven Health Marketscan Commercial Claims and Encounters Database, female patients who had colonoscopy with TS were compared to aged matched to controls. For these patients we obtained demographic variables, risk factors (diabetes, morbid obesity, smoking, use of non-steroidal anti-inflammatory drugs and statins) and endoscopic results (adenoma and cancer detection) from the database. Multivariate logistic regression analysis was performed to compare the cancer detection rates in both groups. Of the 7,77,36,681 patients of age 35 or older in the database 3265 had TS. Of those 546 (17%) patients had a colonoscopy that was reported. These patients were compared to 1059 age matched controls. Prevalence of diabetes (14.3 vs 8.4, P<0.001), and smoking (2.6 vs 0.9, p=0.01) was higher in patients with TS. Cancer detection rate was higher in patients with TS (1.1% vs 0.2%, p=0.01). After adjustment for the above variables, patients with TS have an adjusted odds ratio of 9.5 for CRC at any colonoscopy (95% CI 1.7-52.8, p =0.008). Hence, we concluded that in the studied cohort of TS patients there was a higher colorectal cancer detection rate at any colonoscopy when compared to their age matched female counterparts. TS patients represent a ‘disparity group’ who warrant enhanced CRC screening.
Abstract: Female sex hormonal supplementation had been shown to be protective against Colorectal cancer (CRC). Turner syndrome (TS) is a rare X lined chromosomal disorder associated with sex hormonal deficiency. Hence, we hypothesized that that females with TS would be at an increased risk of CRC. From the Truven Health Marketscan Commercial Claims and Encou...
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COVID-19 Contamination in Hospital Staff: Determinism, Epidemiological Features
Azon-Kouanou Angèle,
Agbodandé Kouessi Anthelme,
Wanvoégbè Armand Finagnon,
Missiho Mahoutin Sèmassa Ghislain,
Sokadjo Yves Morel,
Faladé Adélakoun Ange Géoffroy,
Assogba Houénoudé Mickaël Arnaud,
Mukwege Binji Lisa,
Murhula Katabana Delphin,
Oba Richard,
Dansou Eugénie,
Zannou Djimon Marcel,
Houngbé Fabien
Issue:
Volume 9, Issue 5, September 2021
Pages:
225-229
Received:
26 August 2021
Accepted:
23 September 2021
Published:
30 September 2021
DOI:
10.11648/j.ajim.20210905.12
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Abstract: The first cases of SARS-CoV-2 were diagnosed in BENIN in early March 2020. Measures have been instituted to control its spread, including barrier measures. The objective of this study is to determine the effectiveness of self-application of these measures among hospital staff at CNHU-HKM. Methods: This is a case-control study conducted from July 1, 2020 to January 1, 2021 on the risk factors of COVID-19 contamination. Included were any CNHU-HKM staff who underwent PCR testing for COVID-19 at the CNHU-HKM triage center during the study period. Data were collected using a survey form administered to respondents. Data analysis was performed with R 4.1.0 software. Results: A total of 141 patients were included in the study. The mean age was 35.5 (±11.1) years. The sex ratio (M/F) was 1.87. Fon and Mina ethnic groups were the most represented (74.5%). Workers older than 50 years were more likely to be exposed to COVID-19 (OR=4.83). Nurses in contact with patients (87.2% of the study population) had a higher risk of contamination (OR=3.6), compared to administrative staff. The FFP2 mask was a protective factor (OR=0.35) as well as long-term chemoprophylaxis with chloroquine (OR=0.44). Conclusion: Health care workers are at high risk of contamination by COVID-19. Barrier measures and chloroquine chemoprophylaxis are indeed mandatory in controlling the spread of the pandemic.
Abstract: The first cases of SARS-CoV-2 were diagnosed in BENIN in early March 2020. Measures have been instituted to control its spread, including barrier measures. The objective of this study is to determine the effectiveness of self-application of these measures among hospital staff at CNHU-HKM. Methods: This is a case-control study conducted from July 1,...
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Knowledge, Perception and Attitude of Patients at CNHU-HKM of Cotonou About COVID-19
Azon Kouanou Angèle,
Wanvoégbè Armand Finagnon,
Agbodandé Kouessi Anthelme Mahoutin Sèmassa Ghislain Missiho,
Yves Morel Sokadjo,
Faladé Adélakoun Ange Géoffroy,
Assogba Houénoudé Mickaël Arnaud,
Murhula Katabana Delphin,
Mukwege Bimji Lisa,
Oba Richard,
Eugénie Dansou,
Djimon Marcel Zannou,
Fabien Houngbé
Issue:
Volume 9, Issue 5, September 2021
Pages:
230-235
Received:
26 August 2021
Accepted:
23 September 2021
Published:
30 September 2021
DOI:
10.11648/j.ajim.20210905.13
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Abstract: COVID-19 has been noticed in Benin since March 2020. Various measures have been put in place to curb the epidemic. The objective of the study is to evaluate the knowledge and perception of patients at the CNHU-HKM about COVID-19. This was a cross-sectional study with descriptive and analytical purposes. Data were collected from July 1, 2020 to January 1, 2021. The participants were included in the outpatient clinic of the specialized medical services of the CNHU-HKM. They answered to questions related to their knowledge and perception about COVID-19. Data analysis was done with R 4.1.0 software. A total of 353 respondents were included in the study. The sex ratio was 0.81. The mean age was 48.9±16.8 [10; 92] years. The residence was in urban places for 91.5% of them. The level of education was at least high school in 82.2% of the cases. The agent responsible for COVID-19 and the mode of transmission were not known, respectively, by 31.7% and 89.2% of the participants. Barrier measures were known by 46.2%, while clinical manifestations were known by 89.0%. Only the level of education was associated with knowledge of COVID-19 (p<0.001). Findings revealed that good knowledge of the pandemic was related to the level of education. A readjustment of communication strategies towards less educated groups would be recommended.
Abstract: COVID-19 has been noticed in Benin since March 2020. Various measures have been put in place to curb the epidemic. The objective of the study is to evaluate the knowledge and perception of patients at the CNHU-HKM about COVID-19. This was a cross-sectional study with descriptive and analytical purposes. Data were collected from July 1, 2020 to Janu...
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An Association Between Different Doses of Inhaled Corticosteroids and Glycaemic Status in Patients with Chronic Obstructive Pulmonary Disease
Mohammad Abul Kalam Azad Khan,
Kabirul Hasan Bin Rakib,
Md. Saiful Islam Patwary,
Mohammad Mahmudur Rahman Chowdhury,
Abu Salah Mohammamed Sirajum Munir,
Sohel Ahmed,
Mohammad Ashif Iqbal,
Mohammad Mushahidul Islam,
Md. Abdur Rahim
Issue:
Volume 9, Issue 5, September 2021
Pages:
236-243
Received:
3 October 2020
Accepted:
31 August 2021
Published:
12 October 2021
DOI:
10.11648/j.ajim.20210905.14
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Abstract: Introduction: Inhaled corticosteroids effective medications for the treatment of asthma. Higher doses of inhaled fluticasone (1000 μgm / day) are commonly used in COPD. Such high doses have been associate with significant systemic effects such as pneumonia, glaucoma, cataracts, adrenal suppression and accelerated bone turnover. Aim of the study: The aim of the study was to evaluate the association between different doses of inhaled corticosteroids (Fluticasone Propionate µgm / day) and glycaemic status in Patients with Chronic Obstructive Pulmonary Disease. Material & Methods: This was a cross-sectional analytical study. This study was conducted at the department of Internal Medicine in Bangobandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, during May, 2016-April, 2017. The protocol of this study was approved by IRB and ethical committee. A total of 80 patients with COPD were included in this study, of them clinically diagnosed 40 consecutive COPD patients who were receiving both bronchodilator & inhaled corticosteroids were recruited as case group and clinically diagnosed 40 consecutive COPD patients receiving only bronchodilator without inhaled corticosteroid/systemic steroid were recruited as control, group. Spirometry was done for confirmation and staging of COPD according to GOLD at indoor and OPD patients of Department of Internal Medicine, BSMMU. Results: In case group, the inhaled corticosteroid dose (5000) was counted 02 (5%) and the mean of FPG value was 6.25±1.34, the inhaled corticosteroid dose (1000) was counted 27 (67.5%) and the mean of FPG value was 5.7±1.58, the inhaled corticosteroid dose (2000) was counted 11 (27.5%) and the mean of FPG value was 6.58±2.24. The total FPG mean of the doses was 5.97±1.78. Among case group according to inhaled corticosteroid dose in case group, the inhaled corticosteroid dose (500) was counted 02 (5%) and the mean of 2HABF value was 9.65±3.18, the inhaled corticosteroid dose (1000) was counted 27 (67.5%) and the mean of 2HABF value was 8.71±2.84, the inhaled corticosteroid dose (2000) was counted 11 (27.5%) and the mean of 2HABF value was 9.51±2.9. The total mean of 2HABF value of the doses was 8.98±2.82. In case group, the inhaled corticosteroid dose (500) was counted 02 (5%) and the mean of HbA1C value was 5.85±1.06, the inhaled corticosteroid dose (1000) was counted 27 (67.5%) and the mean of HbA1C value was 6.07±0.7, the inhaled corticosteroid dose (2000) was counted 11 (27.5%) and the mean of HbA1C value was 6.7±0.74. The total mean of HbA1C value of the doses was 6.23±0.77. Conclusion: We had found that 32% of cases and 7.5% of control group were diagnosed as diabetic when fasting plasma glucose taken into account, while in case of 2 hours after breakfast plasma sugar the number were 32.5% and 10% respectively and in case of HbA1c the number were 23.5% and 10% respectively.
Abstract: Introduction: Inhaled corticosteroids effective medications for the treatment of asthma. Higher doses of inhaled fluticasone (1000 μgm / day) are commonly used in COPD. Such high doses have been associate with significant systemic effects such as pneumonia, glaucoma, cataracts, adrenal suppression and accelerated bone turnover. Aim of the study: Th...
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Post COVID-19 Syndrome- A Long Hauling Journey Ahead
Ruqia Asna Rabah,
Farqana Qushnood,
Gurulingappa Basalingappa Doddamani
Issue:
Volume 9, Issue 5, September 2021
Pages:
244-247
Received:
30 September 2021
Accepted:
18 October 2021
Published:
28 October 2021
DOI:
10.11648/j.ajim.20210905.15
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Abstract: Background: COVID -19 pandemic is the most important public health problem of recent time. Tens and thousands of people have suffered with COVID-19 in last one and half year. Most people who have suffered with COVID-19 recover completely within a few weeks but majority of patients continue to have varied symptoms after initial recovery. Objective: To assess the prevalence of Post COVID symptoms, to assess requirement of treatment and to make recommendation for Post COVID syndrome care. Methods: Present cross-sectional study was done among patients who recovered from COVID-19 in GIMS Hospital of Kalaburagi district. Mobile numbers of COVID patients were collected from records. Total 100 randomly selected patients were contacted and information regarding post COVID symptoms in between 6 weeks to 12 weeks after recovery from COVID-19 was collected. Result: 87%patients developed one or more post COVID symptoms. Weakness was reported to be most common problem (55%), followed by body ache (26%) and neuropsychiatric symptoms such as difficulty in concentration and insomnia (22%). Every fifth patient reported that symptoms persisted for more than 1 month. Though most of the respondents classified their symptoms as mild and moderate (52.5% and 37.9% respectively), 47% of the symptomatic patients have to take some treatment for these symptoms. Conclusion: Post COVID symptoms are common but usually less severe. Many of patients required conservative management with medications. Many patients required lot of counselling. Almost one in five patients reported that symptoms persisted for more than one month. The results highlight the need for post COVID care for COVID recovered patients.
Abstract: Background: COVID -19 pandemic is the most important public health problem of recent time. Tens and thousands of people have suffered with COVID-19 in last one and half year. Most people who have suffered with COVID-19 recover completely within a few weeks but majority of patients continue to have varied symptoms after initial recovery. Objective: ...
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